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41.
Release property of reservoir device matrix tablet was examined. Wax matrix layer was prepared from physical mixture of lactose and hydrogenated castor oil to obtain basic release properties. Release process showed zero order kinetics in a steady state after a given lag times, and could be divided into two stages. The first stage was the formation process of water channel by dissolving the soluble component in the wax matrix layer. The lag time was considered to be the time required forming water channel and the time begun to release drug through the wax matrix layer at the same time. The lag time obtained by applying the square root law equation was well connected with the amount of matrix layer and mixed weight fraction of component in matrix layer. The second stage was the zero order release process of drug in the reservoir through the wax matrix layer. The release rate constants were calculated by taking into accounts of the thickness of matrix layer and permeability coefficient, and were well connected with the amount of matrix layer and mixed weight fraction of component. Also it was suggested that the tortuosity of matrix layer could be expressed by a function of the porosity defined by the mixed weight fraction. 相似文献
42.
Analysis of the entire release process of the wax matrix tablet was examined. Wax matrix tablet was prepared from a physical mixture of drug and wax powder to obtain basic or clear release properties. The release process began to deviate from Higuchi equation when the released amount reached at around the half of the initial drug amount. Simulated release amount increase infinitely when the Higuchi equation was applied. Then, the Higuchi equation was modified to estimate the release process of the wax matrix tablet. The modified Higuchi equation was named as the H-my equation. Release process was well treated by the H-my equation. Release process simulated by the H-my equation fitted well with the measured entire release process. Also, release properties from and through wax matrix well coincident each other. Furthermore, it is possible to predict an optional release process when the amount of matrix and composition of matrix system were defined. 相似文献
43.
44.
Tomoe Sanada Hisakazu Seto Yusuke Morimoto Kazuhiro Yamamoto Noriyuki Wada Kazuo Kojima 《Journal of Sol-Gel Science and Technology》2010,56(1):82-86
To develop new fluorescent and afterglow materials, Mn2+ and Eu3+ co-doped ZnO–GeO2 glasses and glass ceramics were prepared by a sol–gel method and their optical properties were investigated by measuring
luminescence, excitation and afterglow spectra, and luminescence quantum yield (QY). Under UV irradiation at 254 nm, some
glasses and all of the glass ceramics showed green luminescence peaking at 534 nm due to the 4T1 → 6A1 transition of tetrahedrally coordinated Mn2+ ions. The strongest luminescence was observed in a glass ceramic of 0.1MnO–0.3Eu2O3–25ZnO–75GeO2 heat treated at 900 °C, with QY of 49.8%. All of the green-luminescent glasses and glass ceramics showed green afterglow,
and the afterglow lasting for more than 60 min was obtained in a glass ceramic heat treated at 900 °C. It is considered that
the Eu3+ ions may behave as electron trapping centers to be associated with the occurrence of the green afterglow due to the Mn2+ ions in the co-doped system. 相似文献
45.
A FRET-based sensor protein presenting amyloid-like structures was successfully constructed for detecting the oligomeric assemblies of amyloid β-peptide (Aβ) wild-type and FAD-related mutants. 相似文献
46.
Kawasaki T Asaoka K Mihara H Okahata Y 《Journal of colloid and interface science》2006,294(2):295-303
Adsorption and aggregation of transformed peptides and proteins onto the cell membrane surface is commonly associated with forms of amyloidosis such as Alzheimer's disease and prion disease. To address dynamic features of these pathological phenomena molecularly, the in situ Ad-2alpha model peptide deposition on glycolipid-containing monolayers was studied by using a 9 MHz quartz-crystal microbalance (QCM). The Ad-2alpha peptide has two amphiphilic alpha-helix segments, each modified with a 1-adamantanecarbonyl group at the N-terminal as a hydrophobic defect. The peptide folds in a 2alpha-helix structure in the bulk solution. In the presence of mixed monolayers of glycolipids (GM1, asialo-GM1, GM3, or LacCer) and/or dipalmitoyl phosphatidylcholine (DPPC) laminated on the QCM plate, the peptide deposition and the conformational change to beta-structure on the monolayers were accelerated. The adsorption kinetics and the amount of Ad-2alpha were dependent on the sort and contents of the glycolipid in the DPPC matrix. Although the Ad-2alpha peptide adsorbs onto most of the glycolipid membranes as monolayer coverage, it adsorbed largely onto the GM1/DPPC (30/70 mol%) mixed monolayer with characteristic kinetic behaviors. The accumulation of beta-structured nonfibrous aggregations was confirmed by AFM and fluorescence microscopy with Thioflavin T (ThT). 相似文献
47.
In the pharmaceutical preparation of a controlled release drug, it is very important and necessary to understand the entire release properties. As the first step, the dissolution test under various conditions is selected for the in vitro test, and usually the results are analyzed following Drug Approval and Licensing Procedures. In this test, 3 time points for each release ratio, such as 0.2-0.4, 0.4-0.6, and over 0.7, respectively, should be selected in advance. These are analyzed as to whether their values are inside or outside the prescribed aims at each time point. This method is very simple and useful but the details of the release properties can not be clarified or confirmed. The validity of the dissolution test in analysis using a combination of the square-root time law and cube-root law equations to understand all the drug release properties was confirmed by comparing the simulated value with that measured in the previous papers. Dissolution tests under various conditions affecting drug release properties in the human body were then examined, and the results were analyzed by both methods to identify their strengths and weaknesses. Hereafter, the control of pharmaceutical preparation, the manufacturing process, and understanding the drug release properties will be more efficient. It is considered that analysis using the combination of the square-root time law and cube-root law equations is very useful and efficient. The accuracy of predicting drug release properties in the human body was improved and clarified. 相似文献
48.
Yuko Murakoshi Dr. Tsuyoshi Takahashi Prof. Dr. Hisakazu Mihara 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(14):4525-4531
Aggregation of amyloid β‐peptide (Aβ) is closely related to the pathogenesis of Alzheimer’s disease (AD). Although much effort has been devoted to the construction of molecules that inhibit the aggregation of Aβ1‐42, high doses are needed for the inhibition of Aβ aggregation in many cases. Previously, we reported that designed green fluorescent protein (GFP) analogues that gives pseudo‐Aβ β‐sheet structures can work as an aggregation inhibitor against Aβ. To further test this design strategy, we constructed protein analogues that mimic Aβ β‐sheet structures of amyloids by using insulin‐like growth factor 2 receptor domain 11 (IGF2R‐d11) as a scaffold. A designed protein, named IG11KK, which has a parallel configuration of Aβ‐like β sheets, can bind more preferentially to oligomeric Aβ1‐42 than the monomer. Moreover, IG11KK suppressed the aggregation of Aβ1‐42 efficiently, even though lower concentrations of IG11KK than Aβ were used. The aggregation kinetics of Aβ in the presence of the designed proteins revealed that IG11KK can work as an inhibitor not only for the early to middle stages, but also in the latter stage of Aβ aggregation owing to its favorable binding to oligomeric structures of Aβ. The design strategy using β‐barrel proteins such as IGF2R‐d11 and GFP is useful in generating excellent inhibitors of protein misfolding and amyloid formation. 相似文献
49.
信道空间衰落相关性(SFC)主要取决于波达信号的功率方位谱(PAS)和多天线阵列收发模式.深入研究了移动通信系统中多天线阵列SFC近似计算法及其复杂性.首先导出在典型PAS为均匀分布、高斯分布以及拉普拉斯分布下的SFC函数的闭合表达式.再研究在波达信号PAS小角度扩展时的近似计算法,建立多输入多输出(MIMO)多天线接收信道模型,深入分析所选择的天线阵列和电波传播参数对MIMO系统信道容量的影响.通过理论计算和仿真实验得出近似计算法在特定条件下具有很好的拟合度,定量分析了近似计算法在对MIMO多天线系统分析时的适用性和计算效率.该算法能极大地减低理论计算复杂性,提高分析和仿真MIMO多天线系统的效率. 相似文献
50.
We propose an improved framework for discussing the monopole catalysis of proton decay. Instead of discarding higher partial waves from the outset we integrate over them and obtain the s-wave effective action. We present a detailed calculation to confirm that the effects of higher partial waves through one-loop radiative corrections neither spoil nor modify the conventional treatment of monopole catalysis of proton decay. 相似文献