A biosensor for monitoring formaldehyde using a new lipophilic tetrathiafulvalene-tetracyanoquinodimethane salt and a polyurethane membrane

The fabrication and application of an end-column amperometric detection (AD) system with a carbon electrode for capillary-column liquid chromatography (CLC) were described. This new amperometric detector showed good sensitivity and stability in detecting the thiocompounds and other analytes with CLC. In order to obtain the better separation and detection performance for analytes, several operational parameters had been investigated: the working potentials, pH and flow rate. Under the optimum conditions, the method could effectively separate and determine cysteine (Cys), glutathione (GSH), dopamine (DA) and 6-thiopurine (6-TP). Good repeatability for retention time was obtained with a relative standard deviation (R.S.D.) value of 0.5%. The linear range covered over three orders of magnitude and the limits of detection were 8 fmol for cysteine, 20 fmol for glutathione, 8 fmol for dopamine and 20 fmol for 6-thiopurine. This method was successfully applied in determination of urinary sample with characteristics of simplicity, high sensitivity and good repeatability.     

Study of the peak effect phenomenon in single crystals of 2H-NbSe2

The weakly pinned single crystals of the hexagonal 2H-NbSe₂ compound have emerged as prototypes for determining and characterizing the phase boundaries of the possible order-disorder transformations in the vortex matter. We present here a status report based on the ac and dc magnetization measurements of the peak effect phenomenon in three crystals of 2H-NbSe₂, in which the critical current densities vary over two orders of magnitude. We sketch the generic vortex phase diagram of a weakly pinned superconductor, which also utilizes theoretical proposals. We also establish the connection between the metastability effects and pinning.     

Students' understanding of the notion of function in dynamic geometry environments

To make optimal use of computational environments, one must understand how students interact with the environments and how students' mathematical thinking is reflected and affected by their use of the environments. Similarly, to make sense of research on students' thinking and learning, one must understand how the environments and contexts used in the research may affect the conclusions one derives.The research on students' learning of functions has approached the topic in terms of symbols and graphs (see, for example, Leinhardt et al. (1990) for a review of work up to that point; Harel and Dubinsky (1992) for a collection of research; and Dugdale et. al. (1995), for some recent thinking about implications for curriculum reform using technology). Dynamic geometry environments (DGEs) like Cabri Geometry or Geometer's Sketchpad, offer us an opportunity to get a new perspective on these old and important issues. DGEs let students build geometrical constructions and then drag certain objects around the screen in a continuous manner while observing how the entire construction responds dynamically. In this way DGEs model functional relationships that are not specified by symbols or represented by graphs.Based on interviews with undergraduate mathematics majors, this paper presents preliminary observations that confirm some old results and raise some new questions about students' notions of function.     

Experimental studies of gyrotron electron beam systems

In order to provide electron beams of powerful gyrotrons, magnetron-injection guns operating in the regime of the temperature limited current are used. The electron beam quality and gyrotron performances are defined both by the cathode emission processes and the processes occurring in the electron beam during its formation and transportation. The results of measurements of the energy spectrum and velocity spread of the gyrotron electron beam in different regimes are given. Experimental data on the parameter of efficient emission inhomogeneity for different regimes are presented, as well as the dependencies of electron beam parameters on efficient inhomogeneity of the cathode     

Combined prostate diffusion tensor imaging and dynamic contrast enhanced MRI at 3T — quantitative correlation with biopsy

The purpose of this work was to compare diagnostic accuracy of Diffusion Tensor Imaging (DTI), dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) and their combination in diagnosing prostate cancer. Twenty-five patients with clinical suspicion of prostate cancer underwent MRI, prior to transrectal ultrasound-guided biopsies. MRI data were correlated to biopsy results. Logistic regression models were constructed for the DTI parameters, DCE MRI parameters, and their combination. The areas under the receiver operator characteristic curves (AUC) were compared between the models. The nonparametric Wilcoxon signed rank test was used for statistical analysis. The sensitivity and specificity values were respectively 81% (74–87%) and 85% (79–90%) for DTI and 63% (55–70%) and 90% (85–94%) for DCE. The combination “DTI or DCE MRI” had 100% (97–100%) sensitivity and 77% (69–83%) specificity, while “DTI and DCE MRI” had 44% (37–52%) sensitivity and 98% (94–100%) specificity. The AUC for DTI+DCE parameters was significantly higher than that for either DTI (0.96 vs. 0.92, P=.0143) or DCE MRI parameters (0.96 vs. 0.87, P=.00187) alone. In conclusion, the combination of DTI and DCE MRI has significantly better accuracy in prostate cancer diagnosis than either technique alone.     

Feedback between node and network dynamics can produce real-world network properties

Real-world networks are characterized by common features, including among others a scale-free degree distribution, a high clustering coefficient and a short typical distance between nodes. These properties are usually explained by the dynamics of edge and node addition and deletion.     

Fabrication of LIGA masks for microfluidic analytical systems

Preliminary results of fabrication and testing of LIGA mask samples for deep x-ray lithography in the spectral range of 3.5–13.5 keV are presented. The mask fabrication method is based on direct mask patterning with minimum element sizes of ≥ 10 μm by a synchrotron radiation x-ray microbeam. Such a method does not require an intermediate mask, which significantly simplifies fabrication and reduces the laboriousness and cost of LIGA masks.