Synthesis of 4-azepanones and heteroaromatic-fused azepines

Two syntheses of versatile intermediate azepinones 2 and 3 are described. A 6-step intramolecular Dieckmann cyclization and decarboxylation led to the intermediate 3 while an alternate 4-step synthesis of 2 was developed and used for scale-up. The highlight of the second synthesis is the one-step per-bromination/elimination protocol from readily available azepinone 13a to provide a versatile scaffold in vinyl bromide 5, which enables SAR around the aryl moiety. An example of the elaboration of the intermediate 2 toward a heteroaryl azepinone is also described.     

Storage yard operations in container terminals: Literature overview,trends, and research directions

Inbound and outbound containers are temporarily stored in the storage yard at container terminals. A combination of container demand increase and storage yard capacity scarcity create complex operational challenges for storage yard managers. This paper presents an in-depth overview of storage yard operations, including the material handling equipment used, and highlights current industry trends and developments. A classification scheme for storage yard operations is proposed and used to classify scientific journal papers published between 2004 and 2012. The paper also discusses and challenges the current operational paradigms on storage yard operations. Lastly, the paper identifies new avenues for academic research based on current trends and developments in the container terminal industry.     

Transport operations in container terminals: Literature overview,trends, research directions and classification scheme

Internal transport operations connect the seaside, yard side, and landside processes at container terminals. This paper presents an in-depth overview of transport operations and the material handling equipment used, highlights current industry trends and developments, and proposes a new classification scheme for transport operations and scientific journal papers published up to 2012. The paper also discusses and challenges current operational paradigms of transport operations. Lastly, the paper identifies new avenues for academic research based on current trends and developments in the container terminal industry.     

Predicting the Time at Which a Lévy Process Attains Its Ultimate Supremum

We consider the problem of finding a stopping time that minimises the L ¹-distance to θ, the time at which a Lévy process attains its ultimate supremum. This problem was studied in Du Toit and Peskir (Proc. Math. Control Theory Finance, pp. 95–112, 2008) for a Brownian motion with drift and a finite time horizon. We consider a general Lévy process and an infinite time horizon (only compound Poisson processes are excluded. Furthermore due to the infinite horizon the problem is interesting only when the Lévy process drifts to ?∞). Existing results allow us to rewrite the problem as a classic optimal stopping problem, i.e. with an adapted payoff process. We show the following. If θ has infinite mean there exists no stopping time with a finite L ¹-distance to θ, whereas if θ has finite mean it is either optimal to stop immediately or to stop when the process reflected in its supremum exceeds a positive level, depending on whether the median of the law of the ultimate supremum equals zero or is positive. Furthermore, pasting properties are derived. Finally, the result is made more explicit in terms of scale functions in the case when the Lévy process has no positive jumps.     

Multilayer resonances sharpened by grating waveguide resonance

A multilayer planar structure comprising a highly reflective multilayer dielectric mirror and a corrugated waveguide is proposed for use as a narrow passband optical filter. The proposed filter has a much narrower linewidth than a usual Fabry–Perot cavity with two multilayer dielectric mirrors. It is shown that the narrowing of the linewidth is due to the strong spectral dependence of the phase of the wave reflected from the waveguide grating mirror. The shape of the pass band can be made symmetrical by a proper choice of the grating groove profile.     

Aspochalasin H1: A New Cyclic Aspochalasin from Hawaiian Plant-Associated Endophytic Fungus Aspergillus sp. FT1307

Aspergillus is one of the most diverse genera, and it is chemically profound and known to produce many biologically active secondary metabolites. In the present study, a new aspochalasin H1 (1), together with nine known compounds (2–10), were isolated from a Hawaiian plant-associated endophytic fungus Aspergillus sp. FT1307. The structures were elucidated using nuclear magnetic resonance (NMR) (¹H, ¹H-¹H COSY, HSQC, HMBC, ROESY and 1D NOE), high-resolution electrospray ionization mass spectroscopy (HRESIMS), and comparisons with the reported literature. The absolute configuration of the new compound was established by electronic circular dichroism (ECD) in combination with NMR calculations. The new compound contains an epoxide moiety and an adjacent trans-diol, which has not been reported before in the aspochalasin family. The antibacterial screening of the isolated compounds was carried out against pathogenic bacteria (Staphylococcus aureus, Methicillin-resistant S. aureus and Bacillus subtilis). The antiproliferative activity of compounds 1–10 was evaluated against human breast cancer cell lines (MCF-7 and T46D) and ovarian cancer cell lines (A2780).     

An unstructured finite element model for incompressible two-phase flow based on a monolithic conservative level set method

We present a robust numerical method for solving incompressible, immiscible two-phase flows. The method extends both a monolithic phase conservative level set method with embedded redistancing and a semi-implicit high-order projection scheme for variable-density flows. The level set method can be initialized conveniently via a simple phase indicator field instead of a signed distance function (SDF). To process the indicator field into a SDF, we propose a new partial differential equation-based redistancing method. We also improve the monolithic level set scheme to provide more accuracy and robustness in full two-phase flow simulations. Specifically, we perform an extra step to ensure convergence to the signed distance level set function and simplify other aspects of the original scheme. Lastly, we introduce consistent artificial viscosity to stabilize the momentum equations in the context of the projection scheme. This stabilization is algebraic, has no tunable parameters and is suitable for unstructured meshes and arbitrary refinement levels. The overall methodology includes few numerical tuning parameters; however, for the wide range of problems that we solve, we identify only one parameter that strongly affects performance of the computational model and provide a value that provides accurate results across all the benchmarks presented. This methodology results in a robust, accurate, and efficient two-phase flow model, which is mass- and volume-conserving on unstructured meshes and has low user input requirements, making it attractive for real-world applications.