C60Pd(Ph2PCH2PPh2)配合物的合成及光电性能研究

Fulerene complexe C60 Pd（ Ph2PCH2PPh2）was perpared by the method of ligand substitution via the reaction of C60 with Pd（Ph2PCH2PPh2）2 under condition of a nitrogen atmosphere and refluxing,and the title compound was appraised and characterized by methods of elemental analysis,FT-IR,UV-vis,XPS and XRD. The results showed that the structure of purposeful product was that the Ph2PCH2PPh2 took up two coordination sites of the central metal,and C60 took up another two sites in σ-π feeback pattern. The porperties on photoelectricity,redox and thermostability of the title complexe were studied. The results of studying on photoelectricity showed that the photovoltaic effect of（n+n）heterojunction electrode formed by C60Pd（Ph2PCH2PPh2）/ GaAs was supper,especially in the BQ/ H2Q redox couple,and the greatest value of photovoltaic potential was up to 174 mV. The photovoltaic performance of C60Pd（Ph2PCH2PPh2）/GaAs electrode at 1 μm for thickness of C60Pd（Ph2PCH2PPh2）film was the best.     

Controlling the pyridinium–zwitterionic ligand ratio on atomically precise gold nanoclusters allowing for eradicating Gram-positive drug-resistant bacteria and retaining biocompatibility

Infections caused by multidrug-resistant (MDR) bacteria are an increasing global healthcare concern. In this study, we developed a dual-ligand-functionalised Au₂₅(SR₁)_x(SR₂)_18−x-type gold nanocluster and determined its antibacterial activity against MDR bacterial strains. The pyridinium ligand (SR₁) provided bactericidal potency and the zwitterionic ligand (SR₂) enhanced the stability and biocompatibility. By optimising the ligand ratio, our gold nanocluster could effectively kill MDR Gram-positive bacteria via multiple antibacterial actions, including inducing bacterial aggregation, disrupting bacterial membrane integrity and potential, and generating reactive oxygen species. Moreover, combining the optimised gold nanocluster with common antibiotics could significantly enhance the antibacterial activity against MDR bacteria both in in vitro and animal models of skin infections. Furthermore, the fluorescence of the gold nanocluster at the second near-infrared (NIR-II) biological window allowed for the monitoring of its biodistribution and body clearance, which confirmed that the gold nanoclusters had good renal clearance and biocompatibility. This study provides a new strategy to combat the MDR challenge using multifunctional gold nanomaterials.

A NIR-II fluorescent Au₂₅ nanocluster capped with optimal dual functional ligands can effectively aggregate and kill Gram-positive drug-resistant bacteria while maintaining good biocompatibility.     

双晶格不匹配层状化合物的研究现状

双晶格不匹配层状化合物是一类具有两套次级晶格（两组晶胞常数）的复杂层状化合物,可分为氧化物和非氧化物两大类。对其结构和性能的研究是近些年刚刚引起人们关注的新领域。非氧化物类双晶格不匹配层状化合物的化学通式为[(MX)_n]_x(TX₂)_m,其中M=Sn, Pb, Bi及稀土元素等;X=S, Se等;n=1,3/2,2;x值在1.08-1.23之间; T为过渡金属元素;m=1, 2, 3等。双晶格不匹配层状氧化物的化学通式为A_α [(MO)_n]_x(TO₂)_m,其中A=Tl, Bi; M=Ca, Sr, Bi, Co; T=Co, Cr; α=0-0.41; n=1, 3/2, 2; m=1, 2等,x的值与化合物的组成有关。本文对该类化合物的分类、结构特点、合成方法以及性质等进行了总结,并对其研究的发展趋势进行了展望。     

Use of Fluorescent 2-AB to Explore the Bidirectional Transport Mechanism of Pseudostellaria heterophylla Polysaccharides across Caco-2 Cells

Polysaccharides are abundant in natural resources and perform numerous physiological functions. Polysaccharide structures often lack chromophore groups; thus, current analytical methods cannot distinguish polysaccharide metabolites in the body or polysaccharide prototypes in biological samples. Thus, the measurement of polysaccharides in blood, bodily fluid, and cell-culture medium is difficult. Our early-stage research resulted in the isolation of two homogeneous polysaccharides from Pseudostellaria heterophylla, PHP_0.5MSC-F and PHP_H-1-2, which have anti-hyperglycemia and insulin resistance improvement effects for type 2 diabetes. In this study, the reducing terminal sugars of PHP_0.5MSC-F and PHP_H-1-2 were labeled with 2-aminobenzamide (2-AB) to prepare novel fluorescent probes for HPLC-coupled fluorescence detection (HPLC-FLD). Quantitative analysis was performed in reference to T40, and the detection limit for PHP_0.5MSC-F was found to be 8.84 μg/mL with a linear range of 29.45–683.28 μg/mL. In reference to T70, the detection limit for PHP_H-1-2 was found to be 13.89 μg/mL with a linear range of 46.29–462.76 μg/mL. This method was used to measure the bidirectional transport of polysaccharides across caco-2 cells from apical to basolateral (AP→BL) or from basolateral to apical (BL→AP) directions and to evaluate the polysaccharide bioavailability. The drug absorption capacity was determined based on the apparent permeability coefficient (Papp), and the Papp values for the two polysaccharides were found to be greater than 1 × 10⁻⁶ cm/s, which suggests easy absorption. Regarding bidirectional transport, the AP→BL Papp values were greater than the BL→AP values; thus, PHP_0.5MSC-F and PHP_H-1-2 mainly underwent passive transference. The two membrane permeable polysaccharides were not P-gp efflux transporter substrates. The absorption mechanism of PHP_0.5MSC-F complies with passive diffusion under a concentration gradient, whereas PHP_H-1-2 mainly utilizes a clathrin-mediated endocytic pathway to enter caco-2 cells. This innovative HPLC-FLD method can help to track polysaccharide internalization in vitro and in vivo to facilitate cellular uptake and biodistribution exploration.     

基于相位载波复用的光纤周界安防系统及其实现方法

提出一种利用相位载波的调制解调技术实现白光干涉系统复用的周界安防新方法.该系统在单芯反馈式白光干涉系统的若干感应端,分别串接工作在不同频率的相位调制器.首先利用相位调制技术,将不同干涉子系统的感应端的触发信号从频域上分开;再使用相位解调技术,从同一干涉系统输出信号中获得相应于不同感应端的独立时域信号.实验中通过布设在现...     

钒基固溶体储氢材料弹性性质第一性原理研究

采用基于密度泛函理论的第一性原理赝势平面波方法,计算了（59Cr-41Ti）_100－xV_x（x=5,15,30,60,80,100）六种钒基储氢合金的晶格常数、弹性性质和电子态密度,计算结果与实验值符合较好.发现当x=60时的钒基合金具有较好弹性性质,杨氏模量为14930 GPa,切变模量为5442 GPa及体弹模量为19396 GPa.结合实验循环性能分析认为在吸放氢过程中合金已经发生塑性变形,弹性 关键词： 钒基固溶体 储氢合金材料 密度泛函理论 弹性性质     

Si(111)-(7×7)表面上Ge量子点的自组织生长

用扫描隧道显微镜研究了Si(111)(7×7)表面上Ge量子点的自组织生长.室温下用固相外延法在硅基底上沉积亚单层的Ge,然后在适当的温度下退火可以聚集形成有序的Ge量子点.由于Ge在Si(111)(7×7)表面选择性的吸附而形成有序的Ge量子点. 关键词： 锗 硅 扫描隧道显微镜 自组织生长     

仪器装置与实验技术小型矩形离子阱质谱仪的研制

研制的小型质谱仪以电子轰击源(EI)和矩形离子阱(RIT)质量分析器为核心部件,采用渗透阀控制的直接进样系统,高增益的电子倍增器用于离子检测,通过小信号放大系统对电子倍增器输出的弱电流再次放大,并输出电压信号,计算机上的NI数据采集卡和Labview操作软件对电压信号进行采集处理。由旋片机械泵和分子泵组成的真空系统可以形成10-5Pa的质谱工作环境。对研制的仪器进行了初步测试,得到了相应的质谱图,通过质量校正表明,结果令人满意。     

牛和猪肌肉组织中安乃近代谢物残留的液相色谱-串联质谱分析

建立了牛和猪肌肉组织中安乃近代谢残留物4-甲酰氨基安替比林、4-乙酰氨基安替比林、4-氨基安替比林和4-甲基氨基安替比林的高效液相色谱-串连质谱(LC-M/MS)测定法。肌肉组织样品均质后,采用硫酸钠提取液提取。过滤后,过C18固相萃取(SPE)柱净化,采用LC-MS/MS电喷雾电离(ESI),多反应监测(MRM)模式检测。4-甲酰氨基安替比林和4-乙酰氨基安替比林采用外标法定量,而4-甲基氨基安替比林和4-氨基安替比林则是以4-异丙基氨基安替比林作为内标物采用内标法进行定量;4-甲酰氨基安替比林和4-氨基安替比林的检出限为1.0μg/L;4-乙酰氨基安替比林和4-甲基氨基安替比林的检出限则为0.5μg/L;在添加浓度为5~200ng/g范围内,4-甲酰氨基安替比林的回收率为81.6%~94.0%;4-乙酰氨基安替比林的回收率为81.2%~90.2%;4-氨基安替比林的回收率为82%~101%;4-甲基氨基安替比林的回收率为78.5%~87.0%;相对标准偏差(RSD)均在7%以内。