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排序方式: 共有1213条查询结果,搜索用时 31 毫秒
121.
Kim T Momin E Choi J Yuan K Zaidi H Kim J Park M Lee N McMahon MT Quinones-Hinojosa A Bulte JW Hyeon T Gilad AA 《Journal of the American Chemical Society》2011,133(9):2955-2961
Mesoporous silica-coated hollow manganese oxide (HMnO@mSiO(2)) nanoparticles were developed as a novel T(1) magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of the nanoparticle shell enables optimal access of water molecules to the magnetic core, and consequently, an effective longitudinal (R(1)) relaxation enhancement of water protons, which value was measured to be 0.99 (mM(-1)s(-1)) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) were efficiently labeled using electroporation, with much shorter T(1) values as compared to direct incubation without electroporation, which was also evidenced by signal enhancement on T(1)-weighted MR images in vitro. Intracranial grafting of HMnO@mSiO(2)-labeled MSCs enabled serial MR monitoring of cell transplants over 14 days. These novel nanoparticles may extend the arsenal of currently available nanoparticle MR contrast agents by providing positive contrast on T(1)-weighted images at high magnetic field strengths. 相似文献
122.
A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2-thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazole-2-thioesters in the presence of hydrazine hydrate and absolute alcohol. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The synthesized compounds were evaluated for their in vitro antifungal activity. Some of the evaluated compounds possessed significant antifungal activity as compared to a terbinafine standard. 相似文献
123.
Aliabadi HM Landry B Bahadur RK Neamnark A Suwantong O Uludağ H 《Macromolecular bioscience》2011,11(5):662-672
Characterization of a polymer library engineered to enhance their ability to protect and deliver their nucleotide cargo to the cells is reported. The ζ-potential continuously increased with higher polymer:siRNA weight ratio, and the ζ-potential of lipid-modified polymers:siRNA complexes were higher than PEI2 at all ratios. At polymer:siRNA ratio of 1:1, all lipid-substituted polymers showed complete protection against degradation. Lipid-modified polymers significantly increased the cellular uptake of siRNA complexes and down-regulation of GAPDH and P-gp (max. 66% and 67%, respectively). The results indicate that hydrophobic modification of low molecular PEI could render this otherwise ineffective polymer to a safe effective delivery system for intracellular siRNA delivery and protein silencing. 相似文献
124.
Kitamura T Morshed MH Tsukada S Miyazaki Y Iguchi N Inoue D 《The Journal of organic chemistry》2011,76(19):8117-8120
Phenyl(trimethylsilylethynyl)iodonium and tert-butyldimethylsilylethynyl(phenyl)iodonium triflates were applied to alkynylation of benzotriazole. Treatment of the silylethynyliodonium triflates with the potassium salt of benzotriazole ion in (t)BuOH and CH(2)Cl(2) gave 2-(trimethylsilylethynyl)-2H-1,2,3-benzotriazole and 2-(tert-butyldimethylsilylethynyl)-2H-1,2,3-benzotriazole in 74% and 76% yields, respectively. The regioisomers, 1-silylethynyl-1H-1,2,3-benzotriazole derivatives, were minor. In both cases of the silyl-substitued ethynyliodonium salts, novel regioselective alkynylation of benzotriazole at the 2 position was observed. 相似文献
125.
Shekhah O Arslan HK Chen K Schmittel M Maul R Wenzel W Wöll C 《Chemical communications (Cambridge, England)》2011,47(40):11210-11212
Thin films of MOFs grown on solid substrates offer a huge potential with regard to tailoring the properties of a surface, in particular if used in connection with post-synthesis modification (PSM). Here, we report on the PSM of surface-supported crystalline MOFs, with target molecules using an amine-based coupling strategy. 相似文献
126.
Hasan Demir Moghtada Mobedi Semra Ülkü 《Journal of Thermal Analysis and Calorimetry》2011,104(1):375-382
In this study, the activities of four ginsenosides Rc, Re, Rd, and Rf on splenic lymphocytes growth were studied by microcalorimetry.
Some qualitative and quantitative information, such as the metabolic power–time curves, growth rate constant k, maximum heat-output power of the exponential phase P
max and the corresponding appearance peak time t
max, total heat output Q
t, and promotion rate R
p of splenic lymphocytes growth affected by the four ginsenosides were calculated. In accordance with thermo-kinetic model,
the corresponding quantitative relationships of k, P
max, t
max, Q
t, R
p, and c were established, . Also, the median effective concentration (EC50) was obtained by quantitative analysis. Based on both the quantitative quantity–activity relationships (QQAR) and EC50, the sequence of promotion activity was Rc > Re > Rd > Rf. The analysis of structure–activity relationships showed that the
number, type, and position of sugar moieties on the gonane steroid nucleus had important influences on the promotion activity
of Rc, Re, Rd, and Rf on splenic lymphocytes growth. Microcalorimetry can be used as a useful tool for determining the activity
and studying the quantity–activity relationship of drugs on cell. 相似文献
127.
A series of 1,3,5-triaryl-2-pyrazolines was synthesized by dissolving the corresponding 4-alkoxychalcones in glacial acetic acid containing a few drops of concentrated hydrochloric acid. This step was followed by the addition of (3,4-dimethylphenyl) hydrazaine hydrochloride. Finally the target compounds were precipitated by pouring the reaction mixture onto crushed ice. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The 1,3,5-triaryl-2-pyrazolines bearing homologous alkoxy groups were found to possess fluorescence properties in the blue region of the visible spectrum when irradiated with ultraviolet radiation. The fluorescent behavior of these compounds was studied by UV-Vis and emission spectroscopy, performed at room temperature. 相似文献
128.
Sweeney CM Nehl CL Hasan W Liang T Eckermann A Meade TJ Odom TW 《The journal of physical chemistry. C, Nanomaterials and interfaces》2011,115(32):15933-15937
A three-channel spectrometer (3CS) based on a commercial digital camera was developed to distinguish among tens of large (>100 nm), anisotropic plasmonic particles with various shapes, orientations, and compositions on a surface simultaneously. Using band pass filters and polarizers, the contrast of 3CS images could be enhanced to identify specific orientation and composition characteristics of gold and gold-silver nanopyramids and as well as the direction of the longest arm of gold nanostars. 相似文献
129.
Kirmizibekmez H Atay I Kaiser M Yesilada E Tasdemir D 《Natural product communications》2011,6(11):1697-1700
The in vitro antiprotozoal activities of crude methanolic extracts from the aerial parts of five Lamiaceae plants (Salvia tomentosa, S. sclarea, S. dichroantha, Nepeta nuda subsp. nuda and Marrubium astracanicum subsp. macrodon) were evaluated against four parasitic protozoa, i.e. Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum. The cytotoxic potentials of the extracts on L6 cells were also evaluated. Melarsoprol, benznidazole, miltefosine, chloroquine and podophyllotoxin were used as reference drugs. All crude MeOH extracts showed antiprotozoal potential against at least three parasites, so they were dispersed in water and partitioned against n-hexane and chloroform to yield three subextracts that were screened in the same test systems. The n-hexane extract of N. nuda was the most active against T. brucei rhodesiense while the CHCl3 extracts of S. tomentosa and S. dichroantha showed significant activity against L. donovani. All organic extracts displayed in vitro antimalarial and moderate trypanocidal activities against T. cruzi with the n-hexane extract of S. sclarea being the most active against the latter. The extracts displayed low or no cytotoxicity towards mammalian L6 cells. 相似文献
130.
Mohammad Pourmahmood Aghababa Hasan Pourmahmood Aghababa 《Mechanics Research Communications》2011,38(7):500-505
This paper deals with the problem of robust finite-time stabilization of non-autonomous chaotic gyrostat systems. It is assumed that the parameters of the gyrostat system are completely unknown in advance and the system is perturbed by unknown uncertainties and disturbances. Some update laws are proposed to estimate the unknown parameters. Based on the finite-time control idea and the update laws, appropriate control laws are designed to ensure the stabilization of the closed-loop system in a finite time. The finite-time stability and convergence of the closed-loop system are analytically proved. A numerical simulation is given to demonstrate the applicability and robustness of the proposed finite-time controller and to verify the theoretical results. 相似文献