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941.
Kaixia Zhang Jun Zhang Shenghua Wei Wenguang Jing Yuesheng Wang An Liu 《Journal of separation science》2013,36(15):2407-2413
Polygonum capitatum, a traditional Miao medicinal plant, has significant effects on the treatment of urinary system infections and pyelonephritis. However, no study about the comprehensive quality evaluation of P. capitatum has been reported. In this contribution, a rapid and validated method based on HPLC coupled with triple quadrupole MS was established for the simultaneous determination of six active flavonoids, six phenolic acids, and a lignan in extracts of P. capitatum. These compounds were separated within 10 min on a C18 analytical column with gradient elution. All analyses were performed on an Agilent XDB C18 column (2.1 × 100 mm, 3.5 μm) with a linear gradient elution of acetonitrile/water. The proposed method was applied to analyze 15 batches of samples with acceptable linearity (r2, 0.9923–0.9992), precisions (RSD, 1.0–3.0%), repeatability (RSD, 2.0–3.2%), stability (RSD, 2.2–3.2%), and recovery (RSD, 2.1–3.6%) of the 13 compounds. These results demonstrated that this presented method was effective and reliable for the comprehensive quality evaluation of P. capitatum. Moreover, our study can provide chemical evidence to reveal the material basis of its therapeutic effects. 相似文献
942.
Qiuyun Wang Yajin Xiong Baozhu Lu Jun Fan Sheng Zhang Shengrun Zheng Weiguang Zhang 《Journal of separation science》2013,36(8):1343-1348
N‐(2,4‐dinitrophenyl)‐proline and N‐(2,4‐dinitrophenyl)‐serine were enantiomerically resolved on the BSA chiral stationary phase by HPLC in reversed‐phase mode. Effects of chromatographic conditions on enantioseparation and elution order have been investigated in detail. For these two samples, reversal of enantiomer elution order was observed by changing buffer pH, the content of acetonitrile, or alcohol modifiers in mobile phase, which is firstly reported in the BSA chiral stationary phase studies. More interestingly, combined effect between buffer pH and the content of acetonitrile was also observed. In addition, coelution range of enantiomers varied along with the content of acetonitrile in mobile phase. 相似文献
943.
Water-soluble gelatin–PbS bionanocomposites(BNCs)were synthesized via a facile one-pot chemical reaction method at pH7.40.The samples were characterized by transmission electron microscopy(TEM),X-ray diffraction(XRD),UV-vis absorption spectra(UV-vis),Fourier transform infrared spectra(FT-IR)and circular dichroism(CD).FT-IR data were used to envisage the binding of PbS particles with oxygen atoms of carbonyl groups of gelatin molecule.The possible integration mechanism between gelatin and PbS was discussed in detail.The effect of Pb2+and PbS on the conformations of gelatin has also been analyzed by means of UV-vis,CD and FT-IR spectra,resulting in less-helix content and more open structures(-sheet,β-turn,or expanded).A new formula to calculate the association constant was proposed according to the relationship between the absorbance of gelatin–PbS BNCs and the free concentration of PbS,and apparent association constants K(298/303/308 K:3.11/2.00/1.60×106mol/L)at three different temperatures were calculated based on this formula.Thermodynamic parameters such asΔGθ,ΔHθ andΔSθ were also determined.The results of the thermodynamic investigations indicated that the reaction was spontaneous(ΔGθ<0),and enthalpy-driven(ΔHθ<0). 相似文献
944.
ZHU ZhenFeng ZHAO XinYuan QIN Wei CHEN GuangDi QIAN Jun XU ZhengPing 《中国科学:化学(英文版)》2013,56(9):1247-1252
2,3-Bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)phenyl) fumaronitrile (TPE-TPA-FN or TTF), which possesses aggregation-induced emission (AIE) characteristic, is doped in organically modified silica (ORMOSIL) nanoparticles. By increasing the weight ratio of TTF to the precursor of silica nanoparticles (the quantities of the precursors were kept the same), the fluorescence intensity of nanoparticles increased correspondingly, due to the formation of larger AIE dots in the cores of ORMOSIL nanoparticles. The fluorescent and biocompatible nanoprobes were then utilized for in vitro imaging of HeLa cells. Two-photon fluorescence microscopy clearly illustrated that the nanoparticles have the capacity of nucleus permeability, as well as cytoplasm staining towards tumor cells. Our experimental results may offer a promising method for fast and bright fluorescence imaging, as well as bio-molecule/drug delivery to cell nucleus. 相似文献
945.
XU Jun GU Qiong LIU HaiBo ZHOU JiaJu BU XianZhang HUANG ZhiShu LU Gui LI Ding WEI DongQing WANG Ling GU LianQuan 《中国科学:化学(英文版)》2013,56(1):71-85
Chemomics is an interdisciplinary study using approaches from chemoinformatics,bioinformatics,synthetic chemistry,and other related disciplines.Biological systems make natural products from endogenous small molecules (natural product building blocks) through a sequence of enzyme catalytic reactions.For each reaction,the natural product building blocks may contribute a group of atoms to the target natural product.We describe this group of atoms as a chemoyl.A chemome is the complete set of chemoyls in an organism.Chemomics studies chemomes and the principles of natural product syntheses and evolutions.Driven by survival and reproductive demands,biological systems have developed effective protocols to synthesize natural products in order to respond to environmental changes;this results in biological and chemical diversity.In recent years,it has been realized that one of the bottlenecks in drug discovery is the lack of chemical resources for drug screening.Chemomics may solve this problem by revealing the rules governing the creation of chemical diversity in biological systems,and by developing biomimetic synthesis approaches to make quasi natural product libraries for drug screening.This treatise introduces chemomics and outlines its contents and potential applications in the fields of drug innovation. 相似文献
946.
In life sciences,molecules are categorized into biological macromolecules(protein,DNA,RNA etc.)and small molecules(neurotransmitters,vitamins,drugs,natural products,water etc.).The main methodology of chemistry for life sciences is using chemical techniques and tools to explore and manipulate the functions of biological macromolecules.This methodology can be traced back to W hler’s synthesis of urea from"inorganic"compounds in 1828.Today,we realize that chemistry can advance a molecular understanding of biology,and the harnessing of biology can advance chemical knowledge as well[1–4].Chemicals are widely used as probes to investigate biological functions[5–7]. 相似文献
947.
Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands
Human intestinal carboxyl esterase (hiCE) is a drug target for ameliorating irinotecan-induced diarrhea. By reducing irinotecan-induced diarrhea, hiCE inhibitors can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed. The hiCE structure has been constructed through homology techniques using hCES1’s crystal structure. The hiCE structure was optimized via molecular dynamics simulations with the most known active hiCE inhibitors docked into the structure. An optimized pharmacophore, derived from the receptor, was then generated. A ligand-based pharmacophore was also generated from a larger set of known hiCE inhibitors. The final hiCE inhibitor predictions were based upon the virtual screening hits from both ligand-based and receptor-based pharmacophore models. The hit rates from the ligand-based and receptor-based pharmacophore models are 88% and 86%, respectively. The final hit rate is 94%. The two models are highly consistent with one another (85%). This proves that both models are reliable. 相似文献
948.
Dr. Shengliang Hu Ruixue Tian Lingling Wu Qing Zhao Prof. Jinlong Yang Prof. Jun Liu Shirui Cao 《化学:亚洲杂志》2013,8(5):1035-1041
Carbon quantum dots (CQDs) were synthesized by heating various carbon sources in HNO3 solution at reflux, and the effects of HNO3 concentration on the size of the CQDs were investigated. Furthermore, the oxygen‐containing surface groups of as‐prepared CQDs were selectively reduced by NaBH4, leading to new surface states. The experimental results show that the sizes of CQDs can be tuned by HNO3 concentration and then influence their photoluminescent behaviors; the photoluminescent properties are related to both the size and surface state of the CQDs, but the photocatalytic activities are determined by surface states alone. The different oxygen‐containing groups on the surface of the CQDs can induce different degrees of the band bending upward, which determine the separation and combination of the electron–hole pairs. The high upward band bending, which is induced by C?O and COOH groups, facilitates separation of the electron–hole pairs and then enhances high photocatalytic activity. In contrast, the low upward band bending induced by C? OH groups hardly prevents the electron–hole pairs from surface recombination and then exhibits strong photoluminescence. Therefore, both the photocatalytic activities and optical properties of CQDs can be tuned by their surface states. 相似文献
949.
The development of electrocatalysts is crucial for renewable energy applications. Metal‐doped graphene hybrid materials have been explored for this purpose, however, with much focus on noble metals, which are limited by their low availability and high costs. Transition metals may serve as promising alternatives. Here, transition metal‐doped graphene hybrids were synthesized by a simple and scalable method. Metal‐doped graphite oxide precursors were thermally exfoliated in either hydrogen or nitrogen atmosphere; by changing exfoliation atmospheres from inert to reductive, we produced materials with different degrees of oxidation. Effects of the presence of metal nanoparticles and exfoliation atmosphere on the morphology and electrocatalytic activity of the hybrid materials were investigated using electron microscopy, energy‐dispersive X‐ray spectroscopy, X‐ray photoelectron spectroscopy, and cyclic voltammetry. Doping of graphene with transition metal nanoparticles of the 4th period significantly influenced the electrocatalysis of compounds important in energy production and storage applications, with hybrid materials exfoliated in nitrogen atmosphere displaying superior performance over those exfoliated in hydrogen atmosphere. Moreover, nickel‐doped graphene hybrids displayed outstanding electrocatalytic activities towards reduction of O2 when compared to bare graphenes. These findings may be exploited in the research field of renewable energy. 相似文献
950.
Dr. Jinsuo Gao Xueying Zhang Yan Yang Jun Ke Prof. Xinyong Li Prof. Yaobin Zhang Prof. Feng Tan Prof. Jingwen Chen Prof. Xie Quan 《化学:亚洲杂志》2013,8(5):934-938
Silanol groups on a silica surface affect the activity of immobilized catalysts because they can influence the hydrophilicity/hydrophobicity, matter transfer, or even transition state in a catalytic reaction. Previously, these silanol groups have usually been passivated by using surface‐passivation reagents, such as alkoxysilanes, bis‐silylamine reagents, chlorosilanes, etc., and surface passivation has typically been found in mesoporous‐silicas‐supported molecular catalysts and heteroatomic catalysts. However, this property has rarely been reported in mesoporous‐silicas‐supported metal‐nanoparticle catalysts. Herein, we prepared an almost‐superhydrophobic SBA‐15‐supported gold‐nanoparticle catalyst by using surface passivation, in which the catalytic activity increased more than 14 times for the reduction of nitrobenzene compared with non‐passivated SBA‐15. In addition, this catalyst can selectively catalyze hydrophobic molecules under our experimental conditions, owing to its high (almost superhydrophobic) hydrophobic properties. 相似文献