全文获取类型
收费全文 | 208篇 |
免费 | 1篇 |
国内免费 | 1篇 |
专业分类
化学 | 141篇 |
晶体学 | 2篇 |
力学 | 3篇 |
数学 | 13篇 |
物理学 | 51篇 |
出版年
2020年 | 2篇 |
2019年 | 2篇 |
2016年 | 7篇 |
2014年 | 2篇 |
2013年 | 7篇 |
2012年 | 9篇 |
2011年 | 17篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 16篇 |
2007年 | 8篇 |
2006年 | 11篇 |
2005年 | 13篇 |
2004年 | 7篇 |
2003年 | 7篇 |
2002年 | 4篇 |
2001年 | 5篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 6篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 3篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 3篇 |
1965年 | 2篇 |
1961年 | 1篇 |
1960年 | 3篇 |
1959年 | 3篇 |
1948年 | 2篇 |
1902年 | 1篇 |
排序方式: 共有210条查询结果,搜索用时 0 毫秒
151.
A structural analysis of effective medium formed by dispersed systems from the viewpoint of flux modification at large dispersions
is presented. The effective medium coefficient is investigated for its parametric dependence and the effective properties
are estimated through this dependence. This estimation covers all highly dispersed two-phase systems including the effect
of container. 相似文献
152.
GaAs MIS field effect transistors with a Ge3N4 dielectric gate have been investigated. No hysteresis loop and drain current drift has been observed in theI
D
-V
Dcharacteristics. However, performance of the devices have been found to be limited by the contact resistance. FromI
DS
1/2
-V
G plot, the threshold voltage and effective channel mobility of the transistor have been obtained as -4.5V and 2800cm2v–1s–1, respectively. A maximum dc transconductance of 68 mS/mm of gate width has been achieved. 相似文献
153.
Sukriti Nigam B. S. Jayashree Aditya Narayan Pande N. D. Reddy J. Venkata Rao 《Research on Chemical Intermediates》2018,44(2):901-924
N-Benzyltetrahydropyridinyl-4,6-dimethoxy phenyl-substituted 2′-hydroxychalcones SJC1–15 were synthesized using Claisen–Schmidt condensation, their structures confirmed by spectral analysis, and their anticancer activity evaluated. To support their biological activity, physicochemical parameters such as lipophilicity and oxidation potential were determined. To assess their relative cytotoxicity, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed using MCF-7, T-47D, MDA MB-231, HepG2, and Vero cell lines. The cytotoxicity of the chalcones was found to vary with the nature of the ring B substituents. The lipophilicity of the cytotoxic compounds expressed in terms of distribution coefficient was found to lie in the range of 2.4–4.2. Further evaluation of their antioxidant potential revealed antioxidant activity by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging assay and irreversible electrochemical reaction with oxidation potential in the range of 0.879–1.048 V. Of the 15 chalcones, SJC4, 5, 9 were selected for further in vitro studies using MCF-7. The compounds exhibited significant apoptotic effect and caused cell cycle arrest at G0/G1 and G2/M phase. Among them, two of the O-alkylated chalcones (SJC5, 9) showing promising activity against hormone-responsive breast cancer cells were evaluated for their in vivo anticancer activity using 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor model. Three-week treatment with the test compounds at oral dosage of 100 mg kg?1 per day significantly improved elevated tumor parameters compared with tumor control. Treatment with chalcone SJC5 (a 2,4,5-trimethoxy derivative) exhibited anticancer effects similar to those of doxorubicin (2 mg kg?1 per week, i.p.) and was free from toxic effects observed with doxorubicin treatment. 相似文献
154.
Umesh C. Pande Helge Egsgaard Elfinn Larsen Mikael Begtrup 《Journal of mass spectrometry : JMS》1981,16(9):377-380
A series of pyrazolium bromides were investigated by field desorption, field ionization and electron impact mass spectrometry. Dealkylation was found to be the predominant thermal decomposition. The nature of the substituents controls the pyrazole formed. The application of field ionization was found to facilitate the interpretation of the thermolytic decomposition products. Field ionization and electron impact mass spectra of N-phenylpyrazole and N-benzylpyrazole were obtained. 相似文献
155.
Summary o-Phenylenedioxydiacetic acid has been found to be a selective reagent for the estimation of zirconium. As little as 2.1 mg of zirconium can be easily estimated. The composition of the precipitate varies somewhat and therefore, direct weighing is not possible. This difficulty is overcome by igniting as oxide. Be2+, Ca2+, Ba2+, Zn2+, Hg2+, Al3+, Ce3+, Ti4+, Th4+, UO2+, Mn2+, Fe3+, Co2+, and Ni2+, ions do not interfere. Although V2O2
4+ and Cr3+ ions are not precipitated in neutral or slightly acidic solutions they contaminate the zirconium precipitate, at about 0.30 N HCl concentration. The amount of contamination is so small that it is removed by double precipitation. This method gives satisfactory results even in the presence of small amounts of SO4
2–ions. 相似文献
156.
157.
We propose a novel normal mode multiple time stepping Langevin dynamics integrator called NML. The aim is to approximate the kinetics or thermodynamics of a biomolecule by a reduced model based on a normal mode decomposition of the dynamical space. Our basis set uses the eigenvectors of a mass reweighted Hessian matrix calculated with a biomolecular force field. This particular choice has the advantage of an ordering according to the eigenvalues, which have a physical meaning of being the square of the mode frequency. Low frequency eigenvalues correspond to more collective motions, whereas the highest frequency eigenvalues are the limiting factor for the stability of the integrator. In NML, the higher frequency modes are overdamped and relaxed near their energy minimum while respecting the subspace of low frequency dynamical modes. Our numerical results confirm that both sampling and rates are conserved for an implicitly solvated alanine dipeptide model, with only 30% of the modes propagated, when compared to the full model. For implicitly solvated systems, NML gives a twofold improvement in efficiency over plain Langevin dynamics for sampling a small 22 atom (alanine dipeptide) model and in excess of an order of magnitude for sampling an 882 atom (bovine pancreatic trypsin inhibitor) model, with good scaling with system size subject to the number of modes propagated. NML has been implemented in the open source software PROTOMOL. 相似文献
158.
The mechanism by which the aqueous cosolvents guanidinium chloride and urea denature proteins is a matter of controversy. Here, we use all-atom molecular dynamics simulations to study the effect of both denaturants on the dewetting of water confined between nanoseparated hydrophobic plates. It is found that the denaturants inhibit the onset of dewetting, so that it occurs at shorter interplate distances than in pure water. Our results support a role for urea and guanidinium in assisting in the solvation of nonpolar surfaces, thereby weakening hydrophobic effects known to be important for protein stability. 相似文献
159.
Bowman GR Huang X Yao Y Sun J Carlsson G Guibas LJ Pande VS 《Journal of the American Chemical Society》2008,130(30):9676-9678
Hairpins are a ubiquitous secondary structure motif in RNA molecules. Despite their simple structure, there is some debate over whether they fold in a two-state or multi-state manner. We have studied the folding of a small tetraloop hairpin using a serial version of replica exchange molecular dynamics on a distributed computing environment. On the basis of these simulations, we have identified a number of intermediates that are consistent with experimental results. We also find that folding is not simply the reverse of high-temperature unfolding and suggest that this may be a general feature of biomolecular folding. 相似文献
160.
Yadav M Patel D Singhal P Prasad R Goswami S Shrivastav PS Pande UC 《Rapid communications in mass spectrometry : RCM》2008,22(4):511-518
The effect of nitrogen as the collision-activated dissociation (CAD) gas on the fragmentation of dipyridamole was investigated in the range of 10-90 eV collision energy. The results support the collision model reported elsewhere, that the degree of ion fragmentation increases with the increasing mass of the collision gas. A simple, sensitive and high-throughput liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed for the determination of dipyridamole, a platelet aggregation inhibitor in human plasma, using granisetron as internal standard (IS). The method involved liquid-liquid extraction of the analyte and IS from 0.5 mL human plasma with diethyl ether. The chromatographic separation was achieved under isocratic conditions and the ion transitions for dipyridamole (m/z 505.40 --> 429.60) and the IS (m/z 313.10 --> 138.20) were monitored on a triple quadrupole mass spectrometer, operating in positive ion multiple reaction monitoring (MRM) mode. The method was validated over the concentration range 5.1-4499.1 ng/mL for dipyridamole. The method was rugged and rapid with a total run time of 1.2 min. It was successfully applied to a pivotal bioequivalence study in 67 healthy human subjects after oral administration of a 75 mg extended release formulation under fasting condition. 相似文献