A versatile polycation scaffold that can easily be modified with targeting ligands has been designed, synthesized, and characterized. A series of galactose‐containing polymers has been produced to demonstrate the ease of modification of this polynucleotide delivery vehicle motif via the click reaction and to study how various structural modifications affect recognition by ASGPr on hepatocytes. A small library of structures was created where DCS and alkyl spacer length between the targeting group and the polymer backbone was varied. The novel polymer scaffold described proves to be a valuable tool for understanding structure/activity relationships of complexes made with receptor‐targeted polymers.
The paper addresses restaurant revenue management from both a strategic and an operational point of view. Strategic decisions in restaurants are mainly related to defining the most profitable combination of tables that will constitute the restaurant. We propose new formulations of the so-called “Tables Mix Problem” by taking into account several features of the real setting. We compare the proposed models in a computational study showing that restaurants, with the capacity of managing tables as renewable resources and of combining different-sized tables, can improve expected revenue performances. Operational decisions are mainly concerned with the more profitable assignment of tables to customers. Indeed, the “Parties Mix Problem” consists of deciding on accepting or denying a booking request from different groups of customers, with the aim of maximizing the total expected revenue. A dynamic formulation of the “Parties Mix Problem” is presented together with a linear programming approximation, whose solutions can be used to define capacity control policies based on booking limits and bid prices. Computational results compare the proposed policies and show that they lead to higher revenues than the traditional strategies used to support decision makers. 相似文献
In this paper the question of finding infinitely many solutions to the problem −Δu+a(x)u=|u|p−2u, in RN, u∈H1(RN), is considered when N≥2, p∈(2,2N/(N−2)), and the potential a(x) is a positive function which is not required to enjoy symmetry properties. Assuming that a(x) satisfies a suitable “slow decay at infinity” condition and, moreover, that its graph has some “dips”, we prove that the problem admits either infinitely many nodal solutions or infinitely many constant sign solutions. The proof method is purely variational and allows to describe the shape of the solutions. 相似文献
The doubly diastereoselective conjugate addition of the antipodes of lithium N-benzyl-N-(α-methylbenzyl)amide to a range of enantiopure N-enoyl oxazolidin-2-ones has been used as a mechanistic probe to determine that the reactive conformation is the anti-s-cis form. The β-amino carbonyl products resulting from these conjugate addition reactions are useful templates for further elaboration into an α,β,α-pseudotripeptide. 相似文献
The influence of the sulfinyl group as a chiral auxiliary in the stereoselective addition of oxiranyllithiums to (S)-2-p-tolylsulfinylbenzaldehyde has been studied. All reactions evolve with retention of configuration at the starting lithiated carbon. Completely stereoselective additions have been observed when configurations at sulfur and the lithiated carbon are different (matched pair), whereas variable dr's values (ranging between 52:48 and >99:<1%) when they are identical (mismatched pair). 相似文献