Quercetin enhances vitamin D2 stability and mitigate the degradation influenced by elevated temperature and pH value

Vitamin D₂ (vit. D₂) is a nutraceutical essentially needed for good health. However, it is susceptible to oxygen and high temperature. The use of natural products such as bioflavonoids possessing anti-degradative effect of vit. D₂ degradation has not been described before. A combinational effect of vit. D₂ with quercetin showed a positive effect and inhibited vit. D₂ degradation when exposed to high temperature (50 ℃ and 75 ℃) at different time points. The results obtained revealed vit. D₂ degradation was drastically increased with longer incubation under thermal treatment. However, quercetin and vit. D₂ groups were able to significantly inhibit the degradation of vit. D₂ and stabilize it, evaluated through the retention percentage. We also exposed vit. D₂ at solutions with different pH values (1, 4, 5, 7, 10). Quercetin exerted vit. D₂ anti-degradation at different pH values as well as under thermal pressure at different time points. Conclusively, quercetin can be an effective way to reduce temperature and pH induced degradation of vit. D₂.     

Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine

We described a novel approach for survivin siRNA cellular delivery via a cationic liposome incorporating fatty acid-modified polyethylenimine. A linoleic acid derivative of branched polyethylenimine(PEI, M_w=25 kDa), PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. PEI-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently compared with PEI-25kDa.     

锗酸锌锰荧光体发光学与荧光瞬态衰减研究

制备一系列锗酸锌锰荧光体,并探讨其发光特性、瞬态荧光衰减与色度值与所掺杂锰离子含量之间的相互关系.本系列荧光体锰离子发射峰波长,随Mn²⁺含量由0增加0.05,由527nm红移至534nm.实验表明这可能与Mn²⁺所占据的四面体格位,遭扭曲而导致晶场强度变弱有关.本系列荧光体的CIE色度坐标值,则随所掺杂Mn²⁺含量,仅有微小改变.锗酸锌锰荧光体瞬态荧光衰减的研究结果表明:锗酸锌基质的衰减生命期在纳秒范围;随Mn²⁺掺杂量增加,在毫秒范围的锰离子荧光衰减生命期逐渐缩短.此现象可能与Mn²⁺-Mn²⁺离子对中,Mn²⁺的自旋交换相互作用有密切关系.     

Two Novel Copper(Ⅱ) Complexes with A Novel Ligand 2,4-Di(2-aminopyridine)-6-methylpyrimidine

Introduction The design and syntheses of multidentate N-donor ligands have become the focus of much inter-est in the chemical field[1-4]because these ligands can form multinuclear metalxompounds, coordina-tion polymers and supramolecular compounds,which play a very important role in the bilolgicalsystems, magnetic materials,electric materials,optical materials and otherfields[5-8].     

Quantum Secret Sharing Based on Chinese Remainder Theorem

A novel quantum secret sharing (QSS) scheme is proposed on the basis of Chinese Remainder Theorem (CRT). In the scheme, the classical messages are mapped to secret sequences according to CRT equations, and distributed to different receivers by different dimensional superdense-coding respectively. CRT's secret sharing function,together with high-dimensional superdense-coding, provide convenience, security, and large capability quantum channel forsecret distribution and recovering. Analysis shows the security of the scheme.     

壁流动中的转捩

对壁流动的不同实验结果做了对比,这些实验结果来自于流动显示、热膜测量以及PIV测量, 对比的同时,还总结了与此相应的理论方面的进展.这些进展是在对所选大约120篇文献中内容归纳提炼的基础上给出的.尽管实验中所使用的初始扰动条件不同,但所发现的流动结构几乎是完全一样的. 在对壁流动转捩的认识方面,认为下列所观察到的流动结构是最基本最重要的:在边界层和管流中被称为类孤子相干结构(SCS)的三维非线性涡包、$\Lambda$涡、二次涡环和涡环链.近期的实验中发现了这些结构形成和转捩的动力学过程,具体包括以下内容: (1) $\Lambda$ 涡和二次涡环间持续的相互作用过程.该过程决定了涡环链的产生方式, 总是从壁面区域周期性地形成,并进入到边界层的外部区域; (2)高频涡的生成,这是理解转捩和湍流边界层(以及其他流动)发展的关键问题之一.尽管已经提出了一些解释,但是二次涡环的实验发现将对此提供一个特别清晰的解释.(3)在所有湍流猝发中SCS所起的关键作用.这一点被看做是低雷诺数湍流边界层中湍流产生的关键机制.与猝发直接相关联的是低速条带. 基于SCS的动力学过程, 针对壁流动情况,可以比以前更清晰地解释低速条带的形成机制及其与流动结构的关系.在实验中所观察到的SCS和二次涡环,不仅能使我们重温壁面流动转捩中的经典故事, 同时还开辟一条新的途径,可以基于此建立壁面流动转捩可能具有的普适性的动力学过程.      

平衡问题变分包含问题及不动点问题的二次极小化

借助预解式技巧,寻求二次极小化问题minx∈Ω‖x‖2的解,其中Ω是Hilbert空间中某一广义平衡问题的解集,与一无穷族非扩张映像的公共不动点的集合,以及某一变分包含的解集的交集．在适当的条件下,逼近上述极小化问题的解的一新的强收敛定理被证明．     

基于熵条件二阶差分格式的嵌套网格分区算法

以带熵条件的二阶TVD格式为基本格式,设计了三维曲线坐标下的Euler方程数值计算方法.对多个物体使用分区嵌套网格设计了相应的分区算法.所建立的算法适用于处理物体相互分离以及相互接触的定常与非定常流动问题.给出了绕两圆柱的超声速流动在两圆柱处于不同位置时的详细结果,并模拟了装配鸭舵火箭弹在超声速旋转飞行时的气动特性.     

Synthetic Studies on Halichlorine and Pinnaic Acid. Stereospecific Preparation of the Azaspiro Core Structure

Halichlorine and Pinnaic acid are two novel marine natural products isolated from a Japanese sponge, and an Okinawan bivalve respectively. The unique azaspirl[4.5]decane-core structure prexent in both compounds provides a synthetic challenge, Herein, we describe a synthetic approach to the azaspiro[4.5]decane-core structure through an intramolecular[3+2] cycloaddition followed by an intra-molecular Michael addition and in situ isomerization to afford the azaspirocyclic core structures stereospecifically in 10 steps with 40% overall yield. Alternatively, the same core structure was achieved by tandem cycloaddition and isomerization approach.     

THE EFFECTS OF ITQ IMPLEMENTATION: A DYNAMIC APPROACH

ABSTRACT. This paper investigates the intertemporal effects of introducing Individual Transferable Quota, ITQ, fishery management programs on stock size, fleet size and composition, and returns to quota holders and to vessel operators. Theoretical analysis is conducted using a specific version of a general dynamic model of a regulated fishery. It is demonstrated that the effects will differ depending upon the prevailing regulation program, current stock size, and existing fleet size, composition and mobility and upon how the stock and fleet change over time after the switch to ITQs. The paper expands upon previous works by modeling the dynamics of change in fleet and stock size and by allowing for changes in the TAC as stock size changes, by comparing ITQs to different regulations, and by allowing the status quo before ITQ implementation to be something other than a bioeconomic equilibrium. Specific cases are analyzed using a simulation model. The analysis shows that the annual return per unit harvest to quota owners can increase or decrease over the transition period due to counteracting effects of changes in stock and fleet size. With ITQs denominated as a percentage of the TAC, the current annual value of a quota share depends upon the annual return per unit of harvest and the annual amount of harvest rights. Because the per unit value can increase or decrease over time, it is also possible that the total value can do the same. Distribution effects are also studied and it is shown that while the gains from quota share received are the present value of a potentially infinite stream of returns, potential losses are the present value of a finite stream, the length of which depends upon the remaining life of the vessel and the expected time it will continue to operate.