全文获取类型
收费全文 | 1020篇 |
免费 | 43篇 |
国内免费 | 5篇 |
专业分类
化学 | 781篇 |
晶体学 | 9篇 |
力学 | 21篇 |
数学 | 41篇 |
物理学 | 216篇 |
出版年
2023年 | 10篇 |
2022年 | 9篇 |
2021年 | 15篇 |
2020年 | 22篇 |
2019年 | 22篇 |
2018年 | 13篇 |
2017年 | 6篇 |
2016年 | 27篇 |
2015年 | 23篇 |
2014年 | 17篇 |
2013年 | 61篇 |
2012年 | 79篇 |
2011年 | 81篇 |
2010年 | 34篇 |
2009年 | 62篇 |
2008年 | 67篇 |
2007年 | 64篇 |
2006年 | 51篇 |
2005年 | 72篇 |
2004年 | 51篇 |
2003年 | 48篇 |
2002年 | 40篇 |
2001年 | 13篇 |
2000年 | 19篇 |
1999年 | 14篇 |
1998年 | 8篇 |
1997年 | 3篇 |
1996年 | 11篇 |
1995年 | 7篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 9篇 |
1989年 | 2篇 |
1988年 | 6篇 |
1987年 | 10篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 12篇 |
1983年 | 7篇 |
1982年 | 6篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1973年 | 4篇 |
排序方式: 共有1068条查询结果,搜索用时 484 毫秒
221.
T Nohara A Imamura M Yamaguchi KI Hidari T Suzuki T Komori H Ando H Ishida M Kiso 《Molecules (Basel, Switzerland)》2012,17(8):9590-9620
A novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neua2-3 and 2-6 type viruses. 相似文献
222.
T Mizuhara S Oishi H Ohno K Shimura M Matsuoka N Fujii 《Organic & biomolecular chemistry》2012,10(33):6792-6802
3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182) is a virucidal heterocyclic compound active against various viruses, including HCV, HIV, and simian immunodeficiency virus. Using facile synthetic approaches that we developed for the synthesis of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic derivatives, the parallel structural optimizations of the central 1,3-thiazin-2-imine core, the benzene part, and the cyclic amidine part of PD 404182 were investigated. Replacement of the 6-6-6 pyrimido[1,2-c][1,3]benzothiazin-6-imine framework with 5-6-6 or 6-6-5 derivatives led to a significant loss of anti-HIV activity, and introduction of a hydrophobic group at the 9- or 10-positions improved the potency. In addition, we demonstrated that the PD 404182 derivative exerts anti-HIV effects at an early stage of viral infection. 相似文献
223.
Photoluminescence and magnetic circular dichroism of the IrQ(ppy)2-5Cl compound were investigated between 15 and 295 K. These results have been compared with the output files obtained from Density Functional Theory by using the Gaussian 03W software and some additional packages. The experimental results confirm the first triplet state absorption which arises from d to πQ transition. The temperature dependence photoluminescence have shown a small interaction with the polystyrene, used for dispersion of IrQ(ppy)2-5Cl compound. The green and red phosphorescence have the same temperature dependence. The MCD spectra, especially at 15 K, reveals the main transitions involved in the Metal-to-Ligand Charge Transfer processes from the Ir towards the two ligands, phenylpyridine and quinoline, respectively. 相似文献
224.
Okamoto K Sakagami M Feng F Togame H Takemoto H Ichikawa S Matsuda A 《The Journal of organic chemistry》2012,77(3):1367-1377
Full details of the total synthesis of pacidamycin D (4) and its 3'-hydroxy analogue 32 are described. The chemically labile Z-oxyacyl enamide moiety is the most challenging chemical structure found in uridylpeptide natural products. Key elements of our approach to the synthesis of 4 include the efficient and stereocontrolled construction of the Z-oxyvinyl halides 6 and 7 and their copper-catalyzed cross-coupling with the tetrapeptide carboxamide 5, a thermally unstable compound containing a number of potentially reactive functional groups. This synthetic route also allowed us to easily prepare 3'-hydroxy analogue 32. The assemblage by cross-coupling of the Z-oxyvinyl halide 6 and the carboxamide 5 at a late stage of the synthesis provided ready access to a range of uridylpeptide antibiotics and their analogues, despite their inherent labile nature with potential epimerization, simply by altering the tetrapeptide moiety. 相似文献
225.
Gen Tanaka Ikuhiko Nakase Yasunori Fukuda Ryo Masuda Shinya Oishi Kazuya Shimura Yoshimasa Kawaguchi Tomoka Takatani-Nakase Ülo Langel Astrid Gräslund Katsuya Okawa Masao Matsuoka Nobutaka Fujii Yasumaru Hatanaka Shiroh Futaki 《Chemistry & biology》2012,19(11):1437-1446
- Download : Download high-res image (261KB)
- Download : Download full-size image
226.
Three-dimensional numerical simulation of detonations in both a circular tube and a coaxial tube are simulated to reveal characteristics
of single spinning and two-headed detonations. The numerical results show a feature of a single spinning detonation which
was discovered in 1926. Transverse detonations are observed in both tubes, however, the single spinning mode maintains the
complex Mach reflection whereas the two-headed mode develops periodically from the single Mach reflection to the complex one.
The calculated cell aspect ratio for the two-headed mode changes from 1.09 to 1.34 as the radius of axial insert increases
from r
1/R = 0.1 to 0.9. The calculated cell aspect ratio for r
1/R = 0.1 is close to the experimental results without an axial insert. The formation of an unreacted gas pocket behind the detonation
front was not observed in the single spinning mode; however, the two-headed mode has unreacted gas pocket behind the front
near the axial insert.
相似文献
227.
Akane Sato Mizuho Okada Kazuya Saito Michio Sorai 《Acta Crystallographica. Section C, Structural Chemistry》2001,57(5):564-565
In the crystal structure of the title charge‐transfer complex, namely trans‐stilbene–2,2′‐(2,3,5,6‐tetrafluorobenzene‐1,4‐diylidene)propanedinitrile (1/1) (trans‐STB–TCNQF4), C14H12·C12F4N4, the planar STB and TCNQF4 molecules are stacked alternately. The structure is not isostructural with that of STB–TCNQ. No anomaly was found in the displacement parameters of any atoms, while the bond length of the central C=C moiety was shorter than the corresponding bond in ethylene. This suggests that the central C=C moiety of the STB molecule vibrates with a large amplitude, similar to the case in free STB and STB–TCNQ. 相似文献
228.
229.
Sam Benson Antonio Fernandez Nicole D. Barth Fabio deMoliner Mathew H. Horrocks C. Simon Herrington Jose Luis Abad Antonio Delgado Lisa Kelly Ziyuan Chang Yi Feng Miyako Nishiura Yuichiro Hori Kazuya Kikuchi Marc Vendrell 《Angewandte Chemie (International ed. in English)》2019,58(21):6911-6915
The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small‐sized multi‐colored fluorophores for real‐time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin. 相似文献
230.
Prof. Dr. Shoichi Kutsumizu Akane Kawafuchi Prof. Dr. Yasuhisa Yamamura Dr. Taro Udagawa Takashi Otaki Masaki Masuda Prof. Dr. Yohei Miwa Prof. Dr. Kazuya Saito 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(40):10293-10302
A recent intriguing finding that a helical network arrangement forms the bicontinuous cubic phase is attracting great attention for the possibility of new routes to asymmetric synthesis by achiral molecules. However, the design of the molecular structure for the cubic phase is still unrevealed. In this work, a nonsymmetric core molecule with larger naphthalene and smaller benzene moieties at each side of the central linkage and the same disiloxanyldecyloxy terminal at both terminals is shown to be the first example of molecule forming both single-layered and double-layered core assembly modes in the Ia3d phase as a single molecule system. The molecule forms the former mode at high temperatures as a thermodynamically stable phase, similarly to the symmetric naphthalene core system, whereas, on cooling below a temperature (∼350 K), a metastable Ia3d phase forms a double-layered core state down to room temperature, which is common to the benzene core system. As another effect of the nonsymmetric core, the cubic phase is maintained at room temperature for more than 100 days with slight distortion. Infrared spectral studies and quantum chemical calculations suggested the easy transformation between the two core assembly modes. The core nonsymmetry can be a versatile fine-tuning of the core assembly mode and phase stability for the cubic phase molecules. 相似文献