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21.
Plieger PG Ehler DS Duran BL Taylor TP John KD Keizer TS McCleskey TM Burrell AK Kampf JW Haase T Rasmussen PG Karr J 《Inorganic chemistry》2005,44(16):5761-5769
The ligand 4,5-dicarboxyimidazole (H(2)DCI) and its methyl derivative 1-methyl-4,5-dicarboxyimidazole (H(2)MDCI) have been shown to bind to Be(II) forming a zwitterionic species that has been structurally characterized. A new dicarboxyimidazole-based polymer has been prepared and its Be-binding properties have been studied using NMR ((1)H and (9)Be) and fluorescence spectroscopy; it represents a rare example of beryllium binding to a polymer. Models of the mononuclear and polymeric Be(II)-binding sites have been studied using density functional theory (DFT), and the (9)Be NMR chemical shifts of these model materials have been calculated for the purpose of direct comparison to experimentally observed values. Differences in the binding modes of the mononuclear and polymeric species are discussed. 相似文献
22.
Gibson SE Kaufmann KA Loch JA Steed JW White AJ 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(8):2566-2576
Understanding the interaction of chiral ligands, alkynes, and alkenes with cobaltcarbonyl sources is critical to learning more about the mechanism of the catalytic, asymmetric Pauson-Khand reaction. We have successfully characterized complexes of the type [Co2(alkyne)(binap)(CO)4] (BINAP=(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine)) and shown that diastereomer interconversion occurs under Pauson-Khand reaction conditions when alkyne=HC[triple bond]CCO2Me. Attempts to isolate [Co2(alkyne)(binap)(CO)x] complexes with coordinated alkenes led to the formation of cobaltacyclopentadiene species. 相似文献
23.
In condensed phase chemistry, the solvent can have a significant impact on everything from yield to product distribution to mechanism. With regard to photo-induced processes, solvent effects have been well-documented for charge-transfer states wherein the redistribution of charge subsequent to light absorption couples intramolecular dynamics to the local environment of the chromophore. Ligand-field excited states are expected to be largely insensitive to such perturbations given that their electronic rearrangements are localized on the metal center and are therefore insulated from so-called outer-sphere effects by the ligands themselves. In contrast to this expectation, we document herein a nearly two-fold variation in the time constant associated with the 5T2 → 1A1 high-spin to low-spin relaxation process of tris(2,2′-bipyridine)iron(ii) ([Fe(bpy)3]2+) across a range of different solvents. Likely origins for this solvent dependence, including relevant solvent properties, ion pairing, and changes in solvation energy, were considered and assessed by studying [Fe(bpy)3]2+ and related derivatives via ultrafast time-resolved absorption spectroscopy and computational analyses. It was concluded that the effect is most likely associated with the volume change of the chromophore arising from the interconfigurational nature of the 5T2 → 1A1 relaxation process, resulting in changes to the solvent–solvent and/or solvent–solute interactions of the primary solvation shell sufficient to alter the overall reorganization energy of the system and influencing the kinetics of ground-state recovery.Time-resolved spectroscopic measurements of ground-state recovery for [Fe(bpy)3]2+ reveal that the solvent can induce an outer-sphere reorganization energy effect on excited-state dynamics involving metal-centered ligand-field electronic states. 相似文献
24.
Chen TF Yoder JD Hruby DE 《European journal of mass spectrometry (Chichester, England)》2004,10(4):501-508
Myristoylpeptides were synthesized in order to determine if a neutral loss of 210 Da, C14H26O (the mass of the myristoyl moiety), was universal and observable by both liquid chromatography electrospray ionization quadrupole ion trap (LC-ESI-QIT) and matrix-assisted laser desorption/ionization time-of-flight time-of-flight (MALDI-ToF/ToF) mass spectrometry. Myristoylation was successfully introduced on the N-terminus, internally on the amino group of lysine and arginine. Larger peptides and the arginine compounds needed elevated temperatures for myristoylation. To our knowledge, this is the first report of a chemically-synthesized myristoylated arginine in a peptide. Collision energy studies for the LC-ESI-QIT instrument showed that modified peptides and a loss of 210 Da could be detected under commonly used conditions (energy level between 30 and 42%) with picomole amounts of sample. The loss of myristoyl moiety is observed on the MALDI-Tof/Tof mass spectrometer as well. Due to the hydrophobic properties of the myristoyl moiety, it is not surprising that the modified peptides all formed at least dimers, and in some cases trimers. We were also able to distinguish a mixture of two mono-myristoylated peptides. MS3 data from the LC-ESI-QIT instrument on a di-myristoylated peptide indicates the loss of 210 Da at either the N-terminus or lysine. We were also able to analyze a mixture of modified and unmodified peptides on the MALDI-ToF/ToF instrument. The data presented in this paper demonstrates the constant neutral loss of the 210 Da, C14H26O, from both N-terminally and internally myristoylated peptides can be identified unambiguously using LC-ESI-QIT or MALDI-ToF/ToF mass spectrometers. This will be a useful tool in determining the myristoylation status of candidate proteins after enzyme digestion, and in elucidating the modification sites of internal myristoyl proteins. 相似文献
25.
Thomas F. Jenny Jennifer Horlacher Nicoletta Previsani Steven A. Benner 《Helvetica chimica acta》1992,75(6):1944-1954
A set of derivatives of cyclopentaneacetic acid cis-substituted at position 3 by nucleoside bases (both purines and pyrimidines) were prepared and characterized (see 11, 14 , and 23a, b; Schemes 2–4). These molecules are carbocyclic analogs of 2′,3′-dideoxy-5′-homonucleosides. In this synthesis, the skeleton was constructed from norbornanone and a novel method based on Mitsunobu chemistry used for the introduction of nucleoside-base substituents. The scope of this method was further explored via the preparation of a cyclobutyl analog of dideoxyguanosine (see 17 , Scheme 3). 相似文献
26.
Semiempirical calculations, at the PM3 level provided within the Winmopac v2.0 software package, are used to geometrically optimize and determine the absolute energies (heats of formation) of a variety of C(20) isomers that are predicted to exist in and around the ring and cage isomers. Using the optimized Cartesian coordinates for the ring and the cage isomers, a saddle-point calculation was performed. The resulting energy profile, consisting of a series of peaks and valleys, is used as a starting point for the identification and location of fifteen additional isomers of C(20) that are predicted to be energetically stable, both via geometry optimizations and force constant analysis. These additional isomers were subsequently determined to lie adjacent to one another on the potential surface and establish a step-wise transformation between the ring and the cage. Transition-state optimization of the Cartesian coordinates at the saddle point between adjacent isomers was performed to quantify the energy of the transition state. The step-wise process from one isomer to another, which extends out over the three-dimensional surface, is predicted to require approximately 15% less energy than that of the direct, two-dimensional transformation predicted in the bowl-cage profile. However, the net atomic rearrangement for the step-wise process is about four times greater than that of the direct process. Although less in energy, the amount of atomic rearrangement in the step-wise process would make the occurrence of such a route prohibitive. Utilizing the direct distance separating the three primary isomers (ring, bowl, cage), the method of triangulation is performed to quantitatively position other C(20) structures on the potential surface, relative to the ring, bowl, and cage isomers. 相似文献
27.
Schormann M Garratt S Hughes DL Green JC Bochmann M 《Journal of the American Chemical Society》2002,124(38):11266-11267
The reaction of the tin-substituted propene Me3Sn(R)CHCH=CHR (R = SiMe3) with MCl4 in dichloromethane in the presence of Me3SnCl gives the first examples of isolable sec-alkyl carbocation salts, [HC{CH(R)SnMe3}2]+M2Cl9- (M = Zr, Hf). The compounds are thermally stable and, unlike previously isolated trialkyl carbocations, do not require superacidic media or weakly coordinating anions for stability. The crystal structure and DFT calculations suggest polarization of the Sn substituents and hyperconjugation as the reason for the unexpected stability. The stabilizing effect of tin is significantly stronger than that of Si. The carbocations are effective initiators for the polymerization of isobutene, isoprene, and alpha-methylstyrene. 相似文献
28.
Paul D. Beer Zheng Chen Philip A. Gale Jennifer A. Heath Rachel J. Knubley Mark I. Ogden Michael G. B. Drew 《Journal of inclusion phenomena and macrocyclic chemistry》1994,19(1-4):343-359
The synthesis, metal, ammonium and alkyl ammonium cation coordination chemistry and electrochemical recognition studies of new diester-and diamide-calix[4]arenediquinone receptors are described. In addition the synthesis and coordination properties of a novel diamide benzo-15-crown-5-calix[4]arene molecule is reported.This paper is dedicated to the commemorative issue on the 50th anniversary of calixarenes. 相似文献
29.
Claude Balny Jennifer Canva Pierre Douzou Jean Bourdon 《Photochemistry and photobiology》1969,10(6):375-382
Abstract— Chemiluminescence and photochemiluminescence of systems generating excited (singlet) molecular oxygen has been studied at low temperature in fluid media. A possible interpretation is proposed: that dimers of singlet oxygen are directly or indirectly responsible for the observed emission, the species [1 δg +1 σg+ ] predominating. Energy transfer to a fluorescent molecule is possible only when conditions of spectral overlap, required for transfer by inductive resonance, are fulfilled. Evidence is also presented for the formation of a transient complex between oxygen and a sensitiser or acceptor molecule [S…O2 ], which is the precursor of singlet oxygen in these systems. However, other possible mechanisms cannot be excluded. 相似文献
30.
Immunoassays have traditionally relied on antibodies as diagnostic probes. Their use outside of a laboratory, however, may be problematic because antibodies are often unstable in severe environmental conditions. Environmental monitoring requires thermostable probes, such as landscape phage, that carry thousands of foreign peptides on their surfaces, are superior to antibodies, and can operate in non-controlled conditions. While parent wild-type phage are known to be extremely stable in various media at high temperatures, no work has been done to demonstrate the stability of landscape phage probes. We examined the thermostability of a landscape phage probe and a monoclonal antibody specific for -galactosidase in parallel in an enzyme-linked immunosorbent assay (ELISA) format. They were both stable for greater than six months at room temperature, but at higher temperatures the antibody degraded more rapidly than the phage probe. Phage retained detectable binding ability for more than six weeks at 63 °C, and three days at 76 °C. The activation energy of phage degradation was determined to be 1.34×105 J/mol. These results confirm that phage probes are highly thermostable and can function even after exposure to high temperatures during shipping, storage and operation. 相似文献