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Tyrosine nitration of human ERK1 introduces an intra-hydrogen bond by molecular dynamics simulations
Xu Wu Zhang Yuanya Achi Oliver Y. Knierim Kathleen D. Hanks Justin G. Wang Yingchun 《Structural chemistry》2019,30(4):1459-1470
Structural Chemistry - ERK1 is an important kinase in Ras–Raf–MEK signaling. We have recently demonstrated by mass spectrometry that Tyr210 of ERK1 can be nitrated, and the nitration... 相似文献
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To date almost all verifications of Oliver’s p-group conjecture have proceeded by verifying a stronger conjecture about weakly closed quadratic subgroups. We construct a group of order 349 which refutes the weakly closed conjecture but satisfies Oliver’s conjecture. 相似文献
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Dr. Anthony J. Kim Dr. Nicholas J. Boylan Dr. Jung Soo Suk Minyoung Hwangbo Tao Yu Benjamin S. Schuster Dr. Liudimila Cebotaru Dr. Wojciech G. Lesniak Joon Seok Oh Pichet Adstamongkonkul Ashley Y. Choi Prof. Dr. Rangaramanujam M. Kannan Prof. Dr. Justin Hanes 《Angewandte Chemie (International ed. in English)》2013,52(14):3985-3988
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Lisa M. Jones Hao Zhang Weidong Cui Sandeep Kumar Justin B. Sperry James A. Carroll Michael L. Gross 《Journal of the American Society for Mass Spectrometry》2013,24(6):835-845
As therapeutic monoclonal antibodies (mAbs) become a major focus in biotechnology and a source of the next-generation drugs, new analytical methods or combination methods are needed for monitoring changes in higher order structure and effects of post-translational modifications. The complexity of these molecules and their vulnerability to structural change provide a serious challenge. We describe here the use of complementary mass spectrometry methods that not only characterize mutant mAbs but also may provide a general framework for characterizing higher order structure of other protein therapeutics and biosimilars. To frame the challenge, we selected members of the IgG2 subclass that have distinct disulfide isomeric structures as a model to evaluate an overall approach that uses ion mobility, top-down MS sequencing, and protein footprinting in the form of fast photochemical oxidation of proteins (FPOP). These three methods are rapid, sensitive, respond to subtle changes in conformation of Cys?→?Ser mutants of an IgG2, each representing a single disulfide isoform, and may be used in series to probe higher order structure. The outcome suggests that this approach of using various methods in combination can assist the development and quality control of protein therapeutics. 相似文献
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Justin J. Maresh Sonia E. Chavez Matthew J. Asciutto Nathan D. Brown Alexander A. Delgado Youya Gao 《高分子科学杂志,A辑:纯化学与应用化学》2013,50(9):683-688
Electrophilic trisubstituted ethylenes, phenoxy ring-substituted methyl 2-cyano-3-phenyl-2-propenoates, RPhCH=C(CN)CO2CH3, where R is 4-(4-BrC6H5O), 2-(4-ClC6H5O), 3-(4-ClC6H5O), 4-(3-ClC6H5O), 4-(4-ClC6H5O), 4-(4-FC6H5O), 2-(3-CH3OC6H5O), 2-(4-CH3OC6H5O), 3-(4-CH3OC6H5O), 4-(4-CH3OC6H5O), 3-(4-CH3C6H5O) were prepared and copolymerized with styrene. The monomers were synthesized by the piperidine catalyzed Knoevenagel condensation of phenoxy ring-substituted benzaldehydes and methyl cyanoacetate, and characterized by CHN analysis, IR, 1H and 13C-NMR. All the ethylenes were copolymerized with styrene (M1) in solution with radical initiation (ABCN) at 70°C. The compositions of the copolymers were calculated from nitrogen analysis and the structures were analyzed by IR, 1H and 13C-NMR. The order of relative reactivity (1/r1) for the monomers is 4-(4-CH3OC6H5O) (6.07) > 3-(4-ClC6H5O) (3.38) > 3-(4-CH3OC6H5O) (2.78) > 4-(3-ClC6H5O) (2.77) > 2-(4-ClC6H5O) (2.29) > 3-(4-CH3C6H5O) (1.98) > 4-(4-FC6H5O) (1.92) > 4-(4-ClC6H5O) (1.89) > 2-(3-CH3OC6H5O) (1.39) > 2-(4-CH3OC6H5O) (0.90) > 4-(4-BrC6H5O) (0.77). Relatively high Tg of the copolymers in comparison with that of polystyrene indicates a decrease in chain mobility of the copolymer due to the high dipolar character of the trisubstituted ethylene monomer unit. Decomposition of the copolymers in nitrogen occurred in two steps, first in the 200-500°C range with residue (2.5-8.0% wt), which then decomposed in the 500-800°C range. 相似文献