Methylphosphonothionates of N-(β-hydroxypropyl)anabasine — Synthesis,structure, and sensitivity of cholinesterases to them

The synthesis has been effected of alkyl anabasinoprop-2-yl and alkyl piperidinoprop-2-yl methylphosphonothionates. It has been shown by¹H,¹³C and³¹P NMR spectroscopies that the anabasine derivatives exist in solution as four diastereomeric forms. The kinetics of the interaction of the compounds synthesized with two types of cholinesterases has been studied.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Fax 627071. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 70–74, January–February, 1994.     

Dynamic study of gated saturable absorbers

The capability of gated saturable absorbers for single-pulse selection is studied theoretically using the classical space-time-dependent rate-equation model. The dynamics of operation is followed experimentally by the well-known pump—probe technique. Comparing the theoretical and experimental results, it is found that gated saturable absorbers can efficiently be used for pulse forming and pulse selection of pulses longer than picosecond.     

Recursive partition and amalgamation with the exponential family: Theory and applications

The theory of tree-growing (RECPAM approach) is developed for outcome variables which are distributed as the canonical exponential family. The general RECPAM approach (consisting of three steps: recursive partition, pruning and amalgamation), is reviewed. This is seen as constructing a partition with maximal information content about a parameter to be predicted, followed by simplification by the elimination of ‘negligible’ information. The measure of information is defined for an exponential family outcome as a deviance difference, and appropriate modifications of pruning and amalgamation rules are discussed. It is further shown how the proposed approach makes it possible to develop tree-growing for situations usually treated by generalized linear models (GLIM). In particular, Poisson and logistic regression can be tree-structured. Moreover, censored survival data can be treated, as in GLIM, by observing a formal equivalence of the likelihood under random censoring and an appropriate Poisson model. Three examples are given of application to Poisson, binary and censored survival data.     

On conditions ensuring the highest difference in the association degrees of the equilibrium H and D steams: Clustering and isotope enrichment

A search for conditions leading to the highest possible difference between equilibrium association (clustering) degree in the H and D steam has been carried out and related optimal steam pressures evaluated. The difference decreases with increasing temperature but still is a few per cent at moderate temperatures.     

关于(?)-拟微分核的连续性

Supposa that f(x) is a quasidifferentiable function, defined on S(?)R~n where S is an open set, with a -equivalent bounded quasidifferential subfam ily. Lenma I     

A STUDY OF VARIOUS BARRIERS IN ENCLOSED SOUND FIELD BY USING THE COMPUTER PROGRAM—SOFIS

In the study of the behaviors of barriers in an enclosed field, one should take into account such phenomena as sound energy reflection, absorption, scattering and diffraction. Therefore, the study is much more difficult than that in free field. In this paper, sound barriers are classified into four kinds according to their size, number and shape. Each kind of barriers is modelled by a corresponding method based on a computer program—SOFIS. The program combines the ray-tracing technique and statistical method. The impulse response and some acoustical parameters such as sound pressure level at different positions can be calculated by the program, no matter there are a certain kind of barriers in the field or the field is empty. The ray-tracing program and the algorithms for various barriers are validated by the comparison between measurement and prediction of the reverberation room and the anechoic room of the Northwestern Polytechnic University.