Multilayer Film Fabrication Using Flow Injection Coupled with Electrochemical Deposition

A simple method is proposed for the electrodeposition of multilayers using a modified closed flow injection system. The apparatus incorporates flowing streams of electrolyte through a closed atmosphere flow cell for deposition of multilayers. Computer and software control is used to alternate the flow of electrolyte and control the alternating current or potential of the electrochemical cell. Electrodeposition of metallic multilayers of nickel/iron, iron/copper, cobalt/copper, and nickel/copper were used to test the instrument design. X‐ray diffraction was used to verify the composition and orientation of the films and scanning electron microscopy was used to examine the morphology of the deposited films. Advantages are discussed for using this type of instrumental setup for multilayer fabrication.     

Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator

Background  

Urokinase-type plasminogen activator (uPA) plays a major role in extracellular proteolytic events associated with tumor cell growth, migration and angiogenesis. Consequently, uPA is an attractive target for the development of small molecule active site inhibitors. Most of the recent drug development programs aimed at nonpeptidic inhibitors targeted at uPA have focused on arginino mimetics containing amidine or guanidine functional groups attached to aromatic or heterocyclic scaffolds. There is a general problem of limited bioavailability of these charged inhibitors. In the present study, uPA inhibitors were designed on an isocoumarin scaffold containing uncharged substituents.     

Spectral functions at small energies and the electrical conductivity in hot quenched lattice QCD

In lattice QCD, the maximum entropy method can be used to reconstruct spectral functions from Euclidean correlators obtained in numerical simulations. We show that at finite temperature the most commonly used algorithm, employing Bryan's method, is inherently unstable at small energies and gives a modification that avoids this. We demonstrate this approach using the vector current-current correlator obtained in quenched QCD at finite temperature. Our first results indicate a small electrical conductivity above the deconfinement transition.