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251.
Petrassi HM Johnson SM Purkey HE Chiang KP Walkup T Jiang X Powers ET Kelly JW 《Journal of the American Chemical Society》2005,127(18):6662-6671
Transthyretin (TTR) amyloidogenesis requires rate-limiting tetramer dissociation and partial monomer denaturation to produce a misassembly competent species. This process has been followed by turbidity to identify transthyretin amyloidogenesis inhibitors including dibenzofuran-4,6-dicarboxylic acid (1). An X-ray cocrystal structure of TTR.1(2) reveals that it only utilizes the outer portion of the two thyroxine binding pockets to bind to and inhibit TTR amyloidogenesis. Herein, structure-based design was employed to append aryl substituents at C1 of the dibenzofuran ring to complement the unused inner portion of the thyroxine binding pockets. Twenty-eight amyloidogenesis inhibitors of increased potency and dramatically increased plasma TTR binding selectivity resulted. These function by imposing kinetic stabilization on the native tetrameric structure of TTR, creating a barrier that is insurmountable under physiological conditions. Since kinetic stabilization of the TTR native state by interallelic trans suppression is known to ameliorate disease, there is reason to be optimistic that the dibenzofuran-based inhibitors will do the same. Preventing the onset of amyloidogenesis is the most conservative strategy to intervene clinically, as it remains unclear which of the TTR misassembly intermediates results in toxicity. The exceptional binding selectivity enables these inhibitors to occupy the thyroxine binding site(s) in a complex biological fluid such as blood plasma, required for inhibition of amyloidogenesis in humans. It is now established that the dibenzofuran-based amyloidogenesis inhibitors have high selectivity, affinity, and efficacy and are thus excellent candidates for further pharmacologic evaluation. 相似文献
252.
Joseph P. A. Harrity Harry Adams Mark W. Davies Robert A. J. Wybrow Christopher N. Johnson 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(3):o168-o169
A novel [3+2]‐cycloaddition reaction of alkynylboronates and nitrile oxides gave the title compound, C22H32BNO3, as a single regioisomer. The X‐ray crystal structure analysis of this compound shows two independent molecules in the asymmetric unit, each with approximately coplanar isoxazole and boronate rings. 相似文献
253.
High-speed peak matching algorithm for retention time alignment of gas chromatographic data for chemometric analysis 总被引:5,自引:0,他引:5
A rapid retention time alignment algorithm was developed as a preprocessing utility to be used prior to chemometric analysis of large datasets of diesel fuel profiles obtained using gas chromatography (GC). Retention time variation from chromatogram-to-chromatogram has been a significant impediment against the use of chemometric techniques in the analysis of chromatographic data due to the inability of current chemometric techniques to correctly model information that shifts from variable to variable within a dataset. The alignment algorithm developed is shown to increase the efficacy of pattern recognition methods applied to diesel fuel chromatograms by retaining chemical selectivity while reducing chromatogram-to-chromatogram retention time variations and to do so on a time scale that makes analysis of large sets of chromatographic data practical. Two sets of diesel fuel gas chromatograms were studied using the novel alignment algorithm followed by principal component analysis (PCA). In the first study, retention times for corresponding chromatographic peaks in 60 chromatograms varied by as much as 300 ms between chromatograms before alignment. In the second study of 42 chromatograms, the retention time shifting exhibited was on the order of 10 s between corresponding chromatographic peaks, and required a coarse retention time correction prior to alignment with the algorithm. In both cases, an increase in retention time precision afforded by the algorithm was clearly visible in plots of overlaid chromatograms before and then after applying the retention time alignment algorithm. Using the alignment algorithm, the standard deviation for corresponding peak retention times following alignment was 17 ms throughout a given chromatogram, corresponding to a relative standard deviation of 0.003% at an average retention time of 8 min. This level of retention time precision is a 5-fold improvement over the retention time precision initially provided by a state-of-the-art GC instrument equipped with electronic pressure control and was critical to the performance of the chemometric analysis. This increase in retention time precision does not come at the expense of chemical selectivity, since the PCA results suggest that essentially all of the chemical selectivity is preserved. Cluster resolution between dissimilar groups of diesel fuel chromatograms in a two-dimensional scores space generated with PCA is shown to substantially increase after alignment. The alignment method is robust against missing or extra peaks relative to a target chromatogram used in the alignment, and operates at high speed, requiring roughly 1 s of computation time per GC chromatogram. 相似文献
254.
Geng J Singh C Shephard DS Shaffer MS Johnson BF Windle AH 《Chemical communications (Cambridge, England)》2002,(22):2666-2667
A simple method for the synthesis of high purity single wall carbon nanotubes has been developed by using nickel formate as a precursor for the formation of nearly mono-dispersed nickel seed-nanoparticles as catalysts in the CVD growth process. 相似文献
255.
256.
A reversed-phase high-performance liquid chromatographic method with electrochemical detection has been adapted for the determination of picogram concentrations of norepinephrine and epinephrine in bovine plasma and milk. This method has been used to monitor the levels of these catecholamines when lactating cows are exposed to heat stress under controlled conditions. In response to heat stress, epinephrine concentrations in milk and plasma were similar. However, norepinephrine concentrations in milk were one tenth of that in plasma. 相似文献
257.
V. Karimäki R. Kinnunen M. Korkea-aho J. Tuominiemi G. W. van Apeldoorn D. Harting D. J. Holthuizen B. J. Pijlgroms P. Johnson P. Mason P. Michaelides Ch. Michaelidou H. Muirhead G. D. Patel G. Ekspong T. Moa S. Nilsson 《Zeitschrift fur Physik C Particles and Fields》1981,9(2):117-129
Inclusive production of ?0,K *±(892), andf is studied in \(\bar p\) p interactions at 12 GeV/c. The inclusive cross sections for ?0,K *±(892), andf are found to be 6.7±0.3 mb, 1.0±0.2 mb, and 1.4±0.3 mb, respectively. The differential cross sections are presented as a function of c.m. rapidity, Feynmanx and square of the transverse momentump T 2 . Comparison with the correspondingpp data shows some interesting differences which can be attributed to the \(\bar p\) p annihilation. The results are compared with the predictions of the quark fusion model. 相似文献
258.
Silbernagel KM Jechorek RP Kaufer AL Johnson RL Aleo V Brown B Buen M Buresh J Carson M Franklin J Ham P Humes L Husby G Hutchins J Jechorek R Jenkins J Kaufer A Kexel N Kora L Lam L Lau D Leighton S Loftis M Luc S Martin J Nacar I Nogle J Park J Schultz A Seymore D Smith C Smith J Thou P Ulmer M Voss R Weaver V 《Journal of AOAC International》2005,88(3):750-760
A multilaboratory study was conducted to compare the VIDAS LIS immunoassay with the standard cultural methods for the detection of Listeria in foods using an enrichment modification of AOAC Official Method 999.06. The modified enrichment protocol was implemented to harmonize the VIDAS LIS assay with the VIDAS LMO2 assay. Five food types--brie cheese, vanilla ice cream, frozen green beans, frozen raw tilapia fish, and cooked roast beef--at 3 inoculation levels, were analyzed by each method. A total of 15 laboratories representing government and industry participated. In this study, 1206 test portions were tested, of which 1170 were used in the statistical analysis. There were 433 positive by the VIDAS LIS assay and 396 positive by the standard culture methods. A Chi-square analysis of each of the 5 food types, at the 3 inoculation levels tested, was performed. The resulting average Chi square analysis, 0.42, indicated that, overall, there are no statistical differences between the VIDAS LIS assay and the standard methods at the 5% level of significance. 相似文献
259.
Lackovic K Angove MJ Wells JD Johnson BB 《Journal of colloid and interface science》2004,269(1):37-45
The adsorption of cadmium onto goethite in the presence of citric acid was measured as a function of pH and cadmium concentration at 25 degrees C. Potentiometric titrations were also performed on the system. Cadmium adsorption onto goethite was enhanced above pH 4 in the presence of 50 microM, 100 microM and 1 mM citric acid. While there was little difference between the enhancements caused by 50 and 100 microM citric acid below pH 6, above pH 6 further enhancement is seen in the presence of 100 microM citric acid. When 1 mM citric acid was present, the enhancement of cadmium adsorption was greater below pH 6, with increased Cd(II) adsorption down to pH 3.5. However, above pH 6, 1 mM of citric acid caused slightly less enhancement than the lower citric acid concentrations. ATR-FTIR spectra of soluble and adsorbed citrate-cadmium species were measured as a function of pH. At pH 4.6 there was very little difference between the ternary Cd(II)-citric acid-goethite spectrum and the binary citric acid-goethite spectrum. However, spectra of the ternary system at pH 7.0 and 8.7 indicated the presence of additional surface species. Further analysis of the spectra suggested that these were metal-ligand outer-sphere complexes. Data from the adsorption experiments and potentiometric titrations of the ternary Cd(II)-citric acid-goethite system were fitted by an extended constant-capacitance surface complexation model. The spectroscopic data were used to inform the choice of surface species. Three reactions in addition to those for the binary Cd(II)-goethite and citric acid-goethite systems were required to describe all of the data. They were [formula in text], [formula in text], and [formula in text]. Neither the spectroscopy nor the modeling suggested the formation of a ternary inner-sphere complex or a surface precipitate under the conditions used in this study. 相似文献
260.
D. Atkinson M. Kaekebeke J. S. Frederiksen P. W. Johnson 《Communications in Mathematical Physics》1976,51(1):67-84
We demonstrate the existence of a solution of the nonlinear pion-pion equations that incorporate crossing symmetry, unitarity andl-plane meromorphy. In particular, we show how to guarantee the boundedness of the partial waves ass, even when some Regge trajectories rise beyond unity. 相似文献