Analytical Solution Incorporating History-Dependent Processes for Quick Assessment of Capillary Trapping During CO<Subscript>2</Subscript> Geological Storage

Carbon storage in saline formations is considered as a promising option to ensure the necessary decrease of CO₂ anthropogenic emissions. Its industrial development in those formations is above all conditioned by its safety demonstration. Assessing the evolution of trapped and mobile CO₂ across time is essential in the perspective of reducing leakage risks. In this work, we focus on residual trapping phenomenon occurring during the wetting of the injected CO₂ plume. History dependent effects are of first importance when dealing with capillary trapping. We then apply the classical fractional flow theory (Buckley–Leverett type model) and include trapping and hysteresis models; we derive an analytical solution for the temporal evolution of saturation profile and of CO₂ trapped quantity when injecting water after the gas injection (“artificial imbibition”). The comparison to numerical simulations for different configurations shows satisfactory match and justifies, in the case of industrial CO₂ storage, the assumptions of incompressible flow with no consideration of capillary pressure. The obtained analytical solution allows the quick assessment of both the quantity and the location of mobile gas left during imbibition.     

Multiresidue chromatographic method for the determination of macrolide residues in muscle by high-performance liquid chromatography with UV detection.

A high-performance liquid chromatographic (HPLC) method for the simultaneous determination of tilmicosin, tylosin, spiramycin, and its major metabolite neospiramycin was developed that is suitable for porcine, bovine, and poultry muscles. Macrolide residues were extracted from muscle with acetonitrile, fat was removed by liquid-liquid extraction with isooctane, and the extract was then cleaned on Bond Elut C18 cartridges. The HPLC separation was performed on an Inertsil ODS3 C18 column (150 x 4 mm) with 0.05% trifluoroacetic acid-acetonitrile in a gradient mode. Two different chromatographic gradients were used for tilmicosin-tylosin and spiramycin-neospiramycin, and the detection wavelengths were 287 and 232 nm, respectively. The method was validated from 1/2 the maximum residue limit (MRL) to 4 times the MRL with pork muscle samples. Mean recoveries were 60, 63.5, 51, and 42% for tilmicosin, tylosin, spiramycin, and neospiramycin, respectively. The detection limits are 15 micrograms/kg for tilmicosin and tylosin, 30 micrograms/kg for spiramycin, and 25 micrograms/kg for neospiramycin. Linearity, precision, and accuracy of the method were also tested.     

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of representative library members are measured in order to evaluate the use of these scaffolds for the generation of lead-like molecules to be used in targeting the central nervous system. The solid-phase synthesis of a 1976-membered library of spirocyclic azetidines is also described.     

Fourier holograms recorded and decoded in polychromatic light

This paper describes a recording and reconstruction method applied to two-dimension Fourier holography, in which the illumination at the recording stage is spatially coherent and temporally incoherent. The various chromatic components of the information to be recorded in the hologram are spread along a direction orthogonal to the entrance slit of a spectroscope that behaves as scanning pupil performing a chromatic coding. The message, both spatially and temporally coded, can be reconstructed by using a conventional process, the light source being still polychromatic.     

Pozzolanic reactivity of silico-aluminous fly ash

For some years it has been possible to control the particle size of fly ashes, by-products of thermal power stations. Incorporating these very fine particles (obtained by grinding and/or pneumatic selection) improves the physical-mechanical characteristics of mortars and concretes. In this study, we measured the lime consumption of the various fractions (granulometric and densimetric) and identified by X-ray diffraction the neoformed phases by the pozzolanic reaction, to show that it is not sufficient to simply define the pozzolanicity of products based on lime consumption since it does not take into account the nature of the phases formed. The size of the particles used in the test samples also has a determining effect on the quantity of lime consumed. Before comparing results, it is necessary to ensure that the size of the particles (of the global ash and its constituents) be the same. Two distinct neoformed phases appear: CSH in the largest granular fractions (d>40 μm) and C<3AH6 in the smaller fractions.     

as-Triazino[4,5-α] indoles. III. Etude des substitutions électrophiles des triazinoindolones

Electrophilic substitution reactions of the 1- and 4-triazino-indolones were made on lactamic nitrogen with methyl sulphate or benzyl chloride and on the homocycle with bromine or nitric acid. BrominatJon and nitration reactions gave either mono-substitutions on position 10 or disubstitutions on position 7 and 10 or 9 and 10 or polysubstitutions leading to mixtures of tri-and tetrasubstituted compounds. The structure of the derivatives was determined by nmr, study of the NOE effect and unequivocal synthesis.     

Cryptanalysis of HFE, multi-HFE and variants for odd and even characteristic

We investigate in this paper the security of HFE and Multi-HFE schemes as well as their minus and embedding variants. Multi-HFE is a generalization of the well-known HFE schemes. The idea is to use a multivariate quadratic system—instead of a univariate polynomial in HFE—over an extension field as a private key. According to the authors, this should make the classical direct algebraic (message-recovery) attack proposed by Faugère and Joux on HFE no longer efficient against Multi-HFE. We consider here the hardness of the key-recovery in Multi-HFE and its variants, but also in HFE (both for odd and even characteristic). We first improve and generalize the basic key recovery proposed by Kipnis and Shamir on HFE. To do so, we express this attack as matrix/vector operations. In one hand, this permits to improve the basic Kipnis-Shamir (KS) attack on HFE. On the other hand, this allows to generalize the attack on Multi-HFE. Due to its structure, we prove that a Multi-HFE scheme has much more equivalent keys than a basic HFE. This induces a structural weakness which can be exploited to adapt the KS attack against classical modifiers of multivariate schemes such as minus and embedding. Along the way, we discovered that the KS attack as initially described cannot be applied against HFE in characteristic 2. We have then strongly revised KS in characteristic 2 to make it work. In all cases, the cost of our attacks is related to the complexity of solving MinRank. Thanks to recent complexity results on this problem, we prove that our attack is polynomial in the degree of the extension field for all possible practical settings used in HFE and Multi-HFE. This makes then Multi-HFE less secure than basic HFE for equally-sized keys. As a proof of concept, we have been able to practically break the most conservative proposed parameters of multi-HFE in few days (256 bits security broken in 9 days).     

Pyrrolo[1,2-d]triazines-1,2,4. II. Etude des pyrrolo[1,2-d]triazinones-1 et -4

The synthesis of 1,2-dihydro-1-oxopyrrolo[1,2-d]-1,2,4-triazines was achieved by rearrangement of 2-pyrrolyloxadiazoles under alkaline conditions or by cyclisation of pyrrole N-ethoxymethylidene hydrazides. The cyclisation of the N-carbethoxy hydrazone of the pyrrole-2-carboxaldehyde gave the 3,4-dihydro-4-oxopyrrolo[1,2-d]-1,2,4-triazine. Electrophilic substitution reactions of the 1- and 4-pyrrolotriazinones were made either on the lactam nitrogen with methyl sulphate, benzyl chloride and monochloroacetic acid or on the pyrrole ring with bromine and nitric acid. The structure of the derivatives was determined by ¹H nmr.