Metal and acid-free visible light-mediated Friedel-Crafts alkylation reactions of indole with anilines

Metal and acid-free visible light-induced Friedel-Crafts C3-alkylation reactions of indole derivatives were developed using N,N-dimethylanilines as the carbon source. A cheap and readily available organic dye, Rose Bengal, was applied as the photocatalyst. This environmentally friendly transformation afforded C3-alkylated indoles in moderate to good yields under mild conditions.     

Size and support effects for CO oxidation on supported Pd catalysts

Science China Chemistry - Supporting Pd catalysts characterized significant different size distribution were obtained using PdCl2, [Pd(NH3)4](NO3)2 and Pd(acac)2 as precursors. High-resolution...     

In vivo activation analysis of organ cadmium using the Tsing Hua Mobile Educational Reactor

This work describes a nuclear facility forin vivo prompt gamma activation analysis (IVPGAA) using a moderated neutron beam from a 0.1 W Tsing-Hua Mobile Educational Reactor (THMER). The IVPGAA measurement is a new technique for toxic cadmium determination in organs, which can efficiently be used in clinical diagnosis. The low-power nuclear reactor provides a total neutron flux of 3.3·10⁴ n·cm^–2·s^–1 on the surface of the central vertical neutron beam tube to which a liquid phantom is positioned. The capability of such partial-body irradiation facility is demonstrated. The detection limit of cadmium in the left kidney for a skin dose equivalent of 1.66 mSv (166 mrem) was 1.34 mg in a 500-s irradiation/counting period, and the sensitivity in the left kidney was 103 counts mg^–1·mSv^–1. The performance of IVPGAA system using the THMER nuclear facility therefore has the advantages of mobility and feasibility with high sensitivity under low neutron and gamma doses.     

“元素化学实验”中的“异常”现象(一)--Mn元素化学实验中的“异常”现象及其探析

大一学生在“元素化学实验”教学过程中,对反应条件如温度、催化剂、酸度、浓度或试剂用量等因素的影响考虑不周,可能出现某些实验现象和预想的或理论分析的结果不一致的“异常”现象。本文就学生在Mn元素化学实验过程中遇到的一些“异常”现象进行分析和总结,借助生动直观的演示实验,引导学生探究“异常”现象产生的可能原因和直观认识反应条件对反应结果的影响,培养学生的观察、分析、判断、归纳、推理和解决实际问题的能力。     

加强实验教学环境内涵建设 提高环境育人质量

在实验室里的实验教学过程涉及到教书育人、管理育人、服务育人和环境育人。一个良好的实验环境不仅能够对学生起到潜移默化的教育作用,而且对教书育人、管理育人和服务育人工作的开展和实施也能起到推动和促进作用。本文主要介绍厦门大学化学国家级实验教学示范中心"以学生为中心",在强化实验教学环境内涵建设、提高实验环境育人质量方面的一些做法和体会,以期更好地为实验教学"思政"提供可复制、可推广的建设方案。     

反相高效液相色谱法测定尿中吡啶醚和脱氧吡啶醚

尿中吡啶醚（ｐｙｒｉｄｉｎｏｌｉｎｅ,ＰＹＤ）和脱氧吡啶醚（ｄｅｏｘｙｐｙｒｉｄｉｎｏｌｉｎｅ,ＤＰＤ）是骨代谢特异的生化指标。应用高效液相色谱法（ＨＰＬＣ）建立了尿中ＰＹＤ和ＤＰＤ的测定方法。尿液用６ｍｏｌ／ＬＨＣｌ水解后,以纤维素ＣＦ１小柱提取,然后用ＨＰＬＣ测定;色谱系统为ＳｐｈｅｒｉｓｏｒｂＣ１８反相色谱柱,流动相组成为１５％甲醇添加０．１％七氟丁酸,流速为１．２ｍＬ／ｍｉｎ。系统的检测限：ＰＹＤ为１０ｎｍｏｌ／Ｌ,ＤＰＤ为７ｎｍｏｌ／Ｌ;回收率：ＰＹＤ为９１．５％,ＤＰＤ为１０６．１％;日内变异     

Organostannate derivatives of dicyclohexylammonium hydrogen 2,6-pyridinedicarboxylate: solution/solid-state 13C,119Sn NMR and in vitro antitumour activity of bis(dicyclohexylammonium) bis(2,6-pyridinedicarboxylato)dibutylstannate,and the crystal structure of its monohydrate

Bis(dicyclohexylammonium) bis(2,6-pyridinedicarboxylato)dibutylstannate is assigned seven-fold coordination at tin on the basis of its ¹¹⁹Sn CP/MAS NMR chemical shift (δ=−424.9 ppm). The assignment has been corroborated by a crystal structure determination of its monohydrate, whose tin atom has the trans -C₂SnNO₄ pentagonal bipyramidal [Sn–C=2.040(9), 2.067(8) Å; C–Sn–C =168.9(5)°] geometry. One 2,6-pyridine- dicarboxylato group chelates to the tin atom (Sn–O=2.234(4), 2.260(4); Sn–N =2.279(5) Å) whereas the other binds through only one carboxyl –CO₂ end (Sn–O=2.416(5), 2.441(5) Å). Hydrogen bonds link the cation and the stannate into a linear chain parallel to the b -axis. The lattice water molecule is hydrogen-bonded to the free carboxyl end. The anhydrous compound showed higher in vitro antitumor activity than those of carboplatin and cisplatin when screened against breast (MCF-7, EVSAT), colonic (WiDr), ovarian (IGROV) and renal (A498) carcinoma, and melanoma (M19 MEL) cell lines. © 1997 by John Wiley & Sons, Ltd.     

Pd‐Catalyzed Dearomatization of Anthranils with Vinylcyclopropanes by [4+3] Cyclization Reaction

Dearomatization of anthranils with vinylcyclopropanes (VCPs) by Pd‐catalyzed [4+3] cyclization reaction has been realized. In the presence of a catalytic amount of borane as an activator, bridged cyclic products were obtained in good to excellent yields with excellent stereoselectivities. By introducing a chiral PHOX ligand ( L5 ), asymmetric dearomatization reactions of anthranils with vinylcyclopropanes proceeded with excellent enantioselectivity. Borane plays a key role for the reactivity, likely owing to the formation of a borane–anthranil complex which has been confirmed by NMR experiments.