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21.
Hugo M. Ortner 《Fresenius' Journal of Analytical Chemistry》1992,343(11):825-826
Conclusion Analytical Chemistry, as we have seen, is quite an established science but also a very vivid and young one. Its boundaries have always been and will be at the very frontiers of natural science: we are approaching the detection of single atoms as well as the analysis of matter at the very fringes of our universe. Analytical Chemistry is essential for the development of taylor-made high-tech materials and equally for the evolution of our knowledge about the toxicity of elements and compounds. It needs specialists with a profound insight in certain fields, for methods development or the handling of very complex instrumentation as e.g. a high resolution secondary ion mass spectrometer. But it also needs allrounders with a broad view not only of the capability of Analytical Chemistry as a whole but with an understanding for the complexity of modern social and economic structures. Frequently new ideas, new concepts and progress are forming on the seams between disciplines, on the grain boundaries of scientific fields too often kept strictly separated from each other. Analytical Chemistry is certainly a discipline which is predestinated for scientific communication collaborating with practically all fields of natural science as well as politics and economics.As a branch of natural science it is neutral in its moral value and therefore needs responsible and courageous analysts to use it for the benefit of mankind. 相似文献
22.
The defect rock-salt type materials Zr1?xS, Sc1?xS, and Lu1?xS have been shown to exhibit a complex variety of ordered superstructures. These superstructures are reviewed within the context of Landau's theory of symmetry and phase transitions, and it is concluded that there is a significant similarity in the transitions when they are considered from the point of view of reciprocal space. 相似文献
23.
Summary A model of the mechanism for recognition of the D1 receptor has been developed. Conformational analysis for 10 agonists from diverse chemical families was carried out as a first step toward the characterization of the bioactive form. First, maximum structural overlap of the features common to all ligands allowed a simple identification of the candidate bioactive form for each ligand. At a second level of characterization, steric and electronic properties were computed for all accessible structures to analyze those properties that may modulate receptor recognition. 相似文献
24.
A number of polyfunctionalized cis-bicycio ¦3.3.0¦octanes have been synthesized starting from the tricyclic key intermediate which was obtained by the intramolecular cyclopropanation reaction of the diazo keto ester . Selected stereocontrolled transformations of using nucleophiles and electrophiles have been studied for the preparation of the title compounds. 相似文献
25.
Hugo F. Franzen Mirtha X. Umaña J.R. McCreary R.J. Thorn 《Journal of solid state chemistry》1976,18(4):363-368
The first-row transition-metal monosulfides and alkaline-earth chalcogenides were studied by means of X-ray photoelectron spectroscopy. It is shown that the bonding in the alkaline earth compounds is relatively ionic with XPS evidence for significant charge separation. On the other hand, transition metal sulfides, with the exception of MnS, appear to be principally metallic with little or no charge separation. Values for the inner orbital binding energy shifts are reported for a large number of monochalcogenides. 相似文献
26.
Raymond Zelnik Ema Rabenhorst Akhtar Haider Jürgen Lauterwein Hugo Wyler 《Helvetica chimica acta》1983,66(3):780-788
Dehydration of abiet-8-ene-7β, 13β-diol (ibozol, 1 ) leads to abieta-7,9(11)-dien-13β-ol ( 2 ) which aromatizes slowly to the known abieta-8,11,13-triene ( 3 ). Photosensitized oxygenation of the heteroannular diene 2 yields a mixture from which three compounds were identified; abiet-7-ene-9α, 11α, 13β-triol ( 4 ), abieta-8,11,13-trien-7-one ( 5 ), and abieta-8,11,13-trien-7α-ol ( 6 ). 相似文献
27.
The high sensitivity that can be attained using an enzymatic system and mediated by 4-tert-butylcatechol (4-TBC) has been verified by on-line interfacing of a rotating biosensor and continuous flow/stopped-flow/continuous-flow processing. Horseradish peroxidase, HRP, [EC 1.11.1.7], immobilized on a rotating disk, in presence of hydrogen peroxide catalyzed the oxidation of 4-TBC, whose back electrochemical reduction was detected on glassy carbon electrode surface at −150 mV. Thus, when penicillamine (PA) was added to the solution, these thiol-containing compounds participate in Michael type addition reactions with 4-TBC to form the corresponding thioquinone derivatives, decreasing the peak current obtained proportionally to the increase of its concentration. The highest response for PA was obtained around pH 7. This method could be used to determine PA concentration in the range 0.02-80 μM (r = 0.998). The determination of PA was possible with a limit of detection of 7 nM, in the processing of as many as 50 samples per hour. The HRP-rotating biosensor was successfully applied to the determination of PA in pharmaceutical formulations. 相似文献
28.
The separation of dilute binary mixtures of proteins by salt aided ion-exchange simulated moving bed (SMB) chromatography is optimized with respect to throughput, desorbent consumption and salt consumption. The optimal flow-rate ratios are analytically determined via an adopted "triangle theory". Azeotropic phenomena are included in this procedure. The salt concentrations in the feed and recycled liquid are subsequently determined by numerical optimization. The azeotropic separation of bovine serum albumin and a yeast protein is used to illustrate the procedure. Gradient operation of the SMB is generally preferred over isocratic operation. A feed of azeotropic salt concentration can only be separated in a gradient SMB. Desorbent and salt consumption are always lower in gradient than in isocratic SMB chromatography. 相似文献
29.
Paleari R Ceriotti F Azzario F Maccioni L Galanello R Mosca A 《Bioelectrochemistry (Amsterdam, Netherlands)》2004,62(2):175-179
An immunologically mediated pathway has been largely accepted to be one of the mechanisms involved in the clearance of senescent or prematurely damaged RBC. According to this pathway, RBC removal is mediated by binding of naturally occurring IgG to clustered integral membrane proteins, followed by complement deposition. The validation of an immunoenzymatic method for the detection of RBC-bound autologous IgG is presented. The use of RBC-bound IgG as an index related to red cell age was evaluated by measuring IgG binding in RBC treated with the clustering agent ZnCl2, in density fractionated RBC and in a selected group of patients expected to have an altered RBC life span. The immunoenzymatic method for IgG detection resulted to be reproducible (CV = 3.4%). IgG binding to in vitro clustered RBC was found to be enhanced to a very great extent, about 20 times higher with respect to untreated RBC. A slight but significant increase (about 1.8-fold) in membrane-bound IgG was observed in the highest density fraction of normal RBC, which constituted 1% of the total cells. A significantly greater number of RBC-bound IgG was measured in splenectomized beta-thalassemia intermedia patients and in subjects with secondary decreases in the C3 complement fraction concentration. 相似文献
30.
On the biogenesis of betacyanins. Expaiments with [2-14C]-dopaxanthine Labelled dopaxanthine is prepared from betanin by a double exchange procedure replacing first its cyclodopa part by diethylamine and effecting the second exchange with 2-[14C]-dopa on the purified intermediate ‘DEA-betalain’; the specific activity delivered with the dopa allowed accurate determination of ? in the electronic spectrum of dopaxanthine (λmax 488 nm, ? = 41.800). The C(2)-labelled dopaxanthine is incubated into the fruits of Opuntia bergeriana. The incorporation rates into betanin are found to correspond approximately to those obtained in earlier experiments with labelled dopa alone: Only 1--5% of the label showed up in the cyclodopa moiety of the betanin (which is isolated as cyclodopa-glucoside) whereas 99--95% of the radioactivity was associated with the betalamic acid part (recovered in form of indicaxanthine). 相似文献