Flow dynamics analyses of pathophysiological liver lobules using porous media theory

Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the liver lobule, is difficult to determine experimentally in humans due to its complicated structure, with radially branched microvas-culature and the technical difficulties that derive from its geometric constraints. Here we established a set of 3D com-putational models for a liver lobule using porous media theory and analyzed its flow dynamics in normal, fibrotic, and cirrhotic lobules. Our simulations indicated that those approximations of ordinary flow in portal tracts (PTs) and the central vein, and of porous media flow in the sinusoidal network, were reasonable only for normal or fibrotic lobules. Models modified with high resistance in PTs and collateral vessels inside sinusoids were able to describe the flow fea-tures in cirrhotic lobules. Pressures, average velocities, and volume flow rates were profiled and the predictions compared well with experimental data. This study furthered our under-standing of the flow dynamics features of liver lobules and the differences among normal, fibrotic, and cirrhotic lobules.     

激光烧蚀铝靶生成空气等离子体的机理

由Ｑ－开关Ｎｄ：ＹＡＧ激光器产生的１．０６μｍ、１０ｎｓ的脉冲激光辐射大气中的铝靶所产生的等离子体发射光谱的研究结果。当作用在铝靶表面的功率密度在１．０×１０￣９Ｗ／ｃｍ￣２－１．４×１０￣（１０）Ｗ／ｃｍ￣２范围时，测定了等离子体在２００至８８０ｎｍ波长范围内的空间、时间分辨发射光谱。实验发现，等离子体中Ｎ￣＋离子的辐射谱线与连续辐射同时出现并一起消失，随激光强度的增加Ｎ￣＋离子密度以指数关系增加，在激光源方向Ｎ￣＋离子的运动速度为零。从靶表面逸出的热电子与氮原子碰撞及随后发生的级联电离过程是产生Ｎ￣＋离子和空气等离子体的原因。     

Bis(pyrazolyl)(thioimidazolyl)borate ligands: the missing member in the N3...S3 scorpionate series

The anionic bis(pyrazolyl)(thioimidazolyl)borate ligands BpMt(R) with R = tert-butyl and isopropyl were obtained as their potassium salts by reacting potassium tris(pyrazolyl)borate with the corresponding thioimidazoles in the melt at 150 degrees C. They were applied to form some tetrahedral zinc complexes and identified by the crystal structures of (BpMt(t-Bu))ZnCl and (BpMt(i-Pr))Zn-SC(6)H(4)-p-Cl.     

Armatans A and B,New Antimicrobial Isoflavans from Colutea armata

Chemistry of Natural Compounds - Armatans A (1) and B (2), new isoflavans, have been isolated from the EtOAc-soluble fraction of the MeOH extract of Colutea armata Hemsl. & Lace, along with...     

Recognition and detection of oligonucleotides in the presence of chromosomal DNA based on entrapment within conducting-polymer networks

Overlapping voltammetric signals, accrued from redox processes of nucleobases, do not permit discrimination between short oligonucleotides and chromosomal DNA molecules when conventional electrochemical techniques are used. This article describes a new genoelectronic route for discriminating between short oligonucleotides and chromosomal DNA, based on the polypyrrole (PPy) doping process. Such a route relies on the profound effect of short nucleic acid dopants upon the redox activity of PPy, and hence on the square-wave voltammetric signal of the polymer-modified electrode in a blank electrolyte solution. The electropolymeric growth of PPy thus serves for preferential accumulation (by doping) of short oligonucleotides. High selectivity is demonstrated for voltammetric measurements of oligo(dG)₂₀ and oligo(dT)₂₀ in the presence of otherwise interfering ss- and ds-DNA. The signals for the oligonucleotides are also not affected by a large excess of chloride or phosphate ions. The response of the new preconcentration (doping)–medium-exchange–voltammetric protocol is proportional to the concentration of the oligonucleotide dopant. Such a new recognition process, based on the doping of conducting-polymer networks, enhances the scope of electroanalysis of nucleic acids.     

n次单位根在代数问题中的应用

主要论述n次单位根在一些组合数求和、多项式的整除、因式分解中的应用,说明了n次单位根法可拓宽解题思路,是一种方便、快捷的数学解题方法.     

β-淀粉样肽的结构、合成与性质及其与老年痴呆症的关系

β－淀粉样肽是β－淀粉样前体蛋白的剪切产物，分别由39－43个氨基酸残基组成。本文介绍了β－淀粉样肽的化学结构、化学合成及β－淀粉样肽与老年痴呆症的关系。     

Three New Monoterpene Alkaloids and a New Caffeic Acid Ester from Incarvillea mairei var. multifoliolata

Three new monoterpene alkaloids, mairine A ( 1 ), mairine B ( 2 ), and mairine C ( 3 ), and a new caffeic acid ester, 2‐(1‐hydroxy‐4,4‐dimethoxycyclohexyl)ethyl caffeate ( 4 ), were isolated from the EtOH extract of the whole plants of Incarvillea mairei var. multifoliolata. The structures of these compounds were established on the basis of 1D‐ and 2D‐NMR and HR‐ESI‐MS analysis.     

Separation and identification of three epimeric pairs of new C-glucosyl anthrones from Rumex dentatus by on-line high performance liquid chromatography–circular dichroism analysis

Six C-glucosyl anthrones were characterized as three pairs of epimers by on-line high performance liquid chromatography–circular dichroism (HPLC–CD) analysis and isolated from the roots of Rumex dentatus by column chromatography. Their structures were elucidated by mass spectrometry, nuclear magnetic spectroscopy and HPLC–CD analysis. They are 10R-C-β-d-glucosyl-10-hydroxyemodin-9-anthrone (rumejaposide E, 1) and 10S-C-β-d-glucosyl-10-hydroxyemodin-9-anthrone (rumejaposide F, 2), 10R-C-β-d-glucosylemodin-9-anthrone (rumejaposide G, 3) and 10S-C-β-d-glucosylemodin-9-anthrone (rumejaposide H, 4), 10S-C-β-d-glucosyl-10-hydroxychrysophanol-9-anthrone (cassialoin, 5) and 10R-C-β-d-glucosyl-10-hydroxychrysophanol-9-anthrone (rumejaposide I, 6). Rumejaposides F–I (2–4 and 6) were new C-glucosyl anthrones. Rumejaposide E (1) and cassialoin (5) were isolated for the first time in Rumex plants. On-line HPLC–UV–CD analysis was a useful tool for structure elucidating epimeric C-glycosides anthrones 3–6 because of the poor stability of the pure isomers (3 and 4) and the minute quantity of 5 and 6 in the mixture.     

SIMULATION OF TYPHOON’S ANOMALOUS TRACK (Ⅰ)──RANKINE VORTEX MODEL

This paper proposes a method for simualting symmetric and simulating symmetric and asymmetric typhoonby using Rankine vortex model. Considering similarity between tropical cyclone andthe Rankine vortex,the paper has qualitatively discussed the feasibility of the methods In order to decide quantitatively Rankine vortex’s parameters to simulate typhoon’s structure, the paper has dealt with TCM data.for Yancy Typhoon (9012) as initial fields.. These results are considered as a foundation for further studying typhoon motion by CD approach.