Charge–discharge performances of Li–S battery using NaI–NaBH4–LiI solid electrolyte

Journal of Solid State Electrochemistry - In this study, Li–S batteries were fabricated using 9(15NaI∙NaBH4)∙LiI as the solid electrolyte, and their charge–discharge...     

Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan–Lectin Interaction

Antibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. In this study, we demonstrated that glycan conjugation can modulate antibody dynamics through the glycan–lectin interaction to regulate its potency. The anti-HER2 antibody, an anti-breast-cancer antibody, was conjugated with galactose-containing N-glycan, and its internalization was suppressed by interaction with galectin-3, leading to enhanced complement-dependent cytotoxic (CDC) activity. This glycan–antibody conjugate is proposed as a new approach to modulate antibody activity and may provide an alternative strategy for redeveloping antibody drugs that do not exhibit sufficient activity.     

Synthesis of Quaternary and Tertiary Carbon-Substituted Arenes by Lewis Base Promoted Site-Selective Coupling with Allylic Nucleophiles

A practical method for the preparation of quaternary and tertiary allyl-substituted heteroarenes by site-selective couplings of heteroaryl nitriles and allylic nucleophiles is disclosed. Transformations utilize readily accessible stable reagents, proceed in the presence of a Lewis base activator, and undergo aryl-C(sp³) quaternary and tertiary carbon formation with high γ-selectivity (up to >98 : 2 γ : α).