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141.
Yamamoto K Isogai Y Sato H Taketomi Y Murakami M 《Analytical and bioanalytical chemistry》2011,400(7):1829-1842
Phospholipase A2 (PLA2) is a group of enzymes that hydrolyze the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Of many PLA2s or related enzymes identified to date, secreted PLA2s (sPLA2s) comprise the largest family that contains 10 catalytically active isozymes. Besides arachidonic acid released from cellular
membranes for eicosanoid synthesis, several if not all sPLA2s have recently been implicated in hydrolysis of phospholipids in lipoprotein particles. The sPLA2-processed low-density lipoprotein (LDL) particles contain a large amount of lysophospholipids and exhibit the property of
“small-dense” or “modified” LDL, which facilitates foam cell formation from macrophages. Transgenic overexpression of these
sPLA2s leads to development of atherosclerosis in mice. More importantly, genetic deletion or pharmacological inhibition of particular
sPLA2s significantly attenuates atherosclerosis and aneurysm. In this article, we will give an overview of current understanding
of the role of sPLA2s in atherosclerosis, with recent lipidomics data showing the action of a subset of sPLA2s on lipoprotein phospholipids. 相似文献
142.
Takeshi MiyazakiHirofumi Maekawa Kazuaki YonemuraYoshimasa Yamamoto Yoshiko YamanakaIkuzo Nishiguchi 《Tetrahedron》2011,67(8):1598-1602
Treatment of various types of aromatic δ-ketoesters 2, 7, and 9 with Mg-turnings for Grignard reaction at −5 to 0 °C in N,N-dimethylformamide (DMF) containing trimethylsilyl chloride (TMSCl) brought about selective and reductive intramolecular cyclization to give the corresponding α-aryl-α-hydroxycyclopentanones 5, 8, and 10, respectively, in moderate to good yields. Similar reductive intramolecular cyclization of aromatic δ-ketodiesters 14, followed by acidic hydrolysis and decarboxylation easily gave the corresponding 2-aryl-2-cyclopenten-1-ones 15. The present facile coupling may be initiated through electron transfer from Mg metal to the aromatic carbonyl groups of 2, 7, 9, and 14 to generate the corresponding radical anions, followed by their intramolecular nucleophilic attack to the ester groups to give the corresponding five-membered ring compounds 5, 8, 10, and 15, respectively. 相似文献
143.
Zheng Y Hashidzume A Takashima Y Yamaguchi H Harada A 《Langmuir : the ACS journal of surfaces and colloids》2011,27(22):13790-13795
Macroscopic molecular recognition observations were realized using polyacrylamide-based gels modified with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), 1-naphthylmethyl (1Np), and 2-naphthylmethyl (2Np) moieties, which are denoted as αCD(x)-gel, βCD(x)-gel, 1Np(y)-gel, and 2Np(y)-gel, where x and y indicate the mol % of CD and Np moieties, respectively. The αCD(5)-gel did not adhere to either the 1Np(5)-gel or 2Np(5)-gel, whereas the βCD(5)-gel interacted with both to form alternating or checkered assemblies. Although the difference in the association constants of β-CD for the model polymers was small, the βCD(x)-gel successfully discriminated between 1Np(y)-gel and 2Np(y)-gel at the appropriate x and y. 相似文献
144.
Dr. Felipe Gándara Dr. Fernando J. Uribe‐Romo Dr. David K. Britt Dr. Hiroyasu Furukawa Dr. Liao Lei Rui Cheng Prof. Xiangfeng Duan Prof. Michael O'Keeffe Prof. Omar M. Yaghi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(34):10595-10601
A new family of porous crystals was prepared by combining 1H‐1,2,3‐triazole and divalent metal ions (Mg, Mn, Fe, Co, Cu, and Zn) to give six isostructural metal‐triazolates (termed MET‐1 to 6). These materials are prepared as microcrystalline powders, which give intense X‐ray diffraction lines. Without previous knowledge of the expected structure, it was possible to apply the newly developed charge‐flipping method to solve the complex crystal structure of METs: all the metal ions are octahedrally coordinated to the nitrogen atoms of triazolate such that five metal centers are joined through bridging triazolate ions to form super‐tetrahedral units that lie at the vertexes of a diamond‐type structure. The variation in the size of metal ions across the series provides for precise control of pore apertures to a fraction of an Angstrom in the range 4.5 to 6.1 Å. MET frameworks have permanent porosity and display surface areas as high as some of the most porous zeolites, with one member of this family, MET‐3, exhibiting significant electrical conductivity. 相似文献
145.
Kawai H Okusu S Tokunaga E Sato H Shiro M Shibata N 《Angewandte Chemie (International ed. in English)》2012,51(20):4959-4962
Ether way: the cinchona-alkaloid-catalyzed title reaction was achieved in high yields with high to excellent ee values for the first time, and affords key intermediates for the biologically important 2 having a trifluoromethylated all-carbon quaternary chiral center. Ether-type catalysts (1) are more efficient in this transformation than the conventional hydroxy analogues. 相似文献
146.
We newly synthesized various sized gold nanoparticles covered with photochromic polymers consisting of diarylethenes with various structures to investigate an effect of the gold nanoparticles on the photocycloreversion reaction of the diarylethene chromophores upon irradiation with visible light. The gold nanoparticles covered with the photochromic polymers exhibited reversible changes in localized surface plasmon resonance (LSPR) absorption along with the photochromic reaction depending on the diameter of the particle, the distance between the gold surface and the chromophore, and the structure of the diarylethene chromophore. The rate of the photocycloreversion reaction of the chromophores around the particle was enhanced by the gold nanoparticles and the degree of the enhancement was affected by the diameter of the particle and the distance from the gold surface, while a structural difference in the diarylethene chromophore had no effect on the degree of the enhancement. The larger enhancement of the photocycloreversion reaction was observed by irradiation at longer wavelength side than visible light corresponding to the LSPR frequency. 相似文献
147.
Tohru Takahashi Masatoshi Yoshimura Hiroyasu Suzuka Tomohiro Maegawa Yoshinari Sawama Yasunari Monguchi Hironao Sajiki 《Tetrahedron》2012,68(39):8293-8299
Palladium catalysts embedded on molecular sieves (MS3A and MS5A) were prepared by the adsorption of Pd(OAc)2 onto molecular sieves with its in situ reduction to Pd0 by MeOH as a reducing agent and solvent. 0.5% Pd/MS3A and 0.5% Pd/MS5A catalyzed the hydrogenation of alkynes, alkenes, and azides with a variety of coexisting reducible functionalities, such as nitro group, intact. It is noteworthy that terminal alkenes of styrene derivatives possessing electron-donating functionalities on the benzene nucleus were never hydrogenated under 0.5% Pd/MS5A-catalyzed conditions, while internal alkenes of 1-propenylbenzene derivatives were readily reduced to the corresponding alkanes. 相似文献
148.
A necessary and sufficient condition of the possibility of a deterministic local operations and classical communication (LOCC) transformation of three-qubit pure states is given. The condition shows that the three-qubit pure states are a partially ordered set parametrized by five well-known entanglement parameters and a novel parameter; the five are the concurrences CAB, CAC, CBC, the tangle τABC and the fifth parameter J5 of Acín et al. (2000) Ref. [19], while the other new one is the entanglement charge Qe. The order of the partially ordered set is defined by the possibility of a deterministic LOCC transformation from a state to another state. In this sense, the present condition is an extension of Nielsen’s work (Nielsen (1999) [14]) to three-qubit pure states. We also clarify the rules of transfer and dissipation of the entanglement which is caused by deterministic LOCC transformations. Moreover, the minimum number of times of measurements to reproduce an arbitrary deterministic LOCC transformation between three-qubit pure states is given. 相似文献
149.
Hajimo Yoshida Takejiro Kaneko Hiroyasu Fujimori Hiroaki Morita Koshichi Noto Kazuo Kamigaki 《高压研究》2013,33(1-6):114-116
Abstract The effect of pressure on Tc was studied on 110 K class Bi-Sr-Ca-Cu-O (1:1:1:2) compounds. Tc was varied with current in I3/2 , and defined at the value extrapolated to zero current. dTc /dP = + 0.18 K/kbar was obtained up to 10.9 kbars. 相似文献
150.
Forgan RS Smaldone RA Gassensmith JJ Furukawa H Cordes DB Li Q Wilmer CE Botros YY Snurr RQ Slawin AM Stoddart JF 《Journal of the American Chemical Society》2012,134(1):406-417
The binding of alkali and alkaline earth metal cations by macrocyclic and diazamacrobicyclic polyethers, composed of ordered arrays of hard oxygen (and nitrogen) donor atoms, underpinned the development of host-guest supramolecular chemistry in the 1970s and 1980s. The arrangement of -OCCO- and -OCCN- chelating units in these preorganized receptors, including, but not limited to, crown ethers and cryptands, is responsible for the very high binding constants observed for their complexes with Group IA and IIA cations. The cyclodextrins (CDs), cyclic oligosaccharides derived microbiologically from starch, also display this -OCCO- bidentate motif on both their primary and secondary faces. The self-assembly, in aqueous alcohol, of infinite networks of extended structures, which have been termed CD-MOFs, wherein γ-cyclodextrin (γ-CD) is linked by coordination to Group IA and IIA metal cations to form metal-organic frameworks (MOFs), is reported. CD-MOF-1 and CD-MOF-2, prepared on the gram-scale from KOH and RbOH, respectively, form body-centered cubic arrangements of (γ-CD)(6) cubes linked by eight-coordinate alkali metal cations. These cubic CD-MOFs are (i) stable to the removal of solvents, (ii) permanently porous, with surface areas of ~1200 m(2) g(-1), and (iii) capable of storing gases and small molecules within their pores. The fact that the -OCCO- moieties of γ-CD are not prearranged in a manner conducive to encapsulating single metal cations has led to our isolating other infinite frameworks, with different topologies, from salts of Na(+), Cs(+), and Sr(2+). This lack of preorganization is expressed emphatically in the case of Cs(+), where two polymorphs assemble under identical conditions. CD-MOF-3 has the cubic topology observed for CD-MOFs 1 and 2, while CD-MOF-4 displays a channel structure wherein γ-CD tori are perfectly stacked in one dimension in a manner reminiscent of the structures of some γ-CD solvates, but with added crystal stability imparted by metal-ion coordination. These new MOFs demonstrate that the CDs can indeed function as ligands for alkali and alkaline earth metal cations in a manner similar to that found with crown ethers. These inexpensive, green, nanoporous materials exhibit absorption properties which make them realistic candidates for commercial development, not least of all because edible derivatives, fit for human consumption, can be prepared entirely from food-grade ingredients. 相似文献