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51.
Alejandra Salemo Graciela Buldain Isabel A. Perillo 《Journal of heterocyclic chemistry》2001,38(4):849-852
1H NMR spectra of a series of 1,2 and 1,3‐diarylimidazolidines are analyzed and correlated with their conformational features. Results were interpreted on the basis of chemical shifts and coupling constants of hydrogen atoms and confirmed by ID nOe difference experiments. 1,3‐Diarylimidazolidines ( 1–7 ) show a fast inversion of the N‐aryl nitrogen in all studied cases. 1,2‐Diaryl‐3‐methyl (or benzyl) imidazolidines ( 8–13 ) display a preferential conformation with a transoid orientation of N3 and C2 substituents. 相似文献
52.
Jaime Baeza Juanita Freer Graciela Palma 《Monatshefte für Chemie / Chemical Monthly》1984,115(11):1369-1371
The oxidative addition of benzenethiol to indene in the presence of ovoalbumin produces only one isomer on the surface of the protein,trans-anti-2-phenylsulfinyl-1-indanol. This reaction may be considered as a biomimetic model of detoxification of certain hydrocarbons by the liver.
Stereoselektive oxydative Anlagerung von Thiophenol an Inden in Gegenwart von Ovoalbumin (Kurze Mitteilung)
Zusammenfassung Durch die oxydative Anlagerung von Thiophenol an Inden in Gegenwart von Ovoalbumin bildet sich nur ein Isomer an der Oberfläche des Proteins, dastrans-anti-2-Phenylsulfinyl-1-Indanol. Diese Reaktion kann als ein biomimetisches Modell der Entgiftung von gewissen Kohlenwasserstoffen durch die Leber betrachtet werden.相似文献
53.
54.
Graciela Chichilnisky 《Journal of Mathematical Analysis and Applications》1977,61(2):504-520
A problem of existence and characterization of solutions of optimal growth models in many sector economies is studied. The social utility to be optimized is a generalized form of a preference depending additively on consumption at the different dates of the planning period. The optimization is restricted to a set of admissible growth paths defined by production-investment-consumption relations described by a system of differential equations. Sufficient conditions are given for existence of a solution in a Hilbert space of paths, without convexity assumptions on either the utilities or the technology, using techniques of nonlinear functional analysis. A characterization is given of the utilities which are continuous with respect to the Hilbert space norm. Under convexity assumptions a characterization is also given of optimal and efficient solutions by competitive prices. 相似文献
55.
We present here a scenario, based on a low reheating temperature T(R)<100 MeV at the end of (the last episode of) inflation, in which the coupling of sterile neutrinos to active neutrinos can be as large as experimental bounds permit (thus making this neutrino "visible" in future experiments). In previous models this coupling was forced to be very small to prevent a cosmological overabundance of sterile neutrinos. Here the abundance depends on how low the reheating temperature is. For example, the sterile neutrino required by the Liquid Scintillator Neutrino Detector result may not have any cosmological problem within our scenario. 相似文献
56.
We show that direct dark-matter detection experiments can distinguish between pointlike and nonpointlike dark-matter candidates. The shape of the nuclear recoil-energy spectrum from pointlike dark-matter particles, e.g., neutralinos, is determined by the velocity distribution of dark matter in the galactic halo and by nuclear form factors. Typical cross sections of nonpointlike dark matter, for example, Q-balls, have a new form factor, which decreases rapidly with the recoil energy. A signal from nonpointlike dark matter is expected to peak near the experimental threshold and to fall off rapidly at higher energies. 相似文献
57.
Moglioni AG Muray E Castillo JA Alvarez-Larena A Moltrasio GY Branchadell V Ortuño RM 《The Journal of organic chemistry》2002,67(8):2402-2410
The reactions between N-benzyl- and N-methylhydroxylamine and chiral enoate esters, derived from D-glyceraldehyde and (-)-verbenone, respectively, have been investigated. Theoretical calculations show that the most favorable mechanism involves the concerted cycloaddition of the hydroxylamine to the substrate. This result is in good agreement with the stereospecificity observed when the trisubstituted olefins are used. The open-chain adducts have been isolated when the processes are carried out at low temperatures and for short reaction times. These compounds evolve to the corresponding isoxazolidinones on standing at room temperature or under acid catalysis. The high pi-facial diastereoselection has been rationalized on the basis of steric effects induced by the dioxolane ring for D-glyceraldehyde derivatives or by the cyclobutane gem-dimethyl substitution for esters prepared from (-)-verbenone. As an application of these reactions, new beta-amino acids have been synthesized in a highly efficient and stereocontrolled manner. 相似文献
58.
Graciela Salete Centenaro Myriam Salas-Mellado Carla Pires Irineu Batista Maria L. Nunes Carlos Prentice 《Applied biochemistry and biotechnology》2014,172(6):2877-2893
In this work, chicken and fish peptides were obtained using the proteolytic enzymes α-Chymotrypsin and Flavourzyme. The muscle was hydrolyzed for 4 h, and the resulting peptides were evaluated. Hydrolysates were produced from Argentine croaker (Umbrina canosai) with a degree of hydrolysis (DH) of 25.9 and 27.6 % and from chicken (Gallus domesticus) with DH of 17.8 and 20.6 % for Flavourzyme and α-Chymotrypsin, respectively. Membrane ultrafiltration was used to separate fish and chicken hydrolysates from Flavourzyme and α-Chymotrypsin based on molecular weight cutoff of >1,000, <1,000 and >500, and <500 Da, to produce fractions (F1,000, F1,000–500, and F500) with antioxidant activity. Fish hydrolysates produced with Flavourzyme (FHF) and α-Chymotrypsin showed 60.8 and 50.9 % of peptides with a molecular weight of <3 kDa in its composition, respectively. To chicken hydrolysates produced with Flavourzyme and α-Chymotrypsin (CHC) was observed 83 and 92.4 % of peptides with a molecular weight of <3 kDa. The fraction that showed, in general, higher antioxidant potential was F1,000 from FHF. When added 40 mg/mL of FHF and CHC, 93 and 80 % of lipid oxidation in ground beef homogenates was inhibited, respectively. The composition of amino acids indicated higher amino acids hydrophobic content and amino acids containing sulfuric residues for FHF, which showed antioxidant potential. 相似文献
59.
Renata leite Tavares Maria Helena Araújo de Vasconcelos Maria Letícia da Veiga Dutra Aline Barbosa DOliveira Marcos dos Santos Lima Mirian Graciela da Silva Stiebbe Salvadori Ramon de Alencar Pereira Adriano Francisco Alves Yuri Mangueira do Nascimento Josean Fechine Tavares Omar Guzman-Quevedo Jailane de Souza Aquino 《Molecules (Basel, Switzerland)》2020,25(23)
This study evaluated the effect of Mucuna pruriens (MP) administration on neuroinflammation and behavioral and murinometric parameters in obese rats. Proximate composition, oligosaccharide and phenolic compound profile of MP were determined. Wistar adult male rats were randomized into healthy (HG) and obese group (OG). The HG consumed a control chow diet while OG consumed a cafeteria diet for eight weeks. Then, they were subdivided into: Healthy (HG); Healthy with MP administration (HGMP); Obese (OG); Obese with MP administration (OGMP), with the consumption of the respective diets remaining for another eight weeks, in addition to gavage with MP extract to supplemented groups (750 mg/kg weight). MP presented a composition rich in proteins and phenolic compounds, especially catechin, in addition to 1-kestose and levodopa. Supplementation reduced food intake, body weight, and thoracic and abdominal circumferences in obese rats. MP showed anxiolytic and antidepressant effects and reduced morphological damage and expression of interleukin 6 in the hippocampus of obese rats. MP treatment showed satietogenic, slimming, anxiolytic and antidepressant effects, besides to minimizing hippocampal neuroinflammation in obese rats. Our results demonstrated the potential anti-obesity of MP which are probably related to the high content of bioactive compounds present in this plant extract. 相似文献
60.
Luz Arancibia Mariana Naspi Graciela Pucci Maricel Rodriguez Florencia Di Salvo 《Acta Crystallographica. Section C, Structural Chemistry》2020,76(9):914-920
The terpenoid (?)‐Istanbulin A is a natural product isolated from Senecio filaginoides DC, one of the 270 species of Senecio (Asteraceae) which occurs in Argentina. The structure and absolute configuration of this compound [9a‐hydroxy‐3,4a,5‐trimethyl‐4a,6,7,8a,9,9a‐hexahydro‐4H,5H‐naphtho[2,3‐b]‐furan‐2,8‐dione or (4S,5R,8R,10S)‐1‐oxo‐8β‐hydroxy‐10βH‐eremophil‐7(11)‐en‐12,8β‐olide, C15H20O4] were determined by single‐crystal X‐ray diffraction studies. It proved to be a sesquiterpene lactone showing an eremophilanolide skeleton whose chirality is described as 4S,5R,8R,10S. Structural results were also in agreement with the one‐ and two‐dimensional (1D and 2D) NMR and HR–ESI–MS data, and other complementary spectroscopic information. In addition, (?)‐Istanbulin A is a polymorph of the previously reported form of (?)‐Istanbulin A, form I; thus, the title compound is denoted form II or polymorph II. Structural data and a literature search allowed the chirality of Istanbulin A to be revisited. The antimicrobial and antifungal activities of (?)‐Istanbulin A, form II, were evaluated in order to establish a reference for future comparisons and applications related to specific crystal forms of Istanbulins. 相似文献