Etude structurale de la forme ordonnée de LiAl5O8

A single crystal of ordered LiAl₅O₈ has been prepared by image furnace melting and its structure has been determined; 400 X-ray reflections were collected on an automatic counter diffractometer (MoKα radiation). The structure is of the spinel type. The space group is P4₃32 (or P4₁32); the lattice parameter is a = 7.908(2), Å, Z = 4. The value of R is 0.022. The distribution of cations shows the absence of Li⁺ ions in tetrahedral cation sites and 1–3 imperfect ordering of Li⁺ and Al₃₊ in octahedral cation sites of spinel.     

Synthesis of a 10,000 member 1,5-benzodiazepine-2-one library by the directed sorting method

The solid-phase synthesis of a 10,000 member combinatorial library of 1,5-benzodiazepine-2-one derivatives is reported. The 3-amino-1,5-benzodiazepine-2-one scaffold was prepared in solution, and the benzamide nitrogen was used as a point of attachment to the resin. The 5-aniline and 3-amine were then used as points of diversity. A 10,000 member library was synthesized using the Irori directed sorting system, and after analysis of a representative sample from the library, the Irori system was used to remove the compounds of lower purity.