Nonlinear dynamics of a time-delayed epidemic model with two explicit aware classes,saturated incidences,and treatment

Nonlinear Dynamics - Whenever a disease emerges, awareness in susceptibles prompts them to take preventive measures, which influence individuals’ behaviors. Therefore, we present and analyze...     

First Dual Responsive “Turn-On” and “Ratiometric” AIEgen Probe for Selective Detection of Hydrazine Both in Solution and the Vapour Phase

A new dual responsive “turn-on” and “ratiometric” aggregation-induced emission luminogen (AIEgen) 3-formyl-5-(piperidin-1-yl)biphenyl-4-carbonitrile 6 a (FPBC 6 a ) for selective detection of hydrazine in solution as well as in vapour phase is described. At a low concentration of 2.5 μm , the probe FPBC 6 a is non-fluorescent (turn-off) but remarkably lights up (turn-on with blue emission) in the presence of hydrazine solution (0.25–25 μm ). Interestingly, at higher concentrations, the nanoaggregates of FPBC 6 a (>25 μm , 99 % HEPES in DMSO) displayed ratiometric response in the presence of hydrazine with a remarkable hypsochromic shift from the green (500–550 nm) to blue regions (440–480 nm). Furthermore, a real application of FPBC 6 a was successfully demonstrated through the detection and visualization of hydrazine in live cervical cancer cells as well as using portable test strips.     

Recent advances in continuous flow synthesis of heterocycles

In the current scenario, flow chemistry is emerging as a significant technology in the field of organic synthesis. This miniaturized protocol including microreactors facilitates excellent heat transfer, low solvent wastage, lesser reaction time, a safer environment for reagent handling and appreciable yields of desired products. Thus, this “enabling technology” has a great scope in the synthesis and preparation of a variety of heterocycles that require toxic reagents as starting materials. This review discusses the recent advances (2020–2021) in continuous flow strategy for synthesis and derivatization of variety of heterocyclic entities, of different ring size, using different approaches. This also highlights the advantages of different combined techniques like Microwave assisted heating, electrochemical flow cell, LED light source, NMR and FT-IR analysis, etc., that enables utilization of various mechanisms and real-time monitoring of reactions leading to improved results.

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Classical and Bayesian inference in two parameter exponential distribution with randomly censored data

This paper deal with the classical and Bayesian estimation for two parameter exponential distribution having scale and location parameters with randomly censored data. The censoring time is also assumed to follow a two parameter exponential distribution with different scale but same location parameter. The main stress is on the location parameter in this paper. This parameter has not yet been studied with random censoring in literature. Fitting and using exponential distribution on the range \((0, \infty )\), specially when the minimum observation in the data set is significantly large, will give estimates far from accurate. First we obtain the maximum likelihood estimates of the unknown parameters with their variances and asymptotic confidence intervals. Some other classical methods of estimation such as method of moment, L-moments and least squares are also employed. Next, we discuss the Bayesian estimation of the unknown parameters using Gibbs sampling procedures under generalized entropy loss function with inverted gamma priors and Highest Posterior Density credible intervals. We also consider some reliability and experimental characteristics and their estimates. A Monte Carlo simulation study is performed to compare the proposed estimates. Two real data examples are given to illustrate the importance of the location parameter.     

Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules

A new series of benzocycloheptene amino vinyl bromide derivatives (9a-9m) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative (9a) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.     

Large neighborhood search for LNG inventory routing

Liquefied Natural Gas (LNG) is steadily becoming a common mode for commercializing natural gas. Due to the capital intensive nature of LNG projects, the optimal design of LNG supply chains is extremely important from a profitability perspective. Motivated by the need for a model that can assist in the design analysis of LNG supply chains, we address an LNG inventory routing problem where optimized ship schedules have to be developed for an LNG project. In this paper, we present an arc-flow formulation based on the MIP model of Song and Furman (Comput. Oper. Res., 2010). We also present a set of construction and improvement heuristics to solve this model efficiently. The heuristics are evaluated based on a set of realistic test instances that are very large relative to the problem instances seen in recent literature related to this problem. Extensive computational results indicate that the proposed methods are computationally efficient in finding optimal or near optimal solutions and are substantially faster than state-of-the-art commercial optimization software.     

Localization and antilocalization in InSb and InAs antidot lattices

We report on the observation of localization, antilocalization and Altshuler–Aronov–Spivak (AAS) oscillations in antidot lattices patterned on high-mobility InSb/InAlSb and InAs/AlGaSb heterostructures. In addition, the antidot lattices display ballistic commensurability features. The strength of the localization peak in InSb antidot lattices decreases exponentially with temperature, with a high characteristic temperature of 25 K between 0.4 and 50 K. Analysis of the AAS oscillations enables the extraction of phase and spin coherence lengths in InAs.     

Enhanced colorless and broadcast capable symmetrical 10-Gbps bidirectional transmission in WDM-PON using RSOA and EAM

Here we proposed a novel architecture of wavelength division multiplexed-passive optical network (WDM-PON) in which the downlink unicast data, broadcast data and uplink unicast data transmission is possible with the symmetric data rate of 10 Gbps. At remote node (RN) cyclic wavelength routing property of array waveguide grating (AWG) and power splitting capacity of power splitter is used in the architecture so that broadcast channel can be overlaid on downlink unicast channels. At ONU carriers sent from central office (CO) is reused for upstream data transmission with the help of integration of a reflective semiconductor amplifier (RSOA) and an electro-absorption modulator (EAM) so there is no need of extra laser sources at ONUs which makes them colorless. EAM can be operated at very high speed; a modulation bandwidth of tens of GHz can be achieved. Broadcast channel causes a limited interference with downlink and uplink unicast channels so it does not affect the system performance. Since each channel has different wavelength so NRZ data is used which eliminates expensive DPSK receivers and detection becomes very easy. Simulation is performed with all channels having data rate of 10 Gbps having acceptable performance.     

Synthesis, structural characterisation and biological activity of novel N-(ferrocenylmethyl)benzene-carboxamide derivatives

A series of N-(ferrocenylmethyl)benzene-carboxamide derivatives (4a-f) have been synthesised by coupling ferrocenylmethyl amine 3 with benzoic acid and various substituted fluorobenzoic acids using the standard 1,3-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. All compounds were fully characterised using a combination of ¹H NMR, ¹³C NMR, ¹⁹F NMR, DEPT-135, ¹H-¹H COSY and ¹H-¹³C COSY (HMQC) spectroscopy and electrospray ionisation mass spectrometry (ESI-MS). The compounds 4a, 4d, 4e and 4f exhibited cytotoxic effects on the MDA-MB-435-S-F breast cancer cell line. Single crystal X-ray crystallographic data for 4d is also presented.     

Preparation of sodium dimolybdate by the pyrolysis of sodium oxomolybdenum (VI) oxalate

Thermal studies on various oxalato complexes have been of immense interest as they yield finely divided, highly reactive oxides which are usually obtained at a much lower temperature than that required in the conventional method of preparation, i.e., heating a mixture of two or more constituents [1]. A survey of the literature reveals that the compounds having the general formula A₂[Mo₂O₅(C₂O₄)₂(H₂O)₂], where A = K⁺, NH⁺₄[2] and A = Cs⁺ [3], have been prepared and their thermal decomposition is studied, but no such information is available regarding the preparation and characterisation of Na₂[Mo₂O₅(C₂O₄)₂(H₂O)₂] (SMO), which forms the subject of study of this paper. Sodium dimolybdate (Na₂Mo₂O₇), the decomposition product of SMO, is obtained at 280°C, a temperature much lower than that required in the conventional method of preparation of heating a mixture of Na₂MoO₄ and MoO₃ [4].