爆炸荷载作用下钢筋混凝土梁的动力响应及破坏形态分析

对基于Timoshenko梁理论建立的非线性动力有限元法作了改进。根据压区理论得到混凝土的平均剪应力和平均剪应变关系,建立了能反映箍筋的抗剪作用的材料模型;此外,对结构在爆炸荷载作用下可能出现的各种响应现象进行了描述,以准确地预测梁破坏时不同位置截面上钢筋和混凝土的受力、变形及破坏情况。应用改进的材料模型,对爆炸荷载作用下的五个钢筋混凝土试验梁的动力响应和破坏形态进行了数值模拟,结果表明,该数值方法能较好地模拟钢筋混凝土梁的弯曲、弯剪和剪切等破坏形态。     

Recent Advances in Synergistic Antitumor Effects Exploited from the Inhibition of Ataxia Telangiectasia and RAD3-Related Protein Kinase (ATR)

As one of the key phosphatidylinositol 3-kinase-related kinases (PIKKs) family members, ataxia telangiectasia and RAD3-related protein kinase (ATR) is crucial in maintaining mammalian cell genomic integrity in DNA damage response (DDR) and repair pathways. Dysregulation of ATR has been found across different cancer types. In recent years, the inhibition of ATR has been proven to be effective in cancer therapy in preclinical and clinical studies. Importantly, tumor-specific alterations such as ATM loss and Cyclin E1 (CCNE1) amplification are more sensitive to ATR inhibition and are being exploited in synthetic lethality (SL) strategy. Besides SL, synergistic anticancer effects involving ATRi have been reported in an increasing number in recent years. This review focuses on the recent advances in different forms of synergistic antitumor effects, summarizes the pharmacological benefits and ongoing clinical trials behind the biological mechanism, and provides perspectives for future challenges and opportunities. The hope is to draw awareness to the community that targeting ATR should have great potential in developing effective anticancer medicines.     

三类有向三元系之间关系的一种猜想

一个Mendelsohn (Directed, 或Hybrid)三元系 MTS$(v, \lambda)$~(DTS$(v, \lambda)$,或HTS$(v,\lambda))$, 是由$v$元集$X$ 上的一些循环（可迁,或循环和可迁）三元组(简称区组)构成的集合${\cal B}$, 使得$X$上每个由不同元素组成的有序对都恰在 ${\cal B}$的$\lambda$个区组中出现.本文主要讨论了这三类有向三元系之间的一种关联关系,给出猜想：任意MTS$(v,\lambda)$的区组关联图$G(\     

α-可分解4-圈系统

An m-cycle system of order ν and index λ, denoted by rn-CS(ν, λ), is a collection of cycles of length m whose edges partition the edges of λκ_v. An m-CS(ν, λ) is α-resolvable if its cycles can be partitioned into classes such that each point of the design occurs in precisely α cycles in each class. The necessary conditions for the existence of such a design are m|λν(ν-1)/2,2|λ(ν-1), m|αν,α|λ(ν-1)/2 It is shown in this paper that these conditions are also sufficient when m = 4.     

Design of square-shaped heat flux cloaks and concentrators using method of coordinate transformation

A square-shaped heat flux cloak and a square-shaped heat flux concentrator have been designed theoretically according to the invariance symmetry of steady state thermal conductive equation. The direction of heat flux in these devices can be modulated as desired. Using the method of coordinate transformation, the inhomogeneous and anisotropic thermal conductivity in the transformation region have been acquired. Two-dimensional finite element simulations were performed to confirm the theoretical results.     

二维铁电材料α-In2Se3 表面分子束外延生长Pb 纳米岛的STM 研究

铁电材料拥有自发电极化, 不同的极化方向会对异质结的电子结构产生可逆的和非易失性的影响. 本工作采用分子束外延技术在二维铁电材料α-In2Se3 衬底上成功制备了 Pb 纳米岛构建 Pb/α-In2Se3 超导铁电异质结,并通过扫描隧道显微镜表征了其表面原子结构与电子结构. 进一步的扫描隧道谱测量显示不同层厚 Pb 岛的量子阱态消失, 并且我们在4.5 K 的温度下没有观察到超导能隙, 表明铁电衬底会影响 Pb 岛的电子结构, 甚至其超导特性. 这些发现为理解铁电衬底对超导性的影响提供了参考, 并为调控低维量子材料中的电子结构及超导性提供了新的思路.     

求解Euler方程的区域分解方法与并行算法

将复杂形状区域划分成多块子区域,研究发展了一种多块区域之间迎风守恒型的内边界耦合方法,实现相邻子区域解的光滑过渡,使多区耦合得到总体流场的数值解。对二维翼型跨音速流动和圆弧形隆起物超音速流动等进行了分区数值计算,并将计算结果与单区计算结果和实验结果作了比较。并行分区计算引入"先进先出"的同步控制等待机制,实现了高效率并行计算,还分析了影响并行效率的主要因素。     

A minimization version of a directed subgraph homeomorphism problem

We consider a special case of the directed subgraph homeomorphism or topological minor problem, where the host graph has a specific regular structure. Given an acyclic directed pattern graph, we are looking for a host graph of minimal height which still allows for an embedding. This problem has applications in compiler design for certain coarse-grain reconfigurable architectures. In this application domain, the task is to simultaneously schedule, bind and route a so-called data-flow graph, where vertices represent operations and arcs stand for data dependencies between the operations, given an orthogonal grid structure of reconfigurable processing elements (PEs) that have restricted communication abilities. We show that the problem of simultaneously scheduling, binding and routing is NP-complete by describing a logic engine reduction from NAE-3-SAT. This result holds even when the input graph is a directed tree with maximum indegree two. We also give a |V|^3/2-approximation algorithm. J. A. Brenner’s research supported by the DFG Research Center Matheon “Mathematics for key technologies”. J. C. van der Veen’s research supported by DFG Focus Program 1148, “Reconfigurable Architectures”, Grants FE 407/8-1 and FE 407/8-2.     

The influence of a radical structure on the kinetics of photopolymerization

A radical initiation ability of new initiating systems in photopolymerization of 2‐ethyl‐2‐(hydroxymethyl)‐1,3‐propanediol triacrylate has been investigated and presented. The evaluation of alkyltriphenyl‐ and tetraalkylborates, iodonium salts, N‐alkoxypyridinium salts, maleimides, phthalimides, 1,3,5‐triazine derivatives and others as a free radical source in combination with suitable photosensitizer for radical polymerization of triacrylate is described. It is assumed that the photochemical decomposition of a coinitiator molecule results in formation of free radicals, which further initiate polymerization. The order of activity of free radical sources on kinetic of photopolymerization was also presented. Different initiator activity can be explained by the difference in the decomposition rate constant and the reactivity of radicals formed toward the double bond of monomer. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55, 1575–1589