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排序方式: 共有129条查询结果,搜索用时 31 毫秒
21.
ChemMatrix, a poly(ethylene glycol)-based support for the solid-phase synthesis of complex peptides 总被引:5,自引:0,他引:5
García-Martín F Quintanar-Audelo M García-Ramos Y Cruz LJ Gravel C Furic R Côté S Tulla-Puche J Albericio F 《Journal of combinatorial chemistry》2006,8(2):213-220
CM (ChemMatrix) resin is a new, totally poly(ethylene glycol) (PEG)-based resin, made exclusively from primary ether bonds and, therefore, highly chemically stable. It exhibits good loading and is user-friendly because of its free-flowing form upon drying. It performs excellently for the preparation of hydrophobic, highly structured, and poly-Arg peptides, as compared to polystyrene (PS) resins. In the most striking example, stepwise solid-phase assembly of the highly complex beta-amyloid (1-42) peptide resulted in a crude material of 91% purity. In contrast, literature procedures using PS or PEG-PS-based resins for this peptide required convergent approaches, additional time-consuming steps, or both. In addition to the difficulties of its synthesis, characterization of the beta-amyloid (1-42) peptide as a monomer is also a challenge, and methods for characterization by HPLC and MALDI-TOF have also been developed. 相似文献
22.
A detailed hypothesis for the biogenesis of haouamines is reported herein, supported by experiments headed towards biomimetic synthesis of these compounds. 相似文献
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24.
This paper studies the learning process in an ant colony optimization algorithm designed to solve the problem of ordering cars on an assembly line (car-sequencing problem). This problem has been shown to be NP-hard and evokes a great deal of interest among practitioners. Learning in an ant algorithm is achieved by using an artificial pheromone trail, which is a central element of this metaheuristic. Many versions of the algorithm are found in literature, the main distinction among them being the management of the pheromone trail. Nevertheless, few of them seek to perfect learning by modifying the internal structure of the trail. In this paper, a new pheromone trail structure is proposed that is specifically adapted to the type of constraints in the car-sequencing problem. The quality of the results obtained when solving three sets of benchmark problems is superior to that of the best solutions found in literature and shows the efficiency of the specialized trail. 相似文献
25.
J Alliot E Gravel F Pillon DA Buisson M Nicolas E Doris 《Chemical communications (Cambridge, England)》2012,48(65):8111-8113
A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid. 相似文献
26.
Lok-Hang Yan Flore Dagorn Edmond Gravel Blandine Séon-Méniel Erwan Poupon 《Tetrahedron》2012,68(31):6276-6283
Lycopodium alkaloids are unique (and often impressive in terms of structures) polycyclic alkaloids that attract great interest from a biological point of view and that also provide ideal targets for total synthesis. Propylpiperidine units closely related to pelletierine are involved in the biosynthesis of these alkaloids. Therefore, stable pelletierine-like compounds, especially a (R)-phenylglycinol-based oxazolopiperidine analog, were prepared and their reactivity investigated. The compounds described in this work expand the tool-box of small building blocks in the piperidine series and pelletierine analogs and could be suitable for the synthesis of Lycopodium alkaloids following biosynthetically inspired strategies. 相似文献
27.
Aaron Luntala Nsakanda Wilson L. Price Moustapha Diaby Marc Gravel 《European Journal of Operational Research》2007
The entropy-based measure has been used in previous works to compute the population diversity in solving the cell formation problem with the genetic algorithm. Population diversity is crucial to the genetic algorithm’s ability to continue fruitful exploration as it may be used in choosing an initial population, in defining a stopping criterion, in evaluating the population convergence, and in making the search more efficient throughout the selection of crossover operators or the adjustment of various control parameters (e.g., crossover or mutation rate, population size). We show in this note that, when a non-ordinal chromosome representation corresponding to the allocation of machines to cells is used, the current way of measuring the population diversity is inaccurate. Consequently, it leads to wrong conclusions when, at various iterations, carrying out fruitful exploration or an efficient search of the solution space is guided by the perceived population diversity degree. An alternative approach based on computing the distance and the similarity between chromosomes is discussed. 相似文献
28.
We review systems in E(2) that are separable in Cartesian coordinates and admit a third-order integral both in quantum mechanics and in classical mechanics. Differences and similarities between those two cases are illustrated by numerous examples. Many of these superintegrable systems are new, and a relation is seen between superintegrable potentials and Painlevé transcendents. 相似文献
29.
Bulten HJ Anthony PL Arnold RG Arrington J Beise EJ Belz E van Bibber K Bosted PE van den Brand JF Chapman MS Coulter KP Dietrich FS Ent R Epstein M Filippone BW Gao H Gearhart RA Geesaman DF Hansen J Holt RJ Jackson HE Jones CE Keppel CE Kinney E Kuhn SE Lee K Lorenzon W Lung A Makins NC Margaziotis DJ McKeown RD Milner RG Mueller B Napolitano J Nelson J O'Neill TG Papavassiliou V Petratos GG Potterveld DH Rock SE Spengos M Szalata ZM Tao LH White JL Zeidman B 《Physical review letters》1995,74(24):4775-4778
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