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61.
62.
A new series of 6,8-dibromo-2-(4-chlorophenyl)quinazolin-4(3H)-one derivatives VI–XIII were synthesized. Their chemical structures were confirmed by spectral and elemental analysis. The cytotoxic effect of the newly synthesized compounds was tested in vitro against human breast cancer cell line (MCF-7). Most of the tested compounds have shown promising cytotoxic activity. Compounds X and XIIIb exerted a powerful cytotoxic effect against MCF-7 with a very low IC50 (0.0015 and 0.0047 µmol/ml), while compounds VI, VII, VIII, XIIb, XI, XIIIc and IX exerted a moderate cytotoxic effect (IC50 0.01523, 0.0213, 0.031, 0.0478, 0.049, 0.068 and 0.079 µmol/ml respectively), compared to doxorubicin (0.0025 µmol/ml). Exploring their apoptotic effect; interestingly,all compounds activated apoptotic cascade in MCF-7. Compounds VI, XIIIb, XIIb, XI, XIIa, VII, V and VIII showed potent effect even much more than doxorubicin by 12.87–5.91 folds, while compounds XIIIc, IX, XIIIa, XIIc and X showed moderate increase in CASP3 activity by 4.96–3.22 folds relative to untreated cells more or less similar to doxorubicin (5.57 folds). 相似文献
63.
Journal of Structural Chemistry - By the interaction of Er(NO3)3 with a buffer Hchc/Na(chc) solution (Hchc is cyclohexanecarboxylic acid) Er3(chc)9(Hchc)0.5 complex (1) is obtained. The structure... 相似文献
64.
Daria V. Chernysheva Igor N. Leontyev Marina V. Avramenko Nikolay V. Lyanguzov Tatyana I. Grebenyuk Nina V. Smirnova 《Mendeleev Communications》2021,31(2):160-162
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65.
Obliquely propagating altra-low-frequency dust-electromagnetic waves in a self-gravitating, warm, magnetized, two fluid dusty
plasma system have been investigated. Two special cases, namely, dust-Alfvén mode propagating parallel to the external magnetic
field and dustmagnetosonic mode propagating perpendicular to the external magnetic field have also been considered. It has
been shown that effects of self-gravitational field, dust fluid temperature, and obliqueness significantly modify the dispersion
properties of these ultra-low-frequency dust-electromagnetic modes. It is also found that in parallel propagating dust-Alfvén
mode these effects play no role, but in obliquely propagating dust-Alfvén mode or perpendicular propagating dust-magnetosonic
mode the effect of self-gravitational field plays destabilizing role whereas the effect of dust/ion fluid temperature plays
stabilizing role. 相似文献
66.
S.N. Grebenyuk 《Journal of Applied Mathematics and Mechanics》2014,78(2):187-191
A relation is proposed for determining of the shear modulus of a fibrous composite material with a transversely isotropic matrix and a fibre as a function of the elastic constants of the matrix and the fibre as well as the volume fraction of each of them in the composite material. The isotropy planes of the matrix and fibre coincide and are perpendicular to the fibre axis. Two boundary value problems are solved in order to obtain the required relation: the problem of the longitudinal shear of a transversely isotropic solid cylinder that simulates the fibrous composite material and the problem of the combined longitudinal shear of a hollow and solid cylinder that simulate the matrix material and the fibre material respectively. Calculations using the proposed formula are compared with the available experimental data. 相似文献
67.
A big problem in low-coherence interference microscopy is the degradation of the coherence signal caused by shift of the angular and temporal spectrum gates. It limits the depth of field in confocal optical coherence microscopy and degrades images of sample inner structure in most interference microscopy techniques. To overcome this problem we propose numerical correction of the coherence gate in application to full-field swept-source interference microscopy. The proposed technique allows three-dimensional sample imaging without mechanical movement of the microscope components and is also capable of determining separately the geometrical thickness and the refractive index of the sample layers, when the sample contains a transversal pattern. The applicability of the proposed technique is verified with numerical simulation. 相似文献
68.
We propose a method for quantitatively taking into account nonselective absorption for systems in which the vapor phase contains
a single molecular form: sodium and potassium chlorides and iodides. We identified the absorption bands using modern quantum
chemistry methods. We have demonstrated good agreement between the experimental data and the calculations. We have tested
the correctness of the method we developed for the example of determining known silicon and iron contents in potassium chloride
and sodium iodide. Differences between the results obtained and the true elemental contents were random.
__________
Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 73, No. 3, pp. 397–400, May–June, 2006. 相似文献
69.
It is shown how one can transform scalar first-order ordinarydifferential equations which admit non-local symmetries of theexponential type to integrable equations admitting canonicalexponential non-local symmetries. As examples we invoke theAbel equation of the second kind, the Riccati equation and naturalgeneralizations of these. Moreover, our method describes howa double reduction of order for a second-order ordinary differentialequation which admits a two-dimensional Lie algebra of generatorsof point symmetries can be affected if the second-order equationis first reduced in order once by a symmetry which does notspan an ideal of the two-dimensional Lie algebra. 相似文献
70.