Theoretical Evaluation of the Global and Local Electrophilicity Patterns to Characterize Hetero Diels-Alder Cycloaddition in the Synthesis of Isoxazolo[4,5-e](1,2,3,4-tetrazine)

A series of substituted dienophiles 1—10 and three 1,2-diazadienes namely D-1, D-2, D-3 were chosen to understand the reactivity and selectivity of Diels-Alder cycloaddition. The global and local electrophilicity patterns have been evaluated on a series of cycloaddition reactions to assess the reaction pathways (NDAC/IEDDAC) using the absolute scale of electrophilicity proposed by Parr et al. Regional electrophilicity at the active sites of the reagents involved in Diels-Alder processes has been described on a quantitative basis using local or regional electrophilicity index i.e. Fukui function. Good qualitative/quantitative comparison was found between molecular energy gaps and global electronic parameters, which has been employed to assess the cycloaddition pathways successfully.     

PHOTODYNAMIC ACTION OF MEROCYANINE 540 IN ARTIFICIAL BILAYERS AND NATURAL MEMBRANES: ACTION SPECTRA AND QUANTUM YIELDS

The action spectra and quantum yields for singlet oxygen (1O2) generation by merocyanine 540 (MC540) in liposomes and isolated erythrocyte membranes were obtained using electron spin resonance techniques. Oxygen consumption was measured by spin label oximetry in the presence of histidine for fully-saturated dimyristoylphosphatidylcholine vesicles, mono-unsaturated 1-palmitoyl-2-oleoylphosphatidylcholine vesicles and erythrocyte membranes. The quantum yield for the photogeneration of 1O2 by membrane-bound MC540 in aqueous buffer was determined to be 0.065 +/- 0.005, which is approx. 1/10 of the value determined for Rose Bengal under similar conditions. Using unilamellar liposomes and isolated erythrocyte membranes containing MC540 at different monomer/dimer ratios, we have observed that the action spectra of 1O2 generation closely overlap the absorption spectra of the monomeric dye in these systems. It is likely that factors which affect the monomer-dimer equilibrium of MC540 will influence the production of 1O2. These findings have important implications for the phototherapeutic efficacy of MC540.     

Linearly polarized intracavity passive Q-switched Yb-doped photonic crystal fibre laser

In this paper we report linearly polarized high average power passive Q-switched ytterbium-doped photonic crystal fibre laser with a Cr⁴⁺:YAG crystal as a saturable absorber. An average output power of 9.4 W with pulse duration of 64 ns and pulse repetition rate of 57.4 kHz with a slope efficiency of 52% was achieved. Measured polarization extinction ratio (PER) of the Q-switched laser output was 10.5 dB.     

Coherent oscillations of holes in GaAs0.86P0.14/Al0.7Ga0.3As surface quantum well

We show that in a GaAs_0.86P_0.14/Al_0.7Ga_0.3As near-surface quantum well, there is coherent oscillation of holes observed in time-resolved reflectivity signal when the top barrier of the quantum well is sufficiently thin. The quantum well states interact with the surface states under the influence of the surface electric field. The time period of the observed oscillation is 120±10 fs.     

Performance of Dispersion-Compensated Optical Transmission Systems Based on Different Electrical Drivers

In this article, the simulation results have been presented for dispersive optical communication with different electrical drivers. The length of single-mode fiber has been put in a run that is compensated by dispersion-compensated fiber. The results have been presented and it is observed that of all the electrical drivers, the NRZ rectangular is best suited for dispersive optical communication systems. For this electrical driver, the parameters like BER remain constant and low. For other drivers, the BER decreases more for RZ super-Gaussian. Similarly, the Q factor increases with runs for all types of drivers except for NRZ rectangular, for which it decreases. For all the drivers, it is clear that as the runs are varied, the eye opening penalty increases, that is, there is less eye opening as the length of single-mode fiber is increased. It is also seen that the dispersion-compensated fiber compensates for the dispersion very effectively irrespective of the type of driver. Of the two formats, return to zero (RZ) and non-return to zero (NRZ), the earlier has more eye-opening penalty as the distortion is more and is clearly visible in all the rectangular, super-Gaussian, and raised cosine RZ formats. Of the three RZ formats, it is observed that RZ rectangular has the least eye-opening penalty. The non-return to zero format has less distortion and, of the two rectangular and raised cosine, the NRZ rectangular has less eye-opening penalty.     

Systematic study of multiparticle production in nucleus–nucleus interactions at 14.6 A GeV

An experimental analysis of 855 events induced by 14.6 A GeV ²⁸Si in nuclear emulsion is presented. Mean multiplicities of charged secondary particles produced in the nuclear interactions are studied and compared with the results from the other experiments for the same projectile at 3.7 A GeV as well as data for proton at similar energy (14 GeV). An analysis of pseudorapidity densities of target fragments (black and grey particles) is also performed. The behaviour of the KNO scaling law of the multiplicity distribution for shower particles has been examined. In order to accumulate knowledge about the intermittent behaviour of shower particles, the scaled factorial moments (SFMs) are computed in η-space and ?-space for a set of data in the ²⁸Si–AgBr events. Furthermore, validity of limiting fragmentation of shower particles produced in central collision events induced by ²⁸Si-emulsion interactions has been tested. A crude estimation for the energy density of the nuclear matter formed in the central collision events at our energy has been examined.     

Beam lifetime measurement and analysis in Indus-2 electron storage ring

In this paper, the beam lifetime measurement and its theoretical analysis are presented using measured vacuum pressure and applied radio frequency (RF) cavity voltage in Indus-2 electron storage ring at 2 GeV beam energy. Experimental studies of the effect of RF cavity voltage and bunched beam filling pattern on beam lifetime are also presented. An equation of stable beam current decay is evolved and this equation closely follows the observed beam current decay pattern. It shows that the beam is stable and the beam current decay is due to the beam–residual gas interaction (vacuum lifetime) and electron–electron interaction within a bunch (Touschek lifetime). The estimated vacuum, Touschek and total beam lifetimes from analytical formulations are also compared with the measured beam lifetime.     

Temporal dynamics of high repetition rate pulsed single longitudinal mode dye laser

Theoretical and experimental studies of temporal dynamics of grazing incidence grating (GIG) cavity, single-mode dye laser pumped by high repetition rate copper vapour laser (CVL) are presented. Spectral chirp of the dye laser as they evolve in the cavity due to transient phase dynamics of the amplifier gain medium is studied. Effect of grating efficiency, focal spot size, pump power and other cavity parameters on the temporal behaviour of narrow band dye laser such as build-up time, pulse shape and pulse width is studied using the four level dye laser rate equation and photon evolution equation. These results are compared with experimental observations of GIG single-mode dye laser cavity. The effect of pulse stretching of CVL pump pulse on the temporal dynamics of the dye laser is studied.     

Comparison of spectrum normalization techniques for univariate analysis of stainless steel by laser-induced breakdown spectroscopy

Analytical performance of six different spectrum normalization techniques, namely internal normalization, normalization with total light, normalization with background along with their three-point smoothing methods were studied using LIBS for quantification of Cr, Mn and Ni in stainless steel. Optimization of the number of laser shots per spectrum was carried out to obtain the best analytical results. Internal normalization technique model was used for selecting the best emission lines having sufficient intensity and spectral purity for Cr, Mn and Ni for comparison of different normalization techniques. For detailed evaluation of these normalization techniques, under optimized experimental conditions, three statistical parameters i.e., standard error of prediction, relative standard deviation and average bias, were compared for these techniques using the selected emission lines. Results show that the internal normalization technique produces the best analytical results followed by total light normalization. The smoothing of the raw spectra reduces the random error and produces better analytical results provided the peak under study has sufficient (≥7) number of pixels.