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151.
Fuad O. Abdullah Faiq H. S. Hussain Abdullah Sh. Sardar Gianluca Gilardoni Solveig Tosi Giovanni Vidari 《Molecules (Basel, Switzerland)》2022,27(18)
Herbal medicines are still widely practiced in Kurdistan Region-Iraq, especially by people living in villages on mountainous regions. Among plants belonging to the genus Teucrium (family Lamiaceae), which are commonly employed in the Kurdish traditional medicine, we have analyzed, for the first time, the methanol and aqueous methanol extracts of T. parviflorum aerial parts. The plant is mainly used by Kurds to treat jaundice, liver disorders and stomachache. We aimed to determine the phytochemical profile of the extracts and the structures of the main components, so to provide a scientific rationale for the ancient use of the plant in the ethno-pharmacological field. TLC analysis of the two extracts on silica gel and reversed phase TLC plates, using different visualization systems, indicated similar contents and the presence of phenolics, flavonoids, terpenoids and sugars. The chlorophyll-free extracts exhibited weak/no antimicrobial activities against a panel of bacteria (MICs = 800–1600 µg/mL) and fungal strains (MICs ≥ 5 mg/mL). At the concentration of 600 µg/mL, the methanol extract showed moderate antiproliferative effects against A549 and MCF-7 cancer cell lines in the MTS assay. Moreover, both extracts exhibited a significant dose-dependent free radical scavenging action against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical (EC50 = 62.11 and 44.25 μg/mL, respectively). In a phytochemical study, a high phenolic content (77.08 and 81.47 mg GAE/g dry extract, respectively) was found in both extracts by the Folin–Ciocalteu assay. Medium pressure liquid chromatographic (MPLC) separation of the methanol extract on a reversed phase cartridge eluted with a gradient of MeOH in H2O, afforded two bioactive iridoid glucosides, harpagide (1) and 8-O-acetylharpagide (2). The structures of 1 and 2 were established by spectral data, chemical reactions, and comparison with the literature. Interestingly, significant amounts of hepatotoxic furano neo-clerodane diterpenoids, commonly occurring in Teucrium species, were not detected in the extract. The wide range of biological activities reported in the literature for compounds 1 and 2 and the significant antiradical effects of the extracts give scientific support to the traditional use in Iraqi Kurdistan of T. parviflorum aerial parts for the preparation of herbal remedies. 相似文献
152.
Dattilo D Armelao L Maggini M Fois G Mistura G 《Langmuir : the ACS journal of surfaces and colloids》2006,22(21):8764-8769
We report the immobilization of a fulleropyrrolidine, bearing a dec-9-ynyl functionality, on silicon surfaces through a thermal hydrosilylation protocol. Contact angle measurements on porous silicon (PS) surfaces reveal an unusual dependence of the angle with the PS roughness that apparently contradicts Wenzel's formula. This result has been explained by an extension of Wenzel's model in which the critical angle, which discriminates between the hydrophilic/hydrophobic character of a solid material, is substantially reduced below 90 degrees by surface roughness. 相似文献
153.
Zhou Q Henderson WA Appetecchi GB Montanino M Passerini S 《The journal of physical chemistry. B》2008,112(43):13577-13580
Two ionic liquids based upon N-alkyl-N-methylpyrrolidinium cations (PY(1R)(+)) (R=3 for propyl or 4 for butyl) and the bis(fluorosulfonyl)imide (FSI(-)), N(SO2F)2(-), anion have been extensively characterized. The ionic conductivity and viscosity of these materials are found to be among the highest and lowest, respectively, reported for aprotic ionic liquids. Both ionic liquids crystallize readily on cooling and undergo several solid-solid phase transitions on heating prior to melting. PY13FSI and PY14FSI are found to melt at -9 and -18 degrees C, respectively. The thermal stability of PY13FSI and PY14FSI is notably lower than for the analogous salts with the bis(trifluoromethanesulfonyl)imide (TFSI(-)), N(SO2CF3)2(-), anion. Both ionic liquids have a relatively wide electrochemical stability window of approximately 5 V. 相似文献
154.
This investigation represents a first attempt to gain a quantitative estimate of the effects of the anions sulfate, citrate, acetate, chloride and thiocyanate on the thermodynamic stability (DeltaG degrees) of a model globular protein in ice at -15 degrees C. The method, based on guanidinium chloride denaturation of the azurin mutant C112S from Pseudomonas aeruginosa, distinguishes between the effects of cooling to subfreezing temperatures from those induced specifically by the formation of a solid ice phase. The results confirm that, both in liquid and frozen states, kosmotropes (sulfate, citrate and acetate) increase significantly protein stability, relative to chloride, whereas the chaotrope thiocyanate decreases it. Throughout, their stabilizing efficacy was found to rank according to the Hofmeister series, sulfate>citrate>acetate>chloride>thiocyanate, although the magnitude of Delta(DeltaG degrees) exhibited a distinct sensitivity among the anions to low temperature and to ice formation. In the liquid state, lowering the temperature from +20 to -15 degreesC weakens considerably the stabilizing efficacy of the organic anions citrate and acetate. Among the anions sulfate stands out as the only strong stabilizer at subfreezing temperatures while SCN- becomes an even stronger denaturant. Freezing of the solution in the presence the "neutral" salt NaCl destabilizes the protein, DeltaG degrees progressively decreasing up to 3-4 kcal/mol as the fraction of liquid water in equilibrium with ice (VL) is reduced to less than 1%. Kosmotropes do attenuate the decrease in protein stability in ice although in the case of citrate and acetate, their efficacy diminishes sharply as the liquid fraction shrinks to below 2.7%. On the contrary, sulfate is remarkable for it maintains constantly high the stability of azurin in liquid and frozen solutions, down to the smallest VL (0.5%) examined. Throughout, the reduction in DeltaG degrees caused by the solidification of water correlates with the decrease in the denaturant m value, an indirect indication that protein-ice interactions generally lead to partial unfolding of the native state. It is proposed that binding of the kosmotropes to the ice interface may inhibit protein adsorption to the solid phase and thereby counter the ice perturbation. 相似文献
155.
Giovanni C. Petrucelli Mauricio A. Meirinho Thais R. Macedo Claudio Airoldi 《Thermochimica Acta》2006,450(1-2):16-21
Synthesized hydrated lamellar acidic crystalline magadiite (H2Si14O29·2H2O) nanocompound was used as host for intercalation of polar n-alkylmonoamine molecules of the general formula H3C(CH2)nNH2 (n = 1–6) in aqueous solution. The original interlayer distance (d) of 1500 pm, determined by X-ray powder diffraction patterns, increases after intercalation. The values correlated with the number of aliphatic amine carbon (nc) atoms: d = [(1312 ± 11) + (21 ± 2)]nc. The amount of intercalated amines (Ns), decreased as nc increased: Ns = [(5.82 ± 0.04) − (0.45 ± 0.01)]nc. The acidic layered nanocompound was calorimetrically titrated with the amines and the thermodynamic data gave exothermic values for all guest molecules, as shown by the correlation: ΔintH = −[(24.45 ± 0.49) − (1.91 ± 0.10)]nc and d = [(1576 ± 16) − (10.8 ± 1.0)]ΔintH. The negative values of the Gibbs energies and the positive entropies also presented the correlations: ΔintG = −[(22.8 ± 0.2) − (0.2 ± 0.1)]nc and ΔintS = [(6 ± 1) + (5 ± 1)]nc, respectively. 相似文献
156.
Benedetti M Fanizzi FP Maresca L Natile G 《Chemical communications (Cambridge, England)》2006,(10):1118-1120
Zeise's anion in strongly basic hydroxylated solvents undergoes unprecedented nucleophilic addition of OR- (R = H, Me, Et) to the eta2-ethene giving trans-[PtCl2(eta1-C2H4OR)(OR)]2- which readily reacts with bidentate nitrogen donors N-N to give Cl- and OR- substitution and formation of [PtCl(CH2CH2OR)(N-N)]. Protonolysis of this stable organometallic species offers a versatile route to cationic [PtCl(eta2-C2H4)(N-N)]+ complexes. 相似文献
157.
Giovanni Zocchi 《Chemphyschem》2006,7(3):555-560
One common strategy for the detection of biomolecules is labeling either the target itself or an antibody that binds to it. Herein, a different approach, based on detecting the conformational change of a probe molecule induced by binding of the target is discussed. That is, what is being detected is not the presence of the target or the probe, but the conformational change of the probe. Recently, a single-molecule sensor has been developed that exploits this mechanism to detect hybridization of a single DNA oligomer to a DNA probe, as well as specific binding of a single protein to a DNA probe. Biomolecular recognition often involves large conformational changes of the molecules involved, and therefore this strategy may be applicable to other assays. 相似文献
158.
Molecular modeling techniques have been used to investigate the interaction of L-lysine in aqueous medium with silanol and methyl sites onto quartz substrates. The substrate effect has been studied for partially hydrophilic surfaces formed by silanol and methyl groups with a ratio of 1:5 and hydrophobic fully methylated surfaces. Molecular dynamics and static calculations indicate that L-lysine does not show any significant interaction with fully methylated surfaces, while its interaction with hydroxylated/methylated surfaces is dominated by electrostatic and H-bond terms. Accordingly, on fully methylated surfaces there is no preferential orientation of L-lysine with respect to the surface, while for hydroxylated/methylated surfaces the L-lysine-surface interaction mainly depends on the molecular orientation, with a preferred geometry involving the ammonium group pointing toward the silanol site. The structure of water shells around L-lysine molecules was shown to be strongly affected by the relative hydrophilic/hydrophobic character of the surfaces. In particular, the order is almost completely lost for partially hydrophilic surfaces, while well-defined hydration shells around L-lysine are obtained for hydrophobic surfaces. 相似文献
159.
Chemical conversions within the cages of doped sol-gel porous oxides take place with unique advantages over reactions in solution as the glassy matrix has tremendous effects on the reactivity of the entrapped molecules. The chemical properties of sol-gel materials can be tailored in an immense range of values and chemists are increasingly achieving control on reactions taking place within these matrices, including crucially important photovoltaics. Highlighting recent major advancements, we show in this tutorial review how this is actually taking place. 相似文献
160.
Sandro Calogero Paolo Ganis Valerio Peruzzo Giuseppe Tagliavini Giovanni Valle 《Journal of organometallic chemistry》1981,220(1):11-20
The structures of tricyclohexyltin fluoride (I), bromide (II) and iodide (III) have been determined by X-ray analysis. Compound I crystallizes in the space group P21/m with a = 10.422(6), b = 17.238(9), c = 5.769(3) Å, β = 104.6(1)° and Z = 2. Compounds II and III crystallize in the space group Pcmn with a = 10.427(6), b = 16.914(9), c = 11.366(6) Å, Z = 4; and a = 10.400(6), b = 16.900(10), c = 11.400(4) Å, Z = 4, respectively. All three structures consist of discrete tetrahedral (cyclo-C6H11)3SnX units.The temperature dependence of the Mössbauer resonance areas has been examined in order to obtain information about the relationship between chemical structure and lattice dynamics. 相似文献