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991.
Lan Yang Xiao He Zhiying Zeng Jiakun Tang Dongmei Qi Huijie Ma Hui Chen Xinghai Ning Xuli Feng 《Chemical science》2021,12(24):8394
Nucleus-targeted therapy holds great promise in cancer treatment; however, a lack of effective nucleus-specific delivery significantly limits its application potential. Here, we report a nucleus-targeted synergistic chemo-photodynamic therapy based on the self-assembly of chlorin e6 (Ce6) and doxorubicin (DOX) tuned by clickable dibenzocyclooctyne (DIBO) functionalized lysine (D-K) and subsequent reaction with crosslinkers. The assembled nanodrugs with high loading efficiency and long-term stability show enhanced cellular uptake and accumulation in the nucleus, resulting in greatly improved in vitro and in vivo chemo-photodynamic efficacy. Notably, D-K can promote the rapid self-assembly of Ce6 and DOX in aqueous solution, avoiding the introduction of organic solvents or tedious preparations. In addition, the introduction of the DIBO group can effectively expand the types of self-assembly material and enhance the self-assembly behaviour through a copper-free click reaction. Therefore, we present an effective nucleus-targeted combination drug delivery strategy, which has great potential in the treatment of many diseases.A highly efficient nucleus-targeted multi-drug delivery nanoplatform based on clickable amino acid tuned self-assembly of chlorin e6 and doxorubicin has been prepared for enhanced photodynamic therapy and chemotherapy. 相似文献
992.
In this paper, we established the general comparison prinples for IVP of impulsive differential equations with time variables, which strictly extend and improve the previous comparison results obtained by V.Lakes.et.al. and S.K.Kaul([3]–[7]). With the general comparison results, we constructed the monotone iterative sequences of solutions for IVP of such equations which converges the maximal and minimal solutions, repectively. 相似文献
993.
In this paper, by using an abstract continuous theorem of k-set contractive operator, the criteria is established for the existence, global attractivity of positive periodic solution of a neutral delay Logarithmic population model with multiple delays. The result improve the known ones in [S.P. Lu, W.G. Ge, Existence of positive periodic solutions for neutral Logarithmic population model with multiple delays, J. Comput. Appl. Math. 166 (2) (2004) 371-383]. 相似文献
994.
Rong Hu Jing Zhao Lian‐Wen Qi Ping Li Shan‐Lin Jing Hui‐Jun Li 《Rapid communications in mass spectrometry : RCM》2009,23(11):1619-1635
Aconite alkaloids from the roots of Aconitum carmichaeli (Fuzi, in Chinese) have been investigated by rapid‐resolution liquid chromatography coupled with time‐of‐flight mass spectrometry (TOFMS) in positive mode. With dynamic adjustment of the key role as fragmentor voltage in TOFMS, an efficient transmission of the ions was achieved to obtain the best sensitivity for providing the molecular formula for each analyte, and abundant fragment ions for structural information. Fifteen authentic standards isolated from Fuzi with various structures were first characterized by TOFMS, including diester‐diterpenoid alkaloids (DDAs), monoester‐diterpenoid alkaloids (MDAs), alkylol amine‐diterpenoid alkaloids (ADAs), veatchine‐type alkaloids and atisine‐type alkaloids. Fragmentation rules and key diagnostic fragment ions have been summarized, and possible pathways of fragmentation have been proposed. By accurate mass measurements within 5 ppm error for each ion, 30 C19‐diterpenoid alkaloids including 10 DDAs, 3 MDAs, 9 ADAs and 8 other type alkaloids, and 8 C20‐diterpenoid alkaloids including 4 veatchine‐type alkaloids and 4 atisine‐type alkaloids could be identified in a methanolic extract of Fuzi. Some isomers of aconite alkaloids were also differentiated. Based on the differences between their fragmentation pathways and special fragment ions, each type of aconite alkaloids was differentiated. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
995.
996.
In this paper, a n-species Lotka–Volterra competition system with delay and feedback controls is investigated. By means of the theory of comparison theorem and suitable Lyapunov functional, some sufficient conditions for the existence and uniqueness of almost positive periodic solutions of this system is obtained. 相似文献
997.
998.
运用广义Riccati变换给出时标上二阶非线性中立型动力学方程振动的充分条件,进一步研究了具扰动项的动力学方程解的性态.所得结论推广和改进了已知文献的部分结果. 相似文献
999.
1000.
Two-stage autoignition and combustion mode evolution in boundary layer flows above a cold flat plate
Huaibo Chen Mingyuan Tao Qi Yang Haiwen Ge Peng Zhao 《Proceedings of the Combustion Institute》2021,38(1):767-776
Boundary layers are omnipresent in fundamental kinetic experimental facilities and practical combustion engines, which can cause ambiguity and misleading results in kinetic target acquisition and even abnormal engine combustion. In this paper, using n-heptane as a representative large hydrocarbon fuel exhibiting pronounced low-temperature chemistry (LTC), two-dimensional numerical simulation is conducted to resolve the transient autoignition phenomena affected by a boundary layer. We focus on the ignition characteristics and the subsequent combustion mode evolution of a hot combustible mixture flowing over a colder flat plate in an isobaric environment. For cases with autoignition occurring within the boundary layer, similarity is observed in the first-stage ignition as manifested by a constant temperature at all locations. The first-stage ignition is found to be rarely affected by heat and radical loss within the boundary layer. While for the main ignition event, an obvious dependence of ignition process on boundary layer thickness is identified, where the thermal-chemical process exhibits similarity at locations with similar boundary layer thickness, and the main ignition tends to first occur within the boundary layer at the domain end and generates a C-shape reaction front. It is found that sequential spontaneous autoignition is the dominant subsequent combustion mode at high-pressure conditions. At low to intermediate pressures, auto-ignition assisted flame propagation is nevertheless the dominant mode for combustion evolution. This research identifies novel features of autoignition and the subsequent combustion mode evolution affected by a cold, fully developed boundary layer, and provides useful guidance to the interpretation of abnormal combustion and combustion mode evolution in boundary layer flows. 相似文献