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31.
H. Gerlach 《Optics Communications》1974,12(4):405-408
A report is given on difference frequency generation in LiIo3 within a spectral range from 1.5 μ through 4.8 μ using two flashlamp-pumped tunable dye lasers. A novel phase matching geometry having parallel Poynting vectors inside the crystal was experimentally tested. 相似文献
32.
G.?SuchaneckEmail author M.?Guenther J.?Sorber G.?Gerlach K.-F.?Arndt B.?Wolf 《Applied Physics A: Materials Science & Processing》2004,78(5):695-698
In this work, a complex investigation of the film surface composition and nanoscale mechanical properties, i.e. hardness and elastic modulus, of plasma-modified and silica-coated hydrogel thin films was carried out. Plasma treatment was performed in a reactive ion etching chamber (SF6, CHF3) at radio frequency (rf, 13.56 MHz) and in a plasma-enhanced chemical vapor deposition chamber (SiH4/N2, NH3, N2O) at radio frequency and dual frequency (13.56 MHz/100 kHz), respectively. The use of the dual-frequency configuration comprising two power supplies and operated in a switched mode enabled the investigation of the ion-bombardment influence on the polymer properties. For the application in silicon micromachined sensors best results were obtained by using a NH3 or SiH4/N2 low-pressure plasma modification and a silica coating of the sensitive hydrogel film. PACS 81.05.Lg; 81.15.Gh; 81.65.Cf; 81.70.Bt 相似文献
33.
Tengel T Fex T Emtenas H Almqvist F Sethson I Kihlberg J 《Organic & biomolecular chemistry》2004,2(5):725-731
Identification of compounds from chemical libraries that bind to macromolecules by use of NMR spectroscopy has gained increasing importance during recent years. A simple methodology based on (19)F NMR spectroscopy for the screening of ligands that bind to proteins, which also provides qualitative information about relative binding strengths and the presence of multiple binding sites, is presented here. A library of fluorinated compounds was assembled and investigated for binding to the two bacterial chaperones PapD and FimC, and also to human serum albumin (HSA). It was found that library members which are bound to a target protein could be identified directly from line broadening and/or induced chemical shifts in a single, one-dimensional (19)F NMR spectrum. The results obtained for binding to PapD using (19)F NMR spectroscopy agreed well with independent studies based on surface plasmon resonance, providing support for the versatility and accuracy of the technique. When the library was titrated to a solution of PapD chemical shift and linewidth changes were observed with increasing ligand concentration, which indicated the presence of several binding sites on PapD and enabled the assessment of relative binding strengths for the different ligands. Screening by (19)F NMR spectroscopy should thus be a valuable addition to existing NMR techniques for evaluation of chemical libraries in bioorganic and medicinal chemistry. 相似文献
34.
Protein adsorption onto silica nanoparticles: conformational changes depend on the particles' curvature and the protein stability 总被引:6,自引:0,他引:6
Lundqvist M Sethson I Jonsson BH 《Langmuir : the ACS journal of surfaces and colloids》2004,20(24):10639-10647
We have analyzed the adsorption of protein to the surfaces of silica nanoparticles with diameters of 6, 9, and 15 nm. The effects upon adsorption on variants of human carbonic anhydrase with differing conformational stabilities have been monitored using methods that give complementary information, i.e., circular dichroism (CD), nuclear magnetic resonance (NMR), analytical ultracentrifugation (AUC), and gel permeation chromatography. Human carbonic anhydrase I (HCAI), which is the most stable of the protein variants, establishes a dynamic equilibrium between bound and unbound protein following mixture with silica particles. Gel permeation and AUC experiments indicate that the residence time of HCAI is on the order of approximately 10 min and slowly increases with time, which allows us to study the effects of the interaction with the solid surface on the protein structure in more detail than would be possible for a process with faster kinetics. The effects on the protein conformation from the interaction have been characterized using CD and NMR measurements. This study shows that differences in particle curvature strongly influence the amount of the protein's secondary structure that is perturbed. Particles with a longer diameter allow formation of larger particle-protein interaction surfaces and cause larger perturbations of the protein's secondary structure upon interaction. In contrast, the effects on the tertiary structure seem to be independent of the particles' curvature. 相似文献
35.
Structural isomers of [UO(2)(oxalate)(3)](4-), [UO(2)(oxalate)F(3)](3-), [UO(2)(oxalate)(2)F](3-), and [UO(2)(oxalate)(2)(H(2)O)](2-) have been studied by using EXAFS and quantum chemical ab initio methods. Theoretical structures and their relative energies were determined in the gas phase and in water using the CPCM model. The most stable isomers according to the quantum chemical calculations have geometries consistent with the EXAFS data, and the difference between measured and calculated bond distances is generally less than 0.05 A. The complex [UO(2)(oxalate)(3)](4-) contains two oxalate ligands forming five-membered chelate rings, while the third is bonded end-on to a single carboxylate oxygen. The most stable isomer of the other two complexes also contains the same type of chelate-bonded oxalate ligands. The activation energy for ring opening in [UO(2)(oxalate)F(3)](3-), deltaU++ = 63 kJ/mol, is in fair agreement with the experimental activation enthalpy, deltaH++ = 45 +/- 5 kJ/mol, for different [UO(2)(picolinate)F(3)](2-) complexes, indicating similar ring-opening mechanisms. No direct experimental information is available on intramolecular exchange in [UO(3)(oxalate)(3)](4-). The theoretical results indicate that it takes place via the tris-chelated intermediate with an activation energy of deltaU++ = 38 kJ/mol; the other pathways involve multiple steps and have much higher activation energies. The geometries and energies of dioxouranium(VI) complexes in the gas phase and solvent models differ slightly, with differences in bond distance and energy of typically less than 0.06 A and 10 kJ/mol, respectively. However, there might be a significant difference in the distance between uranium and the leaving/entering group in the transition state, resulting in a systematic error when the gas-phase geometry is used to estimate the activation energy in solution. This systematic error is about 10 kJ/mol and tends to cancel when comparing different pathways. 相似文献
36.
R. Jung S. Gerlach R. Schumann G. von Oppen U. Eichmann 《The European Physical Journal D - Atomic, Molecular, Optical and Plasma Physics》2003,23(3):415-419
We report on the first successful loading of a magneto-optical trap (MOT) with metastable He atoms from a Stark-slower. Thereby,
deceleration of the atoms relies on laser-atom interaction in an inhomogeneous electric field. We show that the results obtained
are comparable with early results from other groups achieved with a Zeeman slower. The Stark slower, which is able to fully
control the final velocity of the atomic He beam, is the first step in achieving complete spin independent kinematic control
based solely on electric fields.
Received 2 October 2002 / Received in final form 20 January 2003 Published online 29 April 2003
RID="a"
ID="a"e-mail: eichmann@mbi-berlin.de 相似文献
37.
G. Tomar D. Gerlach G. Biswas N. Alleborn A. Sharma F. Durst S.W.J. Welch A. Delgado 《Journal of computational physics》2007,227(2):1267-1285
A numerical methodology to simulate two-phase electrohydrodynamic flows under the volume-of-fluid paradigm is proposed. The electric force in such systems acts only at the interface and is zero elsewhere in the two fluids. Continuum surface force representations are derived for the electric field force in a system of dielectric–dielectric and conducting–conducting fluids. On the basis of analytical calculations for simple flow problems we propose a weighted harmonic mean interpolation scheme to smoothen the electric properties in the diffused transition region (interface). It is shown that a wrong choice of interpolation scheme (weighted arithmetic mean) may lead to a transition region thickness dependent electric field in the bulk. We simulate a set of problems with exact or approximate analytical solutions to validate the numerical model proposed. A coupled level set and volume-of-fluid (CLSVOF) algorithm has been used for simulations presented here. 相似文献
38.
This paper examines the extent to which financial returns on market indices exhibit mean and volatility asymmetries, as a response to past information from both the U.S. market and the local market itself. In particular, we wish to assess the asymmetric effect of a combination of local and U.S. market news on volatility. To the best of the authors knowledge, this joint effect has not been considered previously. We propose a double threshold non‐linear heteroscedastic model, combined with a GJR‐GARCH effect in the conditional volatility equation, to capture jointly both mean and volatility asymmetric behaviours and the interactive effect of U.S. and local market news. In an application to five major international market indices, clear evidence of threshold non‐linearity is discovered, supporting the hypothesis of an uneven mean‐reverting pattern and volatility asymmetry, both in reaction to U.S. market news and news from the local market itself. Significant, but somewhat different, interactive effects between local and U.S. news are observed in all markets. An asymmetric pattern in the exogenous relationship between the local market and the U.S. market is also found. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
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