Tridiagonal canonical matrices of bilinear or sesquilinear forms and of pairs of symmetric,skew-symmetric,or Hermitian forms

Tridiagonal canonical forms of square matrices under congruence or *congruence, pairs of symmetric or skew-symmetric matrices under congruence, and pairs of Hermitian matrices under *congruence are given over an algebraically closed field of characteristic different from 2.     

Die Methoden zur direkten Messung des osmotischen Drucks

Ohne Zusammenfassung     

Zur leichteren Handhabung beim Arbeiten mit dem Nitrometer

Ohne Zusammenfassung     

Modified Boussinesq''s equations for nonuniform tire loading

Hypotheses from elasticity theory were used for modeling stress distribution in a semi-infinite-homogeneous medium when a point load was applied on its surface. A Concentration factor coefficient was introduced to adapt the equations to the characteristics of the investigated soil. An expression for continuous load distributions and variations in the geometry of the contact area between soil and tire were obtained by means of the superposition principle. Some simulations for different areas and load distributions are discussed and compared with field measurements.     

Bei Bestimmung von Paraffin, Ceresin und Mineral?len in Fetten und im Wachs

Ohne Zusammenfassung     

BMP-6 Loaded Polyelectrolyte Complex Nanoparticles Inducing Osteogenic Differentiation and Apoptosis of Malignant Plasma Cells for Local Treatment of Multiple Myeloma

In the malignant plasma cell disease multiple myeloma (MM), bone lesions and resulting fractures caused by MM cell (MMC) accumulation represent a major cause of morbidity and mortality. Despite recent advantages in systemic treatment, residual MMCs remain, especially in bone lesions. Therefore an interfacial delivery system for local treatment of MM and induced bone disease based on polyelectrolyte complex nanoparticles (PEC NP) loaded with bone morphogenetic protein 6 (BMP-6) inducing de-novo bone formation and MMC apoptosis is presented herein. BMP-6 loaded PEC NP are fabricated by defined mixing bio-related cationic and anionic polysaccharides and BMP-6 according to molar ratio of BMP-6/PEC-NP of 1/3. BMP-6/PEC NP bound to a model substrate releases 10% BMP-6 sustainably within two weeks as accessed by infrared spectroscopy. BMP-6 loaded PEC NP adheres to cell membranes of MMCs and MSCs and activated phosphorylation of Smad 1/5. Osteogenic differentiation (ALP-concentration) is enhanced in MSCs (p < 0.05). All patient samples (10/10) of MMCs show significant induction of apoptosis (median 84%, p < 0.05). Finally, BMP-6/PEC NP are successfully integrated in a commercial hyaluronic acid based hydrogel material revealing MMC death as principal proof for the local treatment of MM induced bone lesions.