A New Validated Potentiometric Method for Batch and Continuous Quality Control Monitoring of Oseltamivir Phosphate (Taminil) in Drug Formulations and Biological Fluids

A new validated potentiometric method is described for batch and continuous quality control monitoring of the drug oseltamivir phosphate (Taminil) (OST). The method involves the development of a potentiometric sensor responsive to the drug based on the use of the ion‐association complex of (OST⁺) cation with phosphomolybdate anion (PMA^?) as an electroactive material in a poly(vinyl chloride) matrix membrane plasticized with o‐nitrophenyloctyl ether (o‐NPOE). Optimization of the performance characteristics of the sensor is described. A membrane incorporating the OST‐PMA‐NPOE complex in a tubular flow through detector is used in a two channel flow injection set up for continuous monitoring of the drug at a frequency of ～30 samples h^?1. The sensor shows fast near‐Nernstian response for OST over the concentration range 5.2×10^?5–0.8×10^?2 M (21.34 µg mL^?1–3.23 mg mL^?1) with a detection limit of 9.1×10^?6 M (3.73 µg mL^?1) over the pH range 4.6–6.1. The sensor displays good selectivity for OST drug over some basic drugs, inorganic cations, excipients and diluents commonly used in the drug formulations. Validation of the assay method is tested by measuring the lower detection limit, range, linearity, bias, trueness, accuracy, precision, and between‐day‐variability, within day reproducibility, selectivity and ruggedness (robustness). The results reveal good potentiometric performance of the proposed sensor for determination of OST in pharmaceutical capsules and in biological fluid matrices as well as for testing the dissolution profile of the drug and drug homogeneity.     

R-Deformed Heisenberg Algebra, Quantum Mechanics, and Virasoro Algebra

We review the R-deformed Heisenberg algebra and its Fock space representation.We construct the R-deformed quantum mechanics in N dimensions, and proposea new R-deformed Virasoro algebra.     

Momentum spectra for dynamically assisted Schwinger pair production

Recently the dynamically assisted Schwinger mechanism, i.e., electron–positron pair production from vacuum by a combination of laser pulses with different time scales has been proposed. The corresponding results, which suggest that the rate of produced pairs is significantly enhanced by dynamical effects, are verified. Employing the framework of quantum kinetic theory intrinsically enables us to additionally provide momentum space information on the generated positron spectrum.     

Imaging cluster surfaces with atomic resolution: the strong metal-support interaction state of Pt supported on TiO2(110)

Nanosized platinum clusters were grown on a TiO2(110) surface and annealed in ultrahigh vacuum at high temperatures. This leads to the so-called strong metal-support interaction (SMSI) state, characterized by a complete encapsulation of the clusters with a reduced titanium oxide layer. We present atomically resolved scanning tunneling microscopy measurements of the cluster surfaces and an atomic model of the SMSI state. The ability to resolve the cluster surface geometry with atomistic detail may help to identify the active sites responsible for the SMSI.     

Iterative Methods for Systems of First-order Differential Equations

In this paper, we study the applicability of the iterative asynchronousalgorithms to systems of first order differential equations.These algorithms can be implemented on monoprocessors as wellas on multiprocessors, therefore this study extends Picard'smethod and opens a future perspective for treating differentialsystems in a parallel and asynchronous manner using multiprocessors     

One-nucleon transfer reactions in the12C+12C system at 344.5 MeV

Angular distributions of cross sections have been measured for single nucleon transfer reactions induced by 344.5 MeV¹²C ions on a¹²C target. DWBA analyses have been performed for transitions to discrete final states. Spectroscopic information has been derived and is compared with results of other studies.     

Macroscopic Equations for a Multicomponent Plasma

From the balance equations for partial quantities we derive equations for lumped quantities, e.g. a generalized Ohm's law. They are especially useful for a three-component system (electrons, one species of ions and neutral particles). Certain conditions are derived and investigated to describe a plasma with more than three components by the lumped quantities.     

Optimization Studies of Porous Carbon Preparation from Oil Shale Using Response Surface Methodology and Its Application for Phenol Adsorption

This paper discusses the elaboration of adsorbents from oil shale. The experimental designs a response surface methodology(RSM), which has been applied to optimize the significant preparation factors, such as temperature, time, and the activating agent percentage. The results obtained from central composite design(CCD) revealed that the interaction between the factors was significant for the maximum quantity of adsorption(response). Planned results have shown that a maximum quantity of adsorption for methylene blue is 65 mg/g, which could be achieved with a temperature of 275℃ over 2 h and a percentage of the activating agent of 45%. The predicted values agreed with the experimental finding, with a determination coefficient(R²) of 0.96. The model has been validated by experiments after conditions optimization. The new material(RHO) was characterized by cation exchange capacity, zero charge pH, surface functions, X-ray fluorescence, specific surface area, and electron microscopy analysis. Phenol adsorption was determined using Langmuir, Freundlich and Temkin, which were used to describe the adsorption isotherms. The adsorption capacity of the material was about 263 mg/g, and the kinetic studies showed rapid adsorption.