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31.
Griffiths G. Keegan E. Young E. Wotherspoon A. Palmer T. Lu K. Davis J. Alexander J. Jolly L. Nevers N. Delaunay F. Collins J. M. Dimayuga I. Bergeron A. Samuleev P. Dai Z. Holliday K. Robel M. Knight K. 《Journal of Radioanalytical and Nuclear Chemistry》2018,315(2):365-378
Journal of Radioanalytical and Nuclear Chemistry - Physical characterization is one of the most broad and important categories of techniques to apply in a nuclear forensic examination. Physical... 相似文献
32.
Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells 下载免费PDF全文
Dr. Simon J. Allison Dr. David Cooke Francesca S. Davidson Prof. Paul I. P. Elliott Dr. Robert A. Faulkner Hollie B. S. Griffiths Owen J. Harper Omar Hussain Prof. P. Jane Owen‐Lynch Prof. Roger M. Phillips Prof. Craig R. Rice Samantha L. Shepherd Dr. Richard T. Wheelhouse 《Angewandte Chemie (International ed. in English)》2018,57(31):9799-9804
The ligands L1 and L2 both form separable dinuclear double‐stranded helicate and mesocate complexes with RuII. In contrast to clinically approved platinates, the helicate isomer of [Ru2( L1 )2]4+ was preferentially cytotoxic to isogenic cells (HCT116 p53?/?), which lack the critical tumour suppressor gene. The mesocate isomer shows the reverse selectivity, with the achiral isomer being preferentially cytotoxic towards HCT116 p53+/+. Other structurally similar RuII‐containing dinuclear complexes showed very little cytotoxic activity. This study demonstrates that alterations in ligand or isomer can have profound effects on cytotoxicity towards cancer cells of different p53 status and suggests that selectivity can be “tuned” to either genotype. In the search for compounds that can target difficult‐to‐treat tumours that lack the p53 tumour suppressor gene, [Ru2( L1 )2]4+ is a promising compound for further development. 相似文献
33.
Jonsson AP Bergman T Jörnvall H Griffiths WJ 《Rapid communications in mass spectrometry : RCM》2001,15(9):713-720
An understanding of the gas-phase dissociation of protonated peptides within the mass spectrometer is essential for automated high-throughput protein identification. In this communication we describe a facile cleavage of the Gln-Gly peptide bond under low-collisional energy conditions. A variety of synthetic peptides have been analysed where key amino acids have been substituted within the sequence PQGPPQQGGR, which is a consensus repeat present in the tryptic peptides of acidic proline-rich protein 1 (PRP-1). The collision-induced dissociation spectra obtained from the PRP-1 tryptic peptides and the synthetic peptides indicate that facile Gln-Gly cleavage occurs when an X-Gln-Gly-Y sequence is present in a peptide, where X is any amino acid and Y any amino acid other than Gly. 相似文献
34.
Bond AD Griffiths J Rawson JM Hulliger J 《Chemical communications (Cambridge, England)》2001,(23):2488-2489
Non-centrosymmetric structures are promoted through the use of perfluoroaromatics containing structure-directing CN...X (X = Br, I) supramolecular synthons. 相似文献
35.
Raymond J. Abraham Lee Griffiths Philip Loftus 《Journal of computational chemistry》1982,3(3):407-416
Alternative methods of estimating atomic charges in haloalkanes are presented, derived from quantum mechanical and classical treatments. A scheme based on a breakdown of the transmission of charge by polar atoms into one-bond, two-bond, and three-bond additive contributions is given, in which the one-bond effect is proportional to the difference in the electronegativities of the bonded atoms, and the two- and three-bond effects functions of the atomic electronegativity and polarizability. Suitable developments of the basic scheme, including an iterative self-consistent process, give calculated dipole moments for a variety of haloalkanes in good agreement with the observed values. The atomic charges obtained by this scheme are compared with other estimates of these charges. They are similar to those derived from a simple LCAO –MO scheme but differ from those obtained by population analysis of more refined quantum mechanical calculations. 相似文献
36.
Jennifer E. Mihalick William P. Griffiths III James E. Muten Travis A. Olson John B. Hein 《Journal of solution chemistry》1999,28(8):1019-1030
Solution calorimetry was used to determine enthalpies and stability constants for binding of lead(II) or cadmium(II) by galacturonic acid and several monosaccharides in aqueous solution. New values for enthalpies of solution in water are reported for galacturonic acid and maltose monohydrate. The interaction of water solvent with the reactants is the largest factor in the binding process. 相似文献
37.
Several aspects of localized defects in the Frenkel-Kontorova, classicalXY chain and analogous models with a finite range of interactions are discussed from a general point of view. Precise definitions are given for defect phase shifts (charges) and for creation, pinning, and interaction energies. Corresponding definitions are also provided for interfaces (localized regions separating two phases). For the nearest-neighbor Frenkel-Kontorova model, the various defect energies are related to areas enclosed by contours joining heteroclinic points of the area-preserving map generated by the conditions of mechanical equilibrium. 相似文献
38.
D. F. Griffiths 《国际流体数值方法杂志》1981,1(4):323-346
Explicit basis functions are constructed for 9-node biquadratic velocity fields which guarantee that a weak form of the continuity equation is satisfied. The corresponding pressure approximations are either piecewise constant, piecewise linear or piecewise bilinear. These results are extended to give bases for bilinear velocity/piecewise constant pressure elements and also to some three-dimensional brick elements. 相似文献
39.
Ohne Zusammenfassung 相似文献
40.
The familiar Newman-Penrose formalism, in which the curvature of space-time is represented in terms of spin coefficients, is here extended to include the possibility of an asymmetric connection. It is hoped that this approach will be useful in dealing with certain problems in Einstein-Cartan theory, and also in other theories of gravitation that include torsion. 相似文献