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11.
Jorma Roine Matti Murtomaa Markko Myllys Jarno Salonen 《Journal of Electrostatics》2012,70(5):428-437
The feasibility of electroencapsulation of mesoporous silicon (PSi) micro- and nanoparticles as a method to seal the PSi particles in mechanically processable solid units, and to facilitate time and site specific drug release from the pores of PSi particles, is of interest in the present work. Suitable microcapsules and micromatrix particles were produced in a single-step process using a setup with two electrospraying nozzles kept at high electric potentials of opposite polarities. The structures of the produced particles were analyzed by microscope and X-ray micro- and nanotomography imaging, and optimization of the electroencapsulation process production efficiency is discussed. 相似文献
12.
Ruusunen Jarno Ihalainen Mika Koponen Tarmo Torvela Tiina Tenho Mikko Salonen Jarno Sippula Olli Joutsensaari Jorma Jokiniemi Jorma Lähde Anna 《Journal of nanoparticle research》2014,16(2):1-11
Enteric-coated formulations can delay the release of drugs until they have passed through the stomach. However, high concentration of drugs caused by rapidly released in the small intestine leads to the intestinal damage, and frequent administration would increase the probability of missing medication and reduce the patient compliance. To solve the above-mentioned problems, aspirin-loaded enteric-coated sustained-release nanoparticles with core–shell structure were prepared via one-step method using coaxial electrospray in this study. Eudragit L100-55 as pH-sensitive polymer and Eudragit RS as sustained-release polymer were used for the outer coating and inner core of the nanoparticles, respectively. The maximum loading capacity of nanoparticles was 23.66 % by changing the flow rate ratio of outer/inner solutions, and the entrapment efficiency was nearly 100 %. Nanoparticles with core–shell structure were observed via fluorescence microscope and transmission electron microscope. And pH-sensitive and sustained drug release profiles were observed in the media with different pH values (1.2 and 6.8). In addition, mild cytotoxicity in vitro was detected, and the nanoparticles could be taken up by Caco-2 cells within 1.0 h in cellular uptake study. These results indicate that prepared enteric-coated sustained-release nanoparticles would be a more safety and effective carrier for oral drug delivery. 相似文献
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Krystian L. Wlodarczyk Jarno J. J. Kaakkunen Pasi Vahimaa Duncan P. Hand 《Applied Physics A: Materials Science & Processing》2014,116(1):111-118
An approach for laser marking surfaces using a liquid–crystal-based spatial light modulator (LC-SLM) for beam patterning and manipulation is presented, designed to avoid the speckle interference problem which is a typical drawback of current SLM-based laser marking processes. In our approach, the LC-SLM is used to generate complex two-dimensional micropatterns (e.g., 20 × 20 datamatrices) with overall dimensions of < 320 by 320 μm. The micropatterns are generated in a series of 16 steps, using a Fresnel zone lens (FZL) combined with a computer-generated hologram (CGH); for each step the whole kinoform (FZL + CGH) is spatially shifted off-axis by a different amount of pixels to build-up the required pattern. In comparison with other SLM-based laser marking approaches already reported in the literature, our method not only eliminates (or at least significantly reduces) unwanted speckle interference but also reduces the laser power required for marking. 相似文献
15.
Jarno J. M. Weemers Dr. Jelena Wiecko Dr. Evgeny A. Pidko Manuela Weber Dr. Martin Lutz Prof. Dr. Christian Müller 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(43):14458-14469
The novel atropisomeric pyridine derivative rac‐ 10 has been synthesized and structurally characterized. In contrast to its phosphorus analogue 3 , axially chiral 10 has a considerably lower rotational barrier as estimated by DFT calculations. However, the presence of the two enantiomers could be confirmed by means of chiral analytical HPLC analysis and by protonation experiments with a chiral acid. Compound rac‐ 10 could be further dehydrogenated by treatment with DDQ to the benzo(h)quinoline derivative rac‐ 12 . This conversion failed for the phosphorus analogue rac‐ 3 . Interestingly, although 2,4,6‐triarylphosphinines undergo facile C? H activation with [Cp*IrCl2]2 in the presence of NaOAc, this reaction does not proceed with the corresponding pyridine derivatives. On the other hand, the latter ones can be selectively ortho‐metalated with Pd(OAc)2, leading to acetate‐bridged dimeric species, which could be unambiguously confirmed by means of X‐ray crystal structure analysis. The treatment of phosphinines with Pd(OAc)2 led instead to the formation of the unusual cofacial oxidative coupling products 16 and 17 , which consist of a phosphorus‐containing cage structure. 相似文献
16.
The significant similarity between MF3, MF4–, and M2F7– (M = Au, Br) is studied using quantum chemical methods. It is expected that compounds containing Au3F10– anions are likely to be stable. A theoretical background for the ongoing attempts of their synthesis is provided by calculations on the stabilities and molecular structures of various bromine and gold anions with the general composition of MnF3n+1– (n = 1, 2, 3, 4). The anions show unexpected differences and peculiarities in their energetically preferable molecular structures. Different chain‐like structures are predicted as the global minima for the hypothetical Au3F10– and Br4F13– anions. 相似文献
17.
We present a method for measuring powder resistivity as a function of moisture using a one-step process. The developed new resistivity cell consists of narrow horizontal electrode surrounded by a grounded guard electrode and simultaneous measurement of humidity within the powder bed. The system was modeled using computer simulations. As an example, resistivities of three different lactoses, wheat flour and quartz are presented. Resistivity was found to decrease several orders of magnitude between 10 RH% and 90 RH%. Simulated results showed that if no guard plate is used, measurement errors caused by humidity gradient are of order of magnitude. 相似文献
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Joakim Riikonen Jarno Salonen Vesa-Pekka Lehto 《Journal of Thermal Analysis and Calorimetry》2011,105(3):811-821
Thermoporometry is a relatively new method of characterising porous properties of nanostructured materials based on observation of solid–liquid phase transitions of materials confined in pores. It provides several advantages over the conventional characterisation methods, mercury porosimetry and gas sorption. The advantages include possibility of using short measurement times, non-toxic chemicals and wet samples. In addition, complicated sample preparation and specialised instruments are not required. Therefore, it has a great potential of becoming a widely utilised characterisation method, although its potential has not yet been widely realised. In recent years, there has been a significant increase in research activities regarding the method. In the first part of the review, we introduce thermoporometry and review related results of the confinement effects on materials and their solid–liquid phase transition. 相似文献
19.
Felix Schmidt-Stein Jan-Frederik Gnichwitz Jarno Salonen Robert Hahn Andreas Hirsch Patrik Schmuki 《Electrochemistry communications》2009,11(10):2000-2003
This work reports on an electrochemical system which allows the control of surface wettability properties by voltage induced changes in contact angle (Θ) of ΔΘ 50°. For this we used conductive TiO2 nanotubular layers that were modified with ferrocene coupled to the TiO2 surface via triethoxysilane. To enhance the hydrophobic character of the nanotubular TiO2 surface, also mixed organic monolayers namely perfluorotriethoxysilane, were explored. Formation of the ferrocene and mixed organic monolayer was confirmed by X-ray-photoelectron-spectroscopy (XPS). Contact angle combined with electrochemical measurements show that ferrocene in these monolayers can successfully be switched from Fe2+ to Fe3+ and that this change in the redox state considerably alters the wetting properties. Using a conductive nanotube substrate allows us to amplify this change by a factor of more than 10, and thus this surface can be used to trigger significant wetting alterations. 相似文献
20.
Jarno Talponen 《Topology and its Applications》2009,156(5):915-925
We will introduce the countable separation property (CSP) of Banach spaces X, which is defined as follows: X has CSP if each family E of closed linear subspaces of X whose intersection is the zero space contains a countable subfamily E0 with the same intersection. All separable Banach spaces have CSP and plenty of examples of non-separable CSP spaces are provided. Connections of CSP with Marku?evi?-bases, Corson property and related geometric issues are discussed. 相似文献