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941.
Elionai Cassiana de Lima Gomes Izabella Ercole de Carvalho Silvia Ligório Fialho Jamile Barbosa Maria Irene Yoshida Armando da Silva Cunha Júnior 《Journal of Thermal Analysis and Calorimetry》2018,131(3):2123-2128
Most of the pharmaceutical products are formulated as solid dosage form, which may present drug–excipient interactions that lead to changes in the chemical nature of the drug, such as solubility and bioavailability and may compromise its safety and effectiveness. Differential scanning calorimetry (DSC) is a widely used method for the rapid evaluation of the drug-excipient compatibility and the stability of the mixture formed; however, there is no consensus on the preparation methods of the drug–excipient mixtures. The aim of this study was to investigate the influence of the mixing method on the drug–excipient compatibility studies by means of DSC analysis, using tenofovir disoproxil fumarate as a drug model. Statistical analysis revealed significant differences in the heat of fusion of the drug in the mixtures prepared by several mixing methods. Vortex Mixer with a Pop-Off Cup used for 3 min proved to be very satisfactory for these studies. A polymorphic transition was observed in the mixture prepared with the mortar and pestle. Therefore, this method should be avoided since it may induce errors in the interpretation of DSC results. In this way, the mixing method used to prepare a mixture for studies of interactions between the API and the excipients in a pharmaceutical formulation has a great influence on the results and it must be chosen carefully. 相似文献
942.
A polyacrylonitrile (PAN) homopolymer and a copolymer with methyl acrylate were analyzed by differential scanning calorimetry (DSC) in order to establish a method for the kinetic analysis of the stabilization reaction steps during heat treatment. The application of a program rarely used for the study of the chemical transformation of PAN and its copolymers resulted in five separate steps, which can be assigned with large probability to various cyclization and oxidation reactions. A more exact identification of the reactions needs further measurements and considerations. Overlapping peaks appearing in the DSC traces were deconvoluted and then quantitatively analyzed to obtain kinetic parameters. The kinetics of the processes were described by the Kissinger model. The model could be fitted well to four of the five processes that may indicate that these belong to individual reactions of the first order. The parameters obtained agree well with the few values of similar investigations published in the literature up to now. The results have large practical relevance, since the kinetic parameters obtained can be used in the preparation of intermediates and for the optimization of the stabilization process. 相似文献
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