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31.
Elena Genova Maura Apollonio Giuliana Decorti Alessandra Tesser Alberto Tommasini Gabriele Stocco 《Molecules (Basel, Switzerland)》2021,26(12)
Interferonopathies are rare genetic conditions defined by systemic inflammatory episodes caused by innate immune system activation in the absence of pathogens. Currently, no targeted drugs are authorized for clinical use in these diseases. In this work, we studied the contribution of sulforaphane (SFN), a cruciferous-derived bioactive molecule, in the modulation of interferon-driven inflammation in an immortalized human hepatocytes (IHH) line and in two healthy volunteers, focusing on STING, a key-component player in interferon pathway, interferon signature modulation, and GSTM1 expression and genotype, which contributes to SFN metabolism and excretion. In vitro, SFN exposure reduced STING expression as well as interferon signature in the presence of the pro-inflammatory stimulus cGAMP (cGAMP 3 h vs. SFN+cGAMP 3 h p value < 0.0001; cGAMP 6 h vs. SFN+cGAMP 6 h p < 0.001, one way ANOVA), restoring STING expression to the level of unstimulated cells. In preliminary experiments on healthy volunteers, no appreciable variations in interferon signature were identified after SFN assumption, while only in one of them, presenting the GSTM1 wild type genotype related to reduced SFN excretion, could a downregulation of STING be recorded. This study confirmed that SFN inhibits STING-mediated inflammation and interferon-stimulated genes expression in vitro. However, only a trend towards the downregulation of STING could be reproduced in vivo. Results obtained have to be confirmed in a larger group of healthy individuals and in patients with type I interferonopathies to define if the assumption of SFN could be useful as supportive therapy. 相似文献
32.
A feasibility study of X‐ray phase‐contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron 下载免费PDF全文
Yakov I. Nesterets Timur E. Gureyev Sheridan C. Mayo Andrew W. Stevenson Darren Thompson Jeremy M. C. Brown Marcus J. Kitchen Konstantin M. Pavlov Darren Lockie Francesco Brun Giuliana Tromba 《Journal of synchrotron radiation》2015,22(6):1509-1523
Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low‐dose high‐sensitivity three‐dimensional mammographic phase‐contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X‐ray energy, source size, detector resolution, sample‐to‐detector distance, scanning and data processing strategies in the case of propagation‐based phase‐contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast‐tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 µm, revealed the presence of propagation‐based phase contrast and demonstrated significant improvement of the quality of phase‐contrast CT imaging compared with conventional (absorption‐based) CT, at medically acceptable radiation doses. 相似文献
33.
Massimo Tosolini Teresa Gianferrara Giuliana Mion Luca Dovigo Fabrizio Mancin 《Supramolecular chemistry》2020,32(2):91-105
ABSTRACTA new family of conjugates between the Hoechst minor groove binder and the TACN metal ion ligand connected through hydrophobic alkyl or more hydrophilic oxyethyl linkers of different length has been prepared. The linkers are connected to the convex side of the Hoechst skeleton thus forcing the TACN ligand to exit the minor groove and interact with the phosphate backbone of DNA. The conjugates preserve the binding mode of Hoechst with an affinity influenced by the nature of the linker, the more hydrophobic being the more efficient. Coordination of Cu(II) or Zn(II) poorly affect these parameters. Nevertheless, the Zn(II) complex bearing a C6 linear alkyl linker induced a modest but reproducible acceleration of the hydrolytic cleavage of DNA which can be ascribed to the ability of the conjugate to deliver the hydrolytic subunit close to the DNA phosphodiester bonds. 相似文献
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Nancy C. Forero-Martinez Robinson Cortes-Huerto Antonio Benedetto Pietro Ballone 《Molecules (Basel, Switzerland)》2022,27(5)
The thermodynamics, structures, and applications of thermoresponsive systems, consisting primarily of water solutions of organic salts, are reviewed. The focus is on organic salts of low melting temperatures, belonging to the ionic liquid (IL) family. The thermo-responsiveness is represented by a temperature driven transition between a homogeneous liquid state and a biphasic state, comprising an IL-rich phase and a solvent-rich phase, divided by a relatively sharp interface. Demixing occurs either with decreasing temperatures, developing from an upper critical solution temperature (UCST), or, less often, with increasing temperatures, arising from a lower critical solution temperature (LCST). In the former case, the enthalpy and entropy of mixing are both positive, and enthalpy prevails at low T. In the latter case, the enthalpy and entropy of mixing are both negative, and entropy drives the demixing with increasing T. Experiments and computer simulations highlight the contiguity of these phase separations with the nanoscale inhomogeneity (nanostructuring), displayed by several ILs and IL solutions. Current applications in extraction, separation, and catalysis are briefly reviewed. Moreover, future applications in forward osmosis desalination, low-enthalpy thermal storage, and water harvesting from the atmosphere are discussed in more detail. 相似文献
37.
Unimodular waveforms x are constructed on the integers with the property that the autocorrelation of x is one at the origin and zero elsewhere. There are three different constructions: exponentials of the form e2 pi na q,e^{2 \pi i n^\alpha \theta}, sequences taken from roots of unity, and sequences constructed from the elements of real Hadamard matrices. The first is
expected and elementary and the second is based on the construction of Wiener. The third is the most intricate and is really
one of a family of distinct but structurally similar waveforms. A natural error estimate problem is posed for the last construction.
The analytic solution is not as useful as the simulations because of the inherent counting problems in the construction. 相似文献
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39.
Giuliana Palmieri 《Annali di Matematica Pura ed Applicata》1980,126(1):117-147
Summary We study boundary value problems in variational form for nonlinear elliptic operators in the case the nonlinearity is not of polynomial type. We give some examples of applications of abstract theorems for homogeneous problems obtained by other authors (e.g. Donaldson, Grossez) to homogeneous «intermediate» and «mixed» problems. Furthermore we prove some existence theorems for non homogeneous problems.
Lavoro eseguito nell'ambito del G.N.A.F.A. del C.N.R. 相似文献
Lavoro eseguito nell'ambito del G.N.A.F.A. del C.N.R. 相似文献
40.