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111.
Hiroyuki Usami 《Archive for Rational Mechanics and Analysis》1995,130(3):277-302
Communicated by J. Serrin 相似文献
112.
Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins 总被引:2,自引:0,他引:2
Bi S Song D Kan Y Xu D Tian Y Zhou X Zhang H 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2005,62(1-3):203-212
The interactions of serum albumins such as human serum albumin (HSA) and bovine serum albumin (BSA) with emodin, rhein, aloe-emodin and aloin were assessed employing fluorescence quenching and absorption spectroscopic techniques. The results obtained revealed that there are relatively strong binding affinity for the four anthraquinones with HSA and BSA and the binding constants for the interactions of anthraquinones with HSA or BSA at 20 degrees C were obtained. Anthraquinone-albumin interactions were studied at different temperatures and in the presence of some metal ions. And the competition binding of anthraquinones with serum albumins was also discussed. The Stern-Volmer curves suggested that the quenching occurring in the reactions was the static quenching process. The binding distances and transfer efficiencies for each binding reactions were calculated according to the F?ster theory of non-radiation energy transfer. Using thermodynamic equations, the main action forces of these reactions were also obtained. The reasons of the different binding affinities for different anthraquinone-albumin reactions were probed from the point of view of molecular structures. 相似文献
113.
Hironao Nakayama Masako Nakahara Erina Matsugi Midori Soda Tomoka Hattori Koki Hara Ayuki Usami Chiaki Kusumoto Shigeki Higashiyama Kiyoyuki Kitaichi 《Molecules (Basel, Switzerland)》2021,26(1)
Ferulic Acid (FA) is a highly abundant phenolic phytochemical which is present in plant tissues. FA has biological effects on physiological and pathological processes due to its anti-apoptotic and anti-oxidative properties, however, the detailed mechanism(s) of function is poorly understood. We have identified FA as a molecule that inhibits apoptosis induced by hydrogen peroxide (H2O2) or actinomycin D (ActD) in rat pheochromocytoma, PC12 cell. We also found that FA reduces H2O2-induced reactive oxygen species (ROS) production in PC12 cell, thereby acting as an anti-oxidant. Then, we analyzed FA-mediated signaling responses in rat pheochromocytoma, PC12 cells using antibody arrays for phosphokinase and apoptosis related proteins. This FA signaling pathway in PC12 cells includes inactivation of pro-apoptotic proteins, SMAC/Diablo and Bad. In addition, FA attenuates the cell injury by H2O2 through the inhibition of phosphorylation of the extracellular signal-regulated kinase (ERK). Importantly, we find that FA restores expression levels of brain-derived neurotrophic factor (BDNF), a key neuroprotective effector, in H2O2-treated PC12 cells. As a possible mechanism, FA increases BDNF by regulating microRNA-10b expression following H2O2 stimulation. Taken together, FA has broad biological effects as a neuroprotective modulator to regulate the expression of phosphokinases, apoptosis-related proteins and microRNAs against oxidative stress in PC12 cells. 相似文献
114.
Chang GF Wang CH Lu HC Kan LS Chao I Chen WH Kumar A Lo L dela Rosa MA Hung CH 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(40):11332-11343
Group 12 and silver(I) tetramethyl‐m‐benziporphodimethene (TMBPDM) complexes with phenyl, methylbenzoate, or nitrophenyl groups as meso substituents were synthesized and fully characterized. The dimeric silver(I) complex displays an unusual η2,π coordination from the β‐pyrrolic C?C bond to the silver ion. All of the complexes displayed a close contact between the metal ion and the inner C(22)? H(22) on the m‐phenylene ring. The downfield chemical shifts of H(22) and large coupling constants between CdII and H(22) strongly support the presence of an agostic interaction between the metal ion and inner C(22)–H(22). Crystal structures revealed that the syn form is the predominant conformation for TMBPDM complexes. This is distinctively different from the exclusive anti conformation observed in m‐benziporphyrin and tetraphenyl‐m‐benziporphodimethene (TPBPDM) complexes. Evidently, intramolecular hydrogen‐bonding interactions between axial chloride and methyl groups stabilize syn conformations. Unlike the merely syn conformation observed in the solid‐state structures of TMBPDM complexes that contain an axial chloride, in solution these complexes display highly solvent‐ and temperature‐dependent syn/anti ratio changes. The observation of dynamic 1H NMR spectroscopic scrambling between syn and anti conformations from the titration of chloride ion into the solution of the TMBPDM complex suggests that axial ligand exchange is a likely pathway for the conversion between syn and anti forms. Theoretical calculations revealed that intermolecular hydrogen‐bonding interactions between the axial chloride and CHCl3 stabilizes the anti conformation, which explains the increased ratio for the anti form when dichloromethane or chloroform was used as the solvent. 相似文献
115.
Hong‐Ze Gao Zhong‐Min Su Chun‐Sheng Qin Ri‐Gen Mo Yu‐He Kan 《International journal of quantum chemistry》2004,97(6):992-1001
Bis(2‐methyl‐8‐quinolinolato)aluminum(III) hydroxide complex (AlMq2OH) is used in organic light‐emitting diodes (OLEDs) as an electron transport material and emitting layer. By means of ab initio Hartree–Fock (HF) and density functional theory (DFT) B3LYP methods, the structure of AlMq2OH was optimized. The frontier molecular orbital characteristics and energy levels of AlMq2OH have been analyzed systematically to study the electronic transition mechanism in AlMq2OH. For comparison and calibration, bis(8‐quinolinolato)aluminum(III) hydroxide complex (Alq2OH) has also been examined with these methods using the same basis sets. The lowest singlet excited state (S1) of AlMq2OH has been studied by the singles configuration interaction (CIS) method and time‐dependent DFT (TD‐DFT) using a hybrid functional, B3‐LYP, and the 6‐31G* basis set. The lowest singlet electronic transition (S0 → S1) of AlMq2OH is π → π* electronic transitions and primarily localized on the different quinolate ligands. The emission of AlMq2OH is due to the electron transitions from a phenoxide donor to a pyridyl acceptor from another quinolate ligand including C → C and O → N transference. Two possible electron transfer pathways are presented, one by carbon, oxygen, and nitrogen atoms and the other via metal cation Al3+. The comparison between the CIS‐optimized excited‐state structure with the HF ground‐state structure indicates that the geometric shift is mainly confined to the one quinolate and these changes can be easily understood in terms of the nodal patterns of the highest occupied and lowest unoccupied molecular orbitals. On the basis of the CIS‐optimized structure of the excited state, TD‐B3‐LYP calculations predict an emission wavelength of 499.78 nm. An absorption wavelength at 380.79 nm on the optimized structure of B3LYP/6‐31G* was predicted. They are comparable to AlMq2OH 485 and 390 nm observed experimentally for photoluminescence and UV‐vis absorption spectra of AlMq2OH solid thin film on quartz, respectively. Lending theoretical corroboration to recent experimental observations and supposition, the reasons for the blue‐shift of AlMq2OH were revealed. © 2003 Wiley Periodicals, Inc. Int J Quantum Chem, 2004 相似文献
116.
Chi C. Hua Fu Y. Hsu Mu G. Chang Chun J. Kan 《Macromolecular theory and simulations》2004,13(6):550-559
Summary: A nonisothermal plug‐flow reactor for ethylene polymerization is reexamined so as to illustrate the principle and effect of a refined, semi‐microscopic modeling. The novel feature of the current simulation is the application of a Monte Carlo scheme to exactly solve the free‐radical polymerization involved, whereas a reptation‐based molecular theory is introduced in a self‐consistent manner to simulate more accurately the reactant fluid viscosity during polymerization. The simulation is shown to capture some in‐depth consequences of reaction‐transport coupling that cannot be revealed by a traditional, macroscopic type of modeling. The principle of a future extension for dealing with more complex flow reactors is briefly discussed.
117.
Jing-Kun Fang De-Lie An Kan Wakamatsu Tetsuo Iwanaga Daisuke Matsuo Junzo Otera 《Tetrahedron letters》2010,51(6):917-6811
A series of diphenylamino-substituted phenylene-(poly)ethynylenes were successfully synthesized by a combination of Sonogashira coupling and double elimination protocol of β-substituted sulfones. When UV-light was irradiated, the amino-substituted phenylene-(poly)ethynylene emitted strong luminescence. The emission underwent a large bathochromic shift in polar solvent because of stabilization of their charge-separated excited states. Analyses of fluorescence life times of aminoacetylenes revealed that radiationless process was suppressed in the polar solvent CH2Cl2, resulting in high quantum yields. 相似文献
118.
辣根过氧化物酶在亲水性离子液体中的活性与稳定性研究 总被引:1,自引:2,他引:1
基于辣根过氧化物酶对过氧化氢氧化愈创木酚这个显色反应的催化作用,研究了辣根过氧化物酶在七种亲水性离子液体[C2mim][BF4]、[C4mim][BF4]、[C6mim][BF4]、[C4mim]HSO4、[C4mim]Cl、[C4mim]NO3、[C4mim][CF3CO2]中的活性与稳定性变化.结果表明辣根过氧化物酶在不同离子液体中均有不同程度的失活,辣根过氧化物酶活性随离子液体极性增强而降低.辣根过氧化物酶在含[C4mim]Cl离子液体的介质中,随着温度升高,[C4mim]Cl对辣根过氧化物酶的失活过程起加速作用,离子液体浓度越高,酶的热稳定性越差.紫外-可见光谱研究表明,在含[Cnmim][BF4]、[C4mim]HSO4、[C4mim]Cl、[C4mim]NO3的介质中,辣根过氧化物酶血红素中心最大吸收峰没有发生变化,但吸收值增强,证明离子液体使酶的血红素基团暴露于介质中而增强了吸收;而在含[C4mim][CF3CO2]的介质中,辣根过氧化物酶血红素基团最大吸收峰区发生蓝移,证明有部分血红素基团被离子液体破坏而脱落. 相似文献
119.
Jinfeng Yang Koichi Kan Nobuyasu Naruse Yoichi Yoshida Katsumi Tanimura Junji Urakawa 《Radiation Physics and Chemistry》2009,78(12):1106-1111
A near-relativistic 100-fs MeV electron beam is developed by using a photocathode rf gun for revealing the hidden ultrafast dynamics of intricate molecular and atomic processes in materials through experimentation of ultrafast time-resolved electron diffraction (UED). The transverse and longitudinal dynamics of femtosecond electron beam in the rf gun were studied theoretically by particle simulation. The growths of the emittance, bunch length and energy spread due to the rf and space charge effects were investigated by changing the laser parameters, field gradient and electron charge. The theoretical studies indicate that a 100-fs MeV electron beam with the transverse emittance of 0.1 mm mrad and the relative energy spread of 10−3–10−4 at bunch charge of 0.1–2 pC (106–107 electrons per pulse) is achievable for UED, in which the intensity is three orders of magnitude higher than that produced by the conventional dc or pulsed guns. 相似文献
120.
The detailed isomerization and dissociation reaction potential energy profile of the CH3PO2 system was established at the UCCSD(T)/6‐311++G(3df,2p)//UB3LYP/6‐311++G(d,p) level of theory. Seventy minimum isomers were located and connected by 93 optimized interconversion transition states. Furthermore, 32 isomers with high kinetic stability were predicted to be possible candidates for further experimental detection. The bonding nature of the suggested stable isomers was analyzed while their molecular properties including heats of formation, adiabatic ionization potentials, and adiabatic electronic affinities were calculated at the G2, G2(MP2), G3, and CBS‐Q levels. Based on the isomerization and dissociation potential energy surface, possible unimolecular decomposition mechanisms and pathways of the low‐lying molecules CH3P(?O)2, CH3O? P?O, and CH2?P(?O)OH were discussed. Furthermore, the transition state theory rate constants of the primary unimolecular dissociation channels were also calculated. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009 相似文献