全文获取类型
收费全文 | 4037篇 |
免费 | 556篇 |
国内免费 | 397篇 |
专业分类
化学 | 2856篇 |
晶体学 | 33篇 |
力学 | 178篇 |
综合类 | 45篇 |
数学 | 594篇 |
物理学 | 1284篇 |
出版年
2024年 | 12篇 |
2023年 | 77篇 |
2022年 | 134篇 |
2021年 | 131篇 |
2020年 | 145篇 |
2019年 | 157篇 |
2018年 | 152篇 |
2017年 | 125篇 |
2016年 | 197篇 |
2015年 | 184篇 |
2014年 | 259篇 |
2013年 | 294篇 |
2012年 | 331篇 |
2011年 | 315篇 |
2010年 | 231篇 |
2009年 | 214篇 |
2008年 | 256篇 |
2007年 | 208篇 |
2006年 | 205篇 |
2005年 | 168篇 |
2004年 | 140篇 |
2003年 | 122篇 |
2002年 | 145篇 |
2001年 | 125篇 |
2000年 | 71篇 |
1999年 | 68篇 |
1998年 | 61篇 |
1997年 | 41篇 |
1996年 | 38篇 |
1995年 | 43篇 |
1994年 | 48篇 |
1993年 | 35篇 |
1992年 | 34篇 |
1991年 | 41篇 |
1990年 | 30篇 |
1989年 | 16篇 |
1988年 | 15篇 |
1987年 | 14篇 |
1986年 | 9篇 |
1985年 | 16篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 6篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1971年 | 5篇 |
1962年 | 3篇 |
排序方式: 共有4990条查询结果,搜索用时 15 毫秒
61.
The vapor‐phase reaction of citronellal (CTN) at 220 °C and atmospheric pressure has been studied using mesoporous molecular sieves and zeolites in a fixed‐bed reactor. The primary products included isopulegol (IPG), menthone, and pulegol with subsequent reactions to form cyclic hydrocarbons. The CTN conversion and the product selectivity depend on the acidity and the textural property of catalysts. Lewis and/or Brönsted acid sites are essential for catalyzing this reaction. An increase of SiO2/Al2O3 mol ratio diminishes the acid amount of all catalysts and enhances both the surface area and the structural order of MCM‐41. The catalytic activity follows the order of MCM‐41 > HZSM‐5 > Hβ > USY, in accordance with the relative total acid amount except that of MCM‐41. Despite its low acidity, Si‐MCM‐41 exhibits the best catalytic performance due to its uniform mesopores, large surface area and good stability; the CTN conversion and the IPG yield attain 91.9% and 58.6%, respectively, after at least 25 h time‐on‐stream. 相似文献
62.
63.
64.
Xiaobin Wang Xincan Fu Min Chen An Wang Jinghua Yan Yudong Mei Mengqi Wang Chunlong Yang 《中国化学快报》2019,30(7):1419-1422
A series of novel 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety were designed, synthesized and evaluated for their biological activities against phytopathogenic fungi. The antifungal bioassays indicated that the title compound 5b impressively displayed the obvious selectivity and specificity aganist Rhizoctonia solani (Rs) in vitro and in vivo. The above researches provide a significant reference for the further structural optimization of 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety as potential fungicides. 相似文献
65.
Min Gyu Jeong Kai Zhou Soyeon Park HyeongJeon An Yonghoon Kwon Yeonho Chang Do-Hyeon Kim Sung Ho Ryu 《Experimental & molecular medicine》2021,53(2):291
Various repertoires of membrane protein interactions determine cellular responses to diverse environments around cells dynamically in space and time. Current assays, however, have limitations in unraveling these interactions in the physiological states in a living cell due to the lack of capability to probe the transient nature of these interactions on the crowded membrane. Here, we present a simple and robust assay that enables the investigation of transient protein interactions in living cells by using the single-molecule diffusional mobility shift assay (smDIMSA). Utilizing smDIMSA, we uncovered the interaction profile of EGFR with various membrane proteins and demonstrated the promiscuity of these interactions depending on the cancer cell line. The transient interaction profile obtained by smDIMSA will provide critical information to comprehend the crosstalk among various receptors on the plasma membrane.Subject terms: Fluorescence imaging, Super-resolution microscopy, Single-molecule biophysics 相似文献
66.
An efficient and feasible synthetic approach was developed for the synthesis of an array of new flavane derivafives from the substituted benzaldehyde with the reduction of chalcones and subsequent cyclization as the key steps. The purity and structure of the products were confirmed by the elemental analysis and a combination of its IR, ^1H and ^13C NMR, and mass spectra. These synthetic compounds were tested for xanthine oxidase (XO) inhibitions and antifungal actions against Candida albicans, Cryptococcus neoformans, Aspergillus sp. and Trichophyton rubrum. 7-Hydrazinocarbonylmethoxy-4'-methoxyflavane (9) was found to be the most XO inhibitory with IC50=76.4 μmol/L, and the most potent antifungal compound was 4'-hydrazinocarbonylmethoxyflavane (12) with minimal inhibition concentration MIC=8 μg/mL against Trichophyton rubrum. 相似文献
67.
68.
用手性的丙烯酸薄荷醇酯与原位生成的1,3-偶极试剂发生Diels-Alder反应, 得到一系列新的手性2,4-二酯基四氢吡咯衍生物,经氢化铝锂还原得到纯的手性 2,4-二羟甲基吡咯衍生物。并首次发现,在用Oxone氧化烯时,2,4-二羟甲基四 氢吡咯衍生物能有效地诱导烯烃发生环氧化反应,转化率达到定量。 相似文献
69.
70.
Three new hypocrellin derivatives, amino- or amino acid-substituted on the side ring of hypocrellin B (HB), were synthesized by the reactions of HB with 3-methoxypropylamine, 6-aminohexanoic acid and gamma-amino-n-butyric acid, respectively. The structures of these compounds were characterized with proton nuclear magnetic resonance spectra, infrared spectra and mass spectra. The UV-visible absorption spectra, singlet oxygen-generating quantum yield and amphiphilicities of hypocrellin derivatives were measured and compared with HB, the parent compound. These derivatives showed strong absorption in the domain of the phototherapeutic window (600-900 nm) and improved amphiphilicity. HB and the derivatives were preliminarily tested for their photodynamic effects on human oral cavity epithelial carcinoma KB cell line in vitro. Two amino acid-substituted hypocrellins showed phototoxicity to the KB cell line. At an inhibitory dosage of 50% killing only 0.51 mumol L-1 compound 3 (or 0.88 mumol L-1 compound 2) and 0.5 J cm-2 irradiation were required. The hypocrellins exhibited some dark toxicity to the KB cell line. HB and amino acid-substituted hypocrellins showed lower dark toxicity to the KB cell line than amino-substituted hypocrellins in the assessment of cell survival. 相似文献