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排序方式: 共有266条查询结果,搜索用时 31 毫秒
261.
Markus Leimbacher Dr. Yixin Zhang Dr. Luca Mannocci Michael Stravs Dr. Tim Geppert Dr. Jörg Scheuermann Prof. Gisbert Schneider Prof. Dario Neri 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(25):7729-7737
Libraries of chemical compounds individually coupled to encoding DNA tags (DNA‐encoded chemical libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high‐quality DNA‐encoded chemical library comprising 30 000 drug‐like compounds; this was screened in 170 different affinity capture experiments. High‐throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic analysis of selection strategies and statistically robust identification of binding molecules. Selections performed against the tumor‐associated antigen carbonic anhydrase IX (CA IX) and the pro‐inflammatory cytokine interleukin‐2 (IL‐2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL‐2 was confirmed by molecular docking. Our findings suggest that DNA‐encoded chemical libraries allow the facile identification of drug‐like ligands principally to any protein of choice, including molecules capable of disrupting high‐affinity protein–protein interactions. 相似文献
262.
Gisbert?RiessEmail author Hans-Werner?Schmidt 《Monatshefte für Chemie / Chemical Monthly》2006,137(7):935-941
Summary. A series of polyureas were synthesized from amino terminated polydimethylsiloxane oligomers, diamine comonomers, and various
diisocyanates. These polymers were characterized by nuclear magnetic resonance (NMR), infrared (IR) spectroscopy, and size
exclusion chromatography (SEC). The gelation behavior in silicone fluids such as dimethylcyclosiloxanes was investigated.
The influence of the structure of the hard segment on the gelation properties was evaluated. 相似文献
263.
Gil García MD Martínez Galera M Barranco Martínez D Gisbert Gallego J 《Journal of chromatography. A》2006,1103(2):271-277
An on-line pre-concentration method for the analysis of five benzoylureas (diflubenzuron, triflumuron, hexaflumuron, lufenuron and flufenoxuron) in ground water samples was evaluated using two C(18) columns, and fluorescence detection after photochemical induced fluorescence (PIF) post-column derivatization. The trace enrichment was carried out with 35 mL of ground water modified with 15 mL of MeOH on a 50 mm x 4.6 mm I.D. first enrichment column (C-1) packed with 5 microm Hypersil Elite C(18). Retention properties of pesticides and humic acids usually contained in ground water were studied on C-1 at concentration levels ranging between 0.04 and 14.00 microg/L in water samples. The results obtained in this study show that the pesticides are pre-concentrated in the first short column while the humic acids contained in the ground water samples are eluted to waste. Pesticides recoveries ranged between 92.3 and 109.5%. The methodology proposed was used to determine benzoylureas in ground water samples at levels lower than 0.1 microg/L (maximum levels established by the European Union). 相似文献
264.
265.
Oskar Nuyken Hubertus Krner Gisbert Rieß Saehoon Oh Stefan Ingrisch 《Macromolecular Symposia》1996,101(1):29-42
Scope and limitation of the vinyl ether polymerization initiated by NR4ClO4(KClO4;LiClO4)/CH3CHI-OR was discussed. Besides isobutyl vinyl ether (IBVE), N-vinylcarbazole (NVC) and 2-chloroethyl vinyl ether (CEVE) were initiated by NR4ClO4/CH3CHI-OR. These polymerizations exhibited the characteristics of a living polymerization. However, in order to observe narrow molar mass distribution NVC was initiated with CH3CHI-OR, without salts. Block copolymers were synthesized by the method of sequential monomer addition (NVC, IBVE, CEVE). The PCEVE segment was modified by nucleophilic substitution, which allowed the synthesis of amphiphilic block copolymers. 相似文献
266.