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41.
K Konishi H Adachi K Kita S Takamiya R Furushima H Oya I Horikoshi 《Chemical & pharmaceutical bulletin》1989,37(9):2533-2534
The effects of tetragalloylglucose (1,2,3,6-tetra-O-galloyl-beta-D-glucose) on purified complex II (succinate-ubiquinone oxidoreductase) of the mitochondrial electron transport system of Ascaris muscle were studied. Both succinate-ubiquinone-1 (Q1) oxidoreductase, and succinate dehydrogenase measured with 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) in the presence of phenazine methosulfate (PMS) were inhibited by tetragalloylglucose. The inhibitions of both reductase activities of complex II were of competitive type, and the inhibitor constant (Ki) for Ascaris complex II (148 nM) was lower than that for rat liver complex II (1.5 microM). Thus, Ascaris complex II is much more sensitive to this inhibitor than the mammalian counterpart. 相似文献
42.
Yoshizawa M Nagao M Umemoto K Biradha K Fujita M Sakamoto S Yamaguchi K 《Chemical communications (Cambridge, England)》2003,(15):1808-1809
Despite their structural similarity, triangular tetradentate ligands 2b and 2c experience different assembly pathways on complexation with (en)Pd(NO3)2 to give M8L4 tetrahedral (3) and open cone (4) structures, respectively, due to steric restriction by side chains at the corner or on the edge of the ligands. 相似文献
43.
A novel synthetic basic resolving agent, cis-1-aminobenz[f]indan-2-ol (ABI), was rationally designed by introducing effective CH/pi interaction sites to cis-1-aminoindan-2-ol (AI), whose chiral recognition ability has been reported from our laboratory. ABI was applicable to a wide variety of racemic arylalkanoic acids and showed moderate to excellent chiral recognition ability, which was obviously higher than that of AI. The fundamental and important role of CH/pi interactions, such as tunable CH(sp(2))/pi and CH(sp(3))/pi interactions, in the chiral recognition by ABI was revealed by X-ray crystallographic study. 相似文献
44.
Evaluation of the adsorption affinity of proteins to calcium hydroxyapatites by desorption and pre-adsorption methods 总被引:1,自引:0,他引:1
Kazuhiko Kandori Aya Fujiwara Megumi Mukai Akemi Yasukawa Tatsuo Ishikawa 《Colloids and surfaces. B, Biointerfaces》1998,11(6):313-320
The adsorption affinity of bovine serum albumin (BSA) and lysozyme (LSZ) to calcium hydroxyapatite (CaHAP) was evaluated by desorption and two step adsorption methods. These experiments were carried out at 15°C in a 1×10−4 mol dm−3 KCl solution of pH 6.0. BSA molecules were scarcely desorbed, exhibiting an irreversible adsorption of BSA, though LSZ slightly desorbed. This result supports our previous findings that LSZ adsorbs weakly onto phosphate ions exposed on ac or bc faces of CaHAP while BSA adsorbs strongly onto positively charged sites on ac or bc faces of CaHAP. The amount of adsorbed LSZ was markedly increased by the pre-adsorption of BSA, where LSZ was adsorbed onto BSA-covered CaHAP. On the other hand, the amount of adsorbed BSA was not changed by the pre-adsorption of LSZ. In both pre-adsorption systems it was confirmed by an HPLC method that no protein molecule pre-adsorbed was desorbed after the post-adsorption procedure. Therefore, it was interpreted that the enhancement of adsorption of positively charged LSZ is induced by an electrostatic attractive force through pre-adsorption of negatively charged BSA molecules with a high coverage. However, since the coverage of LSZ onto CaHAP is considerably low, no stimulation of BSA adsorption occurred on the LSZ-covered surface. The formation of double protein adsorbed layers consisting of pre- and post-adsorbed proteins was proposed. 相似文献
45.
An L-DNA, the mirror-image isomer of natural DNA, has extraordinary nuclease resistance, and thus the molecules should be promising reagents for many applications, such as antisense technology. However, little is known about the structural and thermodynamic properties of DNAs with this modified nucleotide. In this study, we prepared the L-nucleotide (L-dA) and introduced it into oligodeoxyribonucleotides to assess the ability of the L-nucleotide as a functional molecule for many applications based on the DNA hybridization. Two decamers with an L-dA at the center were synthesized and duplexes with the complementary DNA strand were applied to structural and thermodynamic analyses. The structural study by CD spectra showed that the structures of both modified "L/D-D" duplexes were the typical B-form. This result suggests that the global structure of DNA was not collapsed by the introduction of an L-DNA. Thermodynamic parameters (deltaH degrees, deltaS degrees, and deltaG degrees 37) of the duplex formation, determined by UV melting experiments, indicated that the both duplexes were destabilized at about 2.5 to 3.0 kcal mol(-1) by the introduced L-dA, mainly due to an unfavorable enthalpic effect. In conjunction with information by other researchers, these results suggest that the L-DNA affect on the duplex structure and the stability vary locally; thus, the thermodynamic stability of modified L/D-D duplexes should be predictable by the nearest-neighbor thermodynamic parameters. 相似文献
46.
Nishimura K Suzuki T Momchilova S Miyashita K Katsura E Itabashi Y 《Journal of chromatographic science》2005,43(9):494-499
A simple and highly sensitive method for determining the fatty acid composition of food lipids containing conjugated linoleic acid (CLA) is described. The method is based on the separation of the 9-anthrylmethyl ester derivatives of saturated and unsaturated (conjugated and non-conjugated) fatty acids by reversed-phase high-performance liquid chromatography with fluorescence detection. Just like the other fatty acids, CLA reacts readily with 9-anthryldiazomethane at room temperature to produce 9-anthrylmethyl esters without isomerization and decomposition of the conjugated double bonds. Clear resolution of the individual fatty acids as their 9-anthrylmethyl esters is achieved on a highly efficient octadecylsilylated silica column (150- x 3-mm i.d., 3-microm particle size) using a stepwise gradient elution with methanol-water. The method is standardized with commercially available CLA isomers (cis-9, trans-11 and trans-10, cis-12-octadecadienoic acids, and their cis,cis and trans,trans isomers) and applied for determination of the fatty acid compositions of milk and sdairy products. 相似文献
47.
Hidemasa Okamoto Shoichi Adachi Tadashi Iwai 《Journal of polymer science. Part A, Polymer chemistry》1979,17(5):1267-1277
The γ-ray-induced addition reaction of carbon tetrachloride onto syndiotactic 1,2-polybutadiene film and liquid 1,2-polybutadiene was carried out at room temperature. In the film gelation was pronounced and the rate of addition increased as the crystallinity of the polymer decreased. In the liquid gelation, which makes the polymer insoluble in carbon tetrachloride, did not take place, although a definite crosslinking reaction was noticed. In this case the appearance of the product changed from a viscous liquid to a white powder as the reaction proceeded. Its structure was compared with that of chlorinated 1,2-polybutadiene. The addition of carbon tetrachloride to the vinyl group in liquid 1,2-polybutadiene caused an anti-Markownikoff-type reaction and was accompanied by an unexpectedly large vinyl depletion in the polymer. The total decrease in the vinyl group was found to be much larger than that brought about by the addition of carbon tetrachloride. This discrepancy was attributed to a cyclization and crosslinking reaction ascribed to the vinyl group bound by the main chain. Cyclization and crosslinking were less noticeable in the chlorination than in the carbon tetrachloride. 相似文献
48.
Yoshio Okamoto Kazuhiko Urakawa Heimei Yuki 《Journal of polymer science. Part A, Polymer chemistry》1981,19(6):1385-1395
Asymmetric selective (or stereoelective) polymerization of various racemic methacrylates with cyclohexylmagnesium bromide (c-HexMgBr)-(-)sparteine (1/1.2) catalyst was studied in toluene at ?78°C. The methacrylates of α-ethylbenzyl (EBMA), α-isopropylbenzyl (i-PBMA), α-tert-butylbenzyl (t-BBMA), sec-butyl (s-BuMA), 1-methylallyl (1-MAMA), 2,3-epoxypropyl (2,3-EPMA), 2-phenylpropyl (2-PPMA), and menthyl (MentMA) alcohols were used as racemic monomers. In the polymerization of EBMA and i-PBMA (S) enantiomers were consumed preferentially and the optical purity of initially polymerized i-PBMA was as high as 97%. Optically pure (R) monomers were recovered at about 60% conversion for i-PBMA and 80% for EBMA. In t-BBMA, however, the (R) monomer was consumed preferentially over the (S) isomer. In the polymerization of s-BuMA and 1-MAMA (S) monomers were consumed in excess and the optical purity of the polymers formed in the early stage was about 30%. In 2,3-EPMA and 2-PPMA, which have asymmetric centers at the β position from the ester oxygen, (R) antipodes were more reactive. MentMA did not polymerize at ?78°C. Enantiomer selectivity ratios rS and rR were determined in the polymerization of EBMA, i-PBMA, and 1-MAMA. All polymers except poly(t-BBMA) were highly isotactic, but the tacticity of poly(t-BBMA) could not be estimated. Circular dichroism spectra of optically active polymers of α-substituted benzyl esters were measured. 相似文献
49.
A coulometric method was developed for the determination of microamounts of sulphur in iron and steel. Hydrogen sulphide is quantitatively evolved by reduction with iron(II) in strong phosphoric acid medium and is titrated with electrolytically generated silver ion from a silver anode. Microamounts of sulphide (2.96–224.3 μg) in sodium sulphide standard solutions could be determined with an error of only a few percent. Sulphur in a potassium sulphate standard solution is quantitatively reduced to hydrogen sulphide and could be separated from the solution by heating and determined accurately. Trace amounts of sulphur (7–100 μg g?1) in iron and steels could be determined with a standard deviation of 0.7–2.1 μg g?1. 相似文献
50.
Tobe Y Utsumi N Kawabata K Nagano A Adachi K Araki S Sonoda M Hirose K Naemura K 《Journal of the American Chemical Society》2002,124(19):5350-5364
m-Diethynylbenzene macrocycles (DBMs), buta-1,3-diyne-bridged [4(n)]metacyclophanes, have been synthesized and their self-association behaviors in solution were investigated. Cyclic tetramers, hexamers, and octamers of DBMs having exo-annular octyl, hexadecyl, and 3,6,9-trioxadecyl ester groups were prepared by intermolecular oxidative coupling of dimer units or intramolecular cyclization of the corresponding open-chain oligomers. The aggregation properties were investigated by two methods, the (1)H NMR spectra and the vapor pressure osmometry (VPO). Although some discrepancies were observed between the association constants obtained from the two methods, the qualitative view was consistent with each other. The analysis of self-aggregation by VPO revealed unique aggregation behavior of DBMs in acetone and toluene, which was not elucidated by the NMR method. Namely, the association constants for infinite association are several times larger than the dimerization constant, suggesting that the aggregation is enhanced by the formation of dimers (a nucleation mechanism). In polar solvents, DBMs aggregate more strongly than in chloroform due to the solvophobic interactions between the macrocyclic framework and the solvents. Moreover, DBMs self-associate in aromatic solvents such as toluene and o-xylene more readily than in chloroform. In particular, the hexameric DBM having a large macrocyclic cavity exhibits extremely large association constants in aromatic solvents. By comparing the aggregation properties of DBMs with the corresponding acyclic oligomers, the effect of the macrocyclic structure on the aggregation propensity was clarified. Finally, it turned out that DBMs tend to aggregate more readily than the corresponding phenylacetylene macrocycles, acetylene-bridged [2(n)]metacyclophanes, owing to the withdrawal of the electron density from the aromatic rings by the butadiyne linkages which facilitates pi-pi stacking interactions. 相似文献