Observation of shot-noise-induced asymmetry in the Coulomb blockaded Josephson junction

We have investigated the influence of shot noise on the IV curves of a single mesoscopic Josephson junction. We observe a linear enhancement of zero-bias conductance of the Josephson junction with increasing shot-noise power. Moreover, the IV curves become increasingly asymmetric. Our analysis on the asymmetry shows that the Coulomb blockade of Cooper pairs is strongly influenced by the non-Gaussian character of the shot noise.     

Aglairubine: Structure Revision of a Chemotaxonomically Interesting Bisamide in Aglaia (Meliaceae)

Summary.  The bisamide aglairubine was isolated from different Aglaia species. The original structure was revised on the basis of FDMS and 2D-NMR data. Since all isolates were obtained from species belonging to the section Amoora of the genus Aglaia, aglairubine might serve as a taxonomic marker. Received July 3, 2001. Accepted July 12, 2001     

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution

Aspercyclide A (1) is a biaryl ether containing 11-membered macrocyclic natural product antagonist of the human IgE-FcεRI protein-protein interaction (PPI); a key interaction in the signal transduction pathway for allergic disorders such as asthma. Herein we report a novel approach to the synthesis of the C19 methyl ether of aspercyclide A, employing a Pd(0)-catalysed, fluorous-tagged alkenylgermane/arylbromide macrocyclisation (germyl-Stille reaction) as the key step, and evaluation of both enantiomers of this compound via ELISA following optical resolution by CSP-HPLC. A crystal structure for germyl hydride 27 is also reported.