An intramolecular nucleophilic substitution of oxetanes

The intramolecular attack of carbanions to oxetanes were examined and several three, five, and six membered carbocyclic compounds were synthesized.     

Tunneling time based on the quantum diffusion process approach in multichannel and optical potential cases

We analyze the effects of inelastic scattering on the tunneling time theoretically, using generalized Nelson’s quantum mechanics. This generalization enables us to describe quantum system with channel couplings and optical potential in a real time stochastic approach, which seems to give us a new insight into quantum mechanics beyond Copenhagen interpretation     

Synthesis and evaluation of 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic acid ethyl ester derivatives as potent antitumor agents

For the construction of new combinatorial libraries, a lead compound was created by replacing the core structure of a hit compound discovered by screening for cytotoxic agents against a tumorigenic cell line. The newly designed compound maintained biological activity and allowed alternative library construction for antitumor drugs.