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11.
12.
Treatment of magnesium alkylidene carbenoids, generated from 1-chlorovinyl p-tolyl sulfoxides with isopropylmagnesium chloride at −78 °C in toluene, with 2-lithiothiophenes gave 2-alkenylated thiophenes in good to high yields. The intermediate of this reaction was found to be an alkenylmagnesium, which could be trapped with iodoalkanes and ethyl chloroformate. This procedure offers a novel and efficient one-pot synthesis of thiophenes having a disubstituted or a trisubstituted olefin at the 2-position from thiophenes in good yields. 相似文献
13.
Margiolaki I Margadonna S Prassides K Hansen T Ishii K Suematsu H 《Journal of the American Chemical Society》2002,124(38):11288-11289
The powder neutron diffraction technique has been used for the direct observation of magnetic scattering below a Curie temperature of approximately 14 K in the fullerene-based molecular ferromagnet Eu6C60. Europium is in the divalent state with a magnetic moment of 7.1(3) muB per atom, and the configurational symmetry of the magnetic structure is body-centered cubic. Close contacts between Eu2+ and neighboring C60 units provide the signature of orbital hybridization, which can evidently account for the conducting and magnetic properties of the material. 相似文献
14.
Iida K Todo H Okamoto H Danjo K Leuenberger H 《Chemical & pharmaceutical bulletin》2005,53(4):431-434
An attempt was made to produce carrier particles for dry powder inhalation with lactose carrier particles surface-coated using a Wurster fluidized bed. The lactose carrier particles were coated with lactose aqueous solution containing hydroxypropyl methyl cellulose (HPMC) as a binder using a Wurster coating apparatus. Drug/carrier powder mixtures were prepared consisting of micronized salbutamol sulfate and lactose carriers under various particle surface conditions. These powder mixtures were aerosolized by a Jethaler((R)), and the in vitro deposition properties of salbutamol sulfate were evaluated by a twin impinger. The in vitro inhalation properties of the powder mixture prepared using the coated lactose carrier differed significantly compared with those of the powder mixture prepared using the uncoated lactose carrier, indicating improvements in in vitro inhalation properties of sulbutamol sulfate. In vitro inhalation properties increased with the surface coating time. This surface coating system would thus be valuable for increasing the in vitro inhalation properties of dry powder inhalation with lactose carrier particles. 相似文献
15.
In bacteriorhodopsin (bR), Arg-82bR has been proven to be a very important residue for functional role of this light-driven proton pump. The arginine residue at this position is a super-conserved residue among archaeal rhodopsins. pharaonis phoborhodopsin (ppR; or called as "pharaonis sensory rhodopsin II") has its absorption maximum at 498 nm and acts as a sensor in the membrane of Natronobacterium pharaonis, mediating the negative phototaxis from the light of wavelength shorter than 520 nm. To investigate the role of the arginine residue (Arg-72ppR) of ppR corresponding to Arg-82bR, mutants whose Arg-72ppR was replaced by alanine (R72A), lysine (R72K), glutamine (R72Q) and serine (R72S) were prepared. These mutants were unstable in low concentrations of NaCl and lost their color gradually when the proteins were solubilized with 0.1% n-dodecyl-beta-D-maltoside. The order of instability was R72S > R72A > R72K > R72Q > the wild type. The rates of denaturation were reduced in a solution of high concentrations of monovalent anions. 相似文献
16.
Hiroto Tachikawa Hiroshi Kawabata Kazumi Matsushige 《Journal of organometallic chemistry》2005,690(12):2895-2904
The structures and electronic states of phenyl-capped terthiophene (denoted by P3T) and the ionic species of P3T have been investigated by means of density functional theory (DFT) and direct MO dynamics calculations. P3T is one of the high-performance molecular devices, which has been utilized as a semi-conductor. The calculations indicated that the neutral P3T has a non-planar structure whose the phenyl rings in both ends of thiophene chain are largely deviated from the molecular plane. The cation and anion radicals, dication and dianion were considered as its ionic states. The structure for cation radical of P3T is close to more planar than that of neutral P3T. The structures for anion radical, dication and dianion take a pure planar structure. The first excitation energy of neutral P3T is calculated to be 2.90 eV at the TD-B3LYP/6-31G(d)//B3LYP/6-311+G(d) level, while the P3T cation and anion radicals have lower excitation energies (1.22 and 1.10 eV, respectively). The direct MO dynamics calculation showed that neutral, cation and anion hold near planar structure at 300 K. On the other hand, oligothiophene (n = 5) and its ionic species are strongly deformed from the planar structure, and thiophene rings in both ends of chain rotate rapidly by thermal activation. The mechanism of the electron conductivity in P3T was discussed on the basis of theoretical results. 相似文献
17.
Hiroyuki Ishibashi Hajime Komatsu Kazumi Maruyama Masazumi Ikeda 《Tetrahedron letters》1985,26(47):5791-5794
A Pummerer rearrangement product, 4-chlorophenylthiomethyl trifluoroacetate (6), obtained from 4-chlorophenyl methyl sulfoxide (5) and trifluoroacetic anhydride, reacted with 1-alkenes in trifluoroacetic acid to give the ene products 8, which were readily converted into the terminal 1,3-dienes 10 by oxidation and subsequent pyrolysis. Using this method, 9,11-dodecadien-1-yl acetate (12), a sex pheromone of the red bollworm moth, was synthesized. 相似文献
18.
Reduction followed by cyclization of (Z)-methyl 3-(6-azido-3-chloro-1-methyl-4-oxo-1,4-dihydropyridazin-5-yl)-2-methylacrylate (I) to pyrido[2,3-c]pyridazines by treatment with triethyl phosphite or hydrazine hydrate as the reducing agents is described. Compound I was also reductively cyclized with sodium borohydride. Treatment of I with concentrated sulfuric acid gave 8-chloro-3,6-dimethyl-2,5-dioxo-5,6-dihydro-2H-pyrano[2,3-d] pyridazine (VII) which also could be synthesized by another independent route. A mechanism for the cyclization is proposed. 相似文献
19.
The methyl transfer occurring in the production of methyl N,N-dimethyl-γ-aminobutyrate by pyrolysis of carpronium chloride was examined by means of pyrolysis gas chromatography mass spectrometry with the aid of some deuterated compounds. The mass spectra of methyl N,N-dimethyl-γ-aminobutyrate, produced from deuterated derivatives of carpronium chloride, showed inter alia, characteristic molecular ion peaks which indicated that the methyl of the trimethylammonium group transfers and displaces the methyl of the carbomethoxy group of the tertiary amino compound. The results show that an intermolecular methyl transfer occurs in part on pyrolysis of carpronium chloride, to form methyl N,N-dimethyl-γ-aminobutyrate in which the methyl oxygen is replaced by a methyl from the nitrogen of the original compound. The mechanism presented involves the bimolecular reaction between zwitterionic intermediates formed by ionic O-demethylation of carpronium chloride. 相似文献
20.
Kazumi Ohya Hiroaki Kitaoka Yasuhiko Yotsui Mitsuji Sano 《Journal of mass spectrometry : JMS》1983,18(4):139-146
The mechanism of the pyrolysis reaction of carpronium chloride [(CH3)3N+? (CH2)3? COOCH3CI?] leading to γ-butyrolactone and tetramethylammonium chloride was investigated by means of thermal analysis, pyrolysis gas chromatography mass spectrometry and field desorption mass spectrometry, using deuterium labelling. The results indicated that carpronium chloride pyrolysed to yield equimolar amounts of γ-butyrolactone and tetramethylammonium chloride, methyl transfer occurred between N and O during the pyrolysis process. The mechanism is discussed on the basis of the experimental results, and with the aid of the theoretical results calculated by the CNDO/2 method. The mechanism presented is as follows. γ-Butyrolactone is formed by the intramolecular migration of the π-orbital of C?O to the carbon adjacent to [(CH3)3N]+ via a 5-membered ring transition state, accompanied by a bimolecular reaction between [(CH3)3N]+ and the CH3 of O? CH3, resulting in the formation of tetramethylammonium chloride in an amount equimolar with γ-butyrolactone. 相似文献