Synthesis and Properties of D-Thymidylyl (3'→5')L-Thymidine (D/L-TpT)

Inrecentyearsmuchefforthasbeenspenttodevelopoligonucleotideanalogsashighlyselectivepharmaceuticalagentstoblockexpressionofdisease-associatedproteins'-'.andtheseefT'ortshaveresultedilltheapprovaloffomiversensodium(vitravene',"),thefirstantisensedrug,byFDAinAugust1998fortreatmentofAIDSpatientswithcytomegalovirus(CMV)-inducedretinitis6.However,thegreatpotentialofantisenseoligonucleotidesasantiviralandanticanceragentsiscompromisedbytheirnucleasesusceptibilityandlowcellmembranepermeability.L-D…     

纳米级镍铁同步处理Cr(VI)和p-NCB的研究

采用纳米级镍/铁双金属体系同步处理含Cr(VI)和p-NCB的废水,考察了反应温度、初始pH值和Cr(VI)、p-NCB浓度变化以及Ni(II)存在对处理效率的影响.结果表明:纳米级镍/铁双金属应用于Cr(VI)和p-NCB同步处理,可以取得良好的去除效率.反应产物为Cr(III)和苯胺.Ni(II)可以促进p-NCB的还原降解,而水中的Cr(VI)会与p-NCB起竞争作用,从而抑制p-NCB的还原降解.     

Structural elucidation of metabolites of ginkgolic acid in rat liver microsomes by ultra‐performance liquid chromatography/electrospray ionization tandem mass spectrometry and hydrogen/deuterium exchange

Ginkgolic acids have been shown to possess allergenic as well as genotoxic and cytotoxic properties. The question arises whether the metabolism of ginkgolic acids in the liver could decrease or increase their toxicity. In this study, the in vitro metabolism of ginkgolic acid (15:1, GA), one component of ginkgo acids, was investigated as a model compound in Sprague‐Dawley rat liver microsomes. The metabolites were analyzed by ultra‐performance liquid chromatography coupled with photodiode array detector/negative‐ion electrospray ionization tandem mass spectrometry (UPLC‐PDA/ESI‐MS/MS) and hydrogen/deuterium (H/D) exchange. The result showed that the benzene ring remained unchanged and the oxidations occurred at the side alkyl chain in rat liver microsomes. At least eight metabolites were found. Among them, six phase I metabolites were tentatively identified. This study might be useful for the investigation of toxicological mechanism of ginkgolic acids. Copyright © 2009 John Wiley & Sons, Ltd.     

James空间的推广

R.H.Lohman和P.G.Casazza[2]就自反的、具有对称的块P——Hilbert基的Banach空间进行了讨论,给出了一阶次自反Banach空间的一种构造方法。本文在一类具有IS型基的Banach空间上进行了推广,并给出了构造一阶次自反空间的更一般性的方法。 以下记号S、的意义同[2],文中IS序列、ESA序列、SA序列及单调基、正规基的定义可见[2]、[3]。并总设E是Banach空间,{x_i}是E之IS型单调正规基。 一般的James空间定义类似[2],区别在于对于a=(a_i)∈S和我们定义:     

分次环的有限正规扩张

本文研究了群分次环的有限正规分次扩张问题．利用经典环论方法，得到一个群分次环与其有限正规分次扩张环之间关于分次Jacobson根和分次素根的关系，同时，给出了分次情形的Cutting down定理和Lying over定理．     

Gradient estimates in Orlicz space for nonlinear elliptic equations

In this paper we generalize gradient estimates in Lp space to Orlicz space for weak solutions of elliptic equations of p-Laplacian type with small BMO coefficients in δ-Reifenberg flat domains. Our results improve the known results for such equations using a harmonic analysis-free technique.     

A class of Sierpinski carpets with overlaps

Based on a scheme by Lau and Ngai, a sufficient and necessary condition for an IFS of contractive similitudes to satisfy the open set condition is given. A class of Sierpinski carpets with parameters (λ₁,λ₂) is then investigated.     

A note on testing for constant hazard against a change-point alternative

Summary The problem of testing for constant hazard against a change-point alternative is considered. It is shown that this problem is related to another one in quality control. Based on this relationship, a test is proposed. The main advantages of this test are its computational simplicity and the ready availability of small and large sample distribution theory.