Polyglycerol nanogels (nPG) have a huge impact in biomedical applications as drug deliverer due to their high biocompability. For such nPG nanogels, particle degradation is widely used as drug delivery method. The knowledge of this degradation process is limited up to date. In this communication, a real time visualization of such a degradation process is presented for pH‐responsive nPG nanogels via atomic force microscopy (AFM) under ambient and in liquid conditions. The particle height plays a major role in the degradation process and decays exponentially in the beginning of this process. The particle width increases during the process indicating a “decross‐linking” step of the particles into their starting monomers. Measurements under ambient conditions confirm this assumption and provide further insight in the “decross‐linking” step of the nanogels into individual dendritic particles. The present work gives a detailed insight in the particle degradation process, which is essential for further progress for the development of new drug delivery systems.
Differences in physical‐chemical properties of diaste‐reomeric salts allow the separation into the respective salts and subsequently into enantiomers by crystallization. Within this study unusual deviations in the cation‐/anion‐ratio of a diastereomeric salt pair were observed and characterized. While the n‐salt (L‐serine benzyl ester 2,3‐toluyl‐D‐tartrate) crystallizes in a ratio of two cations and one anion, the p‐salt (D‐serine benzyl ester 2,3‐toluyl‐D‐tartrate) consists of only one cation and one anion. Consequently the classical definition of a diastereomeric salt pair does not apply. In this contribution all differences in relevant thermodynamic properties of the unusual resulting diastereomeric salt pair are presented and discussed. 相似文献
In this work we demonstrate for the first time directly detected manganese-55 (55Mn) magnetic resonance imaging (MRI) using a clinical 3 T MRI scanner designed for human hyperpolarized 13C clinical studies with no additional hardware modifications. Due to the similar frequency of the 55Mn and 13C resonances, the use of aqueous permanganate for large, signal-dense, and cost-effective “13C” MRI phantoms was investigated, addressing the clear need for new phantoms for these studies. Due to 100% natural abundance, higher intrinsic sensitivity, and favorable relaxation properties, 55Mn MRI of aqueous permanganate demonstrates dramatically increased sensitivity over typical 13C phantom MRI, at greatly reduced cost as compared with large 13C-enriched phantoms. A large sensitivity advantage (22-fold) was demonstrated. A cylindrical phantom (d = 8 cm) containing concentrated aqueous sodium permanganate (2.7 M) was scanned rapidly by 55Mn MRI in a human head coil tuned for 13C, using a balanced steady state free precession acquisition. The requisite penetration of radiofrequency magnetic fields into concentrated permanganate was investigated by experiments and high frequency electromagnetic simulations, and found to be sufficient for 55Mn MRI with reasonably sized phantoms. A sub-second slice-selective acquisition yielded mean image signal-to-noise ratio of ~ 60 at 0.5 cm3 spatial resolution, distributed with minimum central signal ~ 40% of the maximum edge signal. We anticipate that permanganate phantoms will be very useful for testing HP 13C coils and methods designed for human studies. 相似文献
Versatile methods for the manipulation of individual quantum systems, such as confined particles, have become central elements in current developments in precision spectroscopy, frequency standards, quantum information processing, quantum simulation, and alike. For atomic and some subatomic particles, both neutral and charged, a precise control of magnetic fields is essential. In this paper, we discuss possibilities for the creation of specific magnetic field configurations which find application in these areas. In particular, we pursue the idea of a magnetic bottle which can be switched on and off by transition between the normal and the superconducting phase of a suitable material in cryogenic environments, for example, in trap experiments in moderate magnetic fields. Methods for a fine-tuning of the magnetic field and its linear and quadratic components in a trap are presented together with possible applications. 相似文献
We present a breadboard multi-conjugate adaptive optics (MCAO) system for high angular resolution solar observations which we operate at the Vacuum Tower Telescope. We have developed methods to estimate quantitatively the performance of solar adaptive optics from science data. Several sets of short exposure images of the solar photosphere were analyzed to assess the performance of the MCAO. We demonstrate that a 30 arcsec field of view is substantially improved when the MCAO system is turned on. This compares favourably with an improvement of a 10 arcsec field with conventional solar adaptive optics. We also show how irradiance fluctuations in the MCAO compensated focus can be suppressed. To cite this article: O. von der Lühe et al., C. R. Physique 6 (2005).相似文献
Various experimental methods are applied to retrieve the vibrational structure of phenanthrene in its neutral and cationic groundstates. The linear infrared (IR) absorption spectra in the 400-1650 cm(-1) range of jet-cooled phenanthrene and its cation, both clustered with either an argon or a neon atom, are obtained via photo-induced cluster dissociation spectroscopy. The spectra observed are in good agreement with calculated spectra of the bare species. However, the observed spectrum of cationic phenanthrene shows more lines and lines with different intensities in the 900-1400 cm(-1) range than expected from calculations. Additional spectra of the perdeuterated phenanthrene Ar cation, and the warm (T approximately > room temperature) bare phenanthrene cation are recorded. Also the mass-analyzed threshold ionization spectra of bare phenanthrene and phenanthrene-Ar are recorded and compared with each other. Comparison of the spectral data recorded to calculated spectra of bare neutral, cationic and cationic perdeuterated phenanthrene, as well as to IR spectra recorded in matrix-isolation experiments, explicitly demonstrates that cluster dissociation spectroscopy is a valid and powerful method to obtain IR spectroscopic information of bare neutral and cationic jet-cooled poly-aromatic hydrocarbons. 相似文献
A carbopalladation cascade reaction of easily accessible gem-dibromoolefins and alkynes furnishes monobenzo- and mononaphthopentalenes. The new chromophores accessed by this short route exhibit small HOMO-LUMO gaps and redox amphoteric behavior with tunable redox potentials. 相似文献
Within the last decade a huge increase in research activity in microfluidics could be observed. However, despite several commercial success stories, microfluidic chips are still not sold in high numbers in mass markets so far. Here we promote a new concept that could be an alternative approach to commercialization: designing microfluidic chips for existing off-the-shelf instruments. Such "Microfluidic Apps" could significantly lower market entry barriers and provide many advantages: developers of microfluidic chips make use of existing equipment or platforms and do not have to develop instruments from scratch; end-users can profit from microfluidics without the need to invest in new equipment; instrument manufacturers benefit from an expanded customer base due to the new applications that can be implemented in their instruments. Microfluidic Apps could be considered as low-cost disposables which can easily be distributed globally via web-shops. Therefore they could be a door-opener for high-volume mass markets. 相似文献