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131.
Lateral diffusion measurements, most commonly accomplished through Fluorescence Photobleaching Recovery (FPR or FRAP), provide
important information on cell membrane molecules' size, environment and participation in intermolecular interactions. However,
serious difficulties arise when these techniques are applied to weakly expressed proteins of either of two types: fusions
of membrane receptors with visible fluorescent proteins or membrane molecules on autofluorescent cells. To achieve adequate
sensitivity in these cases, techniques such as interference fringe FPR are needed. However, in such measurements, cytoplasmic
species contribute to the fluorescence recovery signal and thus yield diffusion parameters not properly representing the small
number of surface molecules. A new method helps eliminate these difficulties. High Probe Intensity (HPI)-FPR measurements
retain the intrinsic confocality of spot measurements to eliminate interference from fluorescent cytoplasmic species. However,
HPI-FPR methods lift the previous requirement that FPR procedures be performed at probe beam intensities low enough to not
induce bleaching in samples during measurements. The high probe intensities now employed provide much larger fluorescence
signals and thus more information on molecular diffusion from each measurement. We report successful measurement of membrane
dynamics by this technique. 相似文献
132.
Piotto M Elbayed K Wieruszeski JM Lippens G 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2005,173(1):84-89
High resolution magic angle spinning (HRMAS) has become an extremely versatile tool to study heterogeneous systems. HRMAS relies on magic angle spinning of the sample to average out to zero magnetic susceptibility differences in the sample and to obtain resonance linewidths approaching those of liquid state NMR. Shimming such samples therefore becomes an important issue. By analyzing the different sources of magnetic field perturbations present in a sample under MAS conditions, we propose a simple protocol to obtain optimum shim settings in HRMAS. In the case of aqueous samples, we show that the lock level cannot be used as a reliable indicator of the quality of the shims at high spinning speeds. This effect is explained by the presence of temperature gradients imparted by the sample rotation. 相似文献
133.
Harris SE Orpen AG Bruno IJ Taylor R 《Journal of chemical information and modeling》2005,45(6):1727-1748
Metal-ligand (M-L) bond lengths for a range of ligands (carboxylates, chlorides, pyridines, water, tertiary phosphines, and alkenes) and a variety of metals have been retrieved from the Cambridge Structural Database, CSD. Analysis of the factors which affect M-L bond lengths (for example, ligand coordination mode, oxidation state, metal coordination number and geometry, spin and Jahn-Teller effects, and ligand trans to M-L bond) shows that it is generally possible to subdivide the M-L data sets systematically to obtain better defined, unimodal, bond length distributions with means and sample standard deviations (SSDs) which reflect the nature of the bond in question. Typically, the SSDs for the M-L data sets can be reduced to 0.04-0.05 A by these methods. This work is an extension to tables of bond lengths in organometallic compounds and coordination complexes published in 1989. The importance of the factors which affect M-L bond lengths for particular metal-ligand groups are discussed. From the case studies reported, an algorithm is proposed by which compilation of a library of molecular geometry for metal complexes may be automated. The points that need to be considered to produce such a molecular library from the data stored in the CSD are discussed. The development of such a library would allow users to retrieve chemically well-defined geometric data rapidly and accurately. This should be of use, for example, to crystallographers and molecular modelers. 相似文献
134.
We provide a rigorous theoretical basis for the artificial magnetic activity of metamaterials near resonances. Our approach is a renormalization-based scheme that authorizes a completely general theory. The major result is an explicit expression of the effective permeability, in terms of resonant frequencies. The theoretical results are checked numerically, and we give applications of our theory to left-handed media and to the solution of the Pokrovski-Efros paradox. 相似文献
135.
Phase-sensitive optical low-coherence reflectometry technique applied to the characterization of photonic crystal fiber properties 总被引:3,自引:0,他引:3
Palavicini C Jaouën Y Debarge G Kerrinckx E Quiquempois Y Douay M Lepers C Obaton AF Melin G 《Optics letters》2005,30(4):361-363
Localized measurements of group-velocity dispersion and birefringence of photonic crystal fibers are achieved with a phase-sensitive optical low-coherence reflectometry technique. This technique is efficient for fiber samples no longer than 1 m. Theoretical simulations are in good agreement with experimental results. As a result, the stress-induced birefringence proves to be at most 1 order of magnitude below the geometrical-shape birefringence. 相似文献
136.
Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina
Davis RA Mangalindan GC Bojo ZP Antemano RR Rodriguez NO Concepcion GP Samson SC de Guzman D Cruz LJ Tasdemir D Harper MK Feng X Carter GT Ireland CM 《The Journal of organic chemistry》2004,69(12):4170-4176
Microcionamides A (1) and B (2) have been isolated from the Philippine marine sponge Clathria (Thalysias) abietina. These new linear peptides are cyclized via a cystine moiety and have their C-terminus blocked by a 2-phenylethylenamine group. Their total structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Compound 1 was shown to slowly isomerize about the C-36/C-37 double bond when stored in DMSO. Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra. 相似文献
137.
Cattoën X Gornitzka H Bourissou D Bertrand G 《Journal of the American Chemical Society》2004,126(5):1342-1343
Despite the presence of a single amino substituent, an amino-anthryl-carbene was found to behave as a strong sigma-donor weak pi-acceptor ligand toward rhodium(I) fragments. 相似文献
138.
Bucher C Moutet JC Pécaut J Royal G Saint-Aman E Thomas F 《Inorganic chemistry》2004,43(13):3777-3779
The Cu(I) and Cu(II) complexes of the new 1,8-diferro-cenylmethyl-4,11-dimethyl-1,4,8,11-tetraazacyclotetra-decane ligand (denoted L) have been isolated and characterized by X-ray structure determination and electrochemical studies. The Cu(I) complex presents an unprecedented stability toward dioxygen. The two complexes adopt two energetically distinct and stable geometries, which differ mainly by the relative positioning of the substituents above or below the cyclam plane. Triggered by a copper-centered electron transfer, a fast and reversible motion of the noncoordinating subunits is obtained in homogeneous solution and in the solid state. 相似文献
139.
New classes of domains with explicit Bergman kernel 总被引:9,自引:1,他引:8
Roos GUY 《中国科学A辑(英文版)》2004,47(3):352-371
We introduce two classes of egg type domains, built on general bounded sym-metric domains, for which we obtain the Bergman kernel in explicit formulas. As an aux-iliary tool, we compute the integral of complex powers of the generic norm on a boundedsymmetric domains using the well-known integral of Selberg. This generalizes matrix in-tegrals of Hua and leads to a special polynomial with integer or half-integer coefficientsattached to each irreducible bounded symmetric domain. 相似文献
140.
Let F be a non-Archimedean local field with finite residue field. Let n be a positive integer, let G = GLn(F), and let D be a central F-division algebra of dimension n2. The Jacquet-Langlands correspondence gives a canonical bijection D from the set of equivalence classes of irreducible, smooth, essentially square-integrable representations of G to the set of equivalence classes of irreducible smooth representations of D![![times;. We give a necessary and sufficient condition, in terms of dim, for an irreducible smooth representation of D× to be of the form D, for an irreducible supercuspidal representation of G, thereby solving an old problem. This relies on the explicit classification of the irreducible smooth representations of G and the parallel classification of the irreducible representations of D×.This paper was written while the first-named author was visiting, and partly supported by, Université de Paris-Sud. At that time, the second-named author was enjoying the hospitality of the IHES, during a stay at the CNRS granted by Université de Paris-Sud; he would like to thank all those institutions. The work was also partially supported by EU network Arithmetical Algebraic Geometry.Mathematics Subject Classification (2000): 22E50 相似文献