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971.
Lim JW Mathias RA Kapp EA Layton MJ Faux MC Burgess AW Ji H Simpson RJ 《Electrophoresis》2012,33(12):1873-1880
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene are common in both inherited and sporadic forms of colorectal cancer (CRC), and are associated with dysregulated Wnt signaling. Colon carcinoma SW480 cells restored with stable expression of wild-type APC (SW480APC cells) exhibit attenuated Wnt signaling, and reduced tumorigenicity, including increased cell adhesion. We performed a comparative proteomic analysis of exosomes isolated from SW480 and SW480APC cells to examine the effects of restored APC on exosome protein expression. A salient finding of our study was the unique expression of the Wnt antagonist Dickkopf-related protein 4 (DKK4) in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by semiquantitative RT-PCR, immunoblotting, and immunogold electron microscopy. Analysis of the DKK4 gene promoter by methylation-specific PCR revealed reduced methylation in SW480APC cells, while RT-PCR demonstrated the downregulation of DNMT-3a, compared to the parental cell line. Our discovery of exosome-mediated secretion of DKK4 opens up the possibility that exosomal DKK4 may be a mechanism used by epithelial colon cells to regulate Wnt signaling which is lost during CRC progression. 相似文献
972.
973.
Chuah K Lai LM Goon IY Parker SG Amal R Justin Gooding J 《Chemical communications (Cambridge, England)》2012,48(29):3503-3505
Herein, we demonstrate the use of modified gold-coated magnetic nanoparticles as 'dispersible electrodes' which act as selective capture vehicles for electrochemical detection of prostate-specific antigen (PSA). A key advantage of this system is the ability to quantify non-electrochemical active analytes such as proteins with unprecedented detection limits and fast response times. 相似文献
974.
Harpham MR Nguyen SC Hou Z Grossman JC Harris CB Mara MW Stickrath AB Kanai Y Kolpak AM Lee D Liu DJ Lomont JP Moth-Poulsen K Vinokurov N Chen LX Vollhardt KP 《Angewandte Chemie (International ed. in English)》2012,51(31):7692-7696
Caught in the light: The fulvalene diruthenium complex shown on the left side of the picture captures sun light, causing initial Ru-Ru bond rupture to furnish a long-lived triplet biradical of syn?configuration. This species requires thermal activation to reach a crossing point (middle) into the singlet manifold on route to its thermal storage isomer on the right through the anti?biradical. 相似文献
975.
Restricted isometries for partial random circulant matrices 总被引:1,自引:0,他引:1
976.
General and scalable amide bond formation with epimerization-prone substrates using T3P and pyridine
The mild combination of T3P (n-propanephosphonic acid anhydride) and pyridine has been developed for low-epimerization amide bond formation and implemented for the synthesis of a key intermediate to a glucokinase activator. This robust method is general for the coupling of various racemization-prone acid substrates and amines, including relatively non-nucleophilic anilines, and provides amides in high yields with very low epimerization. With easy reaction setup and product isolation, this protocol offers several practical and experimental benefits. 相似文献
977.
Ciampi S James M Darwish N Luais E Guan B Harper JB Gooding JJ 《Physical chemistry chemical physics : PCCP》2011,13(34):15624-15632
A novel method to prepare redox monolayers on silicon electrodes has been developed that employs Cu(I)-catalyzed oxidative acetylenic coupling reactions for molecular electronic type applications. As the first case study, ethynylferrocene was covalently immobilized onto an acetylene-terminated monolayer on a Si(100) surface to give a 1,3-diyne (C≡C-C≡C-) linked redox assembly. The derivatization process requires no protection/de-protection steps, nor activation procedures. The effect of the conjugated diyne linkage on the rate of electron transfer between tethered ferrocenyl units and the silicon electrode is benchmarked against well-established "click" products (i.e. 1,2,3-triazole linkage). The surfaces, after each step, are characterized thoroughly using X-ray reflectivity (XRR), X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The coupling chemistry provides a useful strategy for functionalizing silicon surfaces and contributes to an expanding repertoire of wet chemistry routes for the functionalization of solid substrates. 相似文献
978.
Bartlett NC Jankunas J Goswami T Zare RN Bouakline F Althorpe SC 《Physical chemistry chemical physics : PCCP》2011,13(18):8175-8179
We have measured differential cross sections (DCSs) for the reaction H + D(2) → HD(v' = 2,j' = 0,3,6,9) + D at center-of-mass collision energies E(coll) of 1.25, 1.61, and 1.97 eV using the photoloc technique. The DCSs show a strong dependence on the product rotational quantum number. For the HD(v' = 2,j' = 0) product, the DCS is bimodal but becomes oscillatory as the collision energy is increased. For the other product states, they are dominated by a single peak, which shifts from back to sideward scattering as j' increases, and they are in general less sensitive to changes in the collision energy. The experimental results are compared to quantum mechanical calculations and show good, but not fully quantitative agreement. 相似文献
979.
Zhou Q He Y Abell J Zhang Z Zhao Y 《Chemical communications (Cambridge, England)》2011,47(15):4466-4468
Helical silver nanorod arrays with different arm numbers are designed by oblique angle deposition and their surface-enhanced Raman scattering properties are characterized. Assuming that the hot spots are located at the bends between the arms, and considering the optical absorbance of different layers, the SERS behavior can be predicted qualitatively. 相似文献
980.
We consider an n-person economy in which efficiency is independent of distribution but the cardinal properties of the agents’ utility functions may preclude transferable utility (a property we call “Almost TU”). Holding the disagreement point fixed, we show that Almost TU is a necessary and sufficient condition for all agents to either benefit jointly or suffer jointly with any change in production possibilities under well-behaved generalized utilitarian bargaining solutions (of which the Nash bargaining and the utilitarian solutions are special cases). We apply the result to policy analysis and to incentive compatibility. 相似文献