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排序方式: 共有107条查询结果,搜索用时 15 毫秒
51.
Facchinei Francisco Lampariello Lorenzo Scutari Gesualdo 《Mathematical Programming》2017,164(1-2):55-90
Mathematical Programming - We propose a general feasible method for nonsmooth, nonconvex constrained optimization problems. The algorithm is based on the (inexact) solution of a sequence of... 相似文献
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Francisco Facchinei Jong-Shi Pang Gesualdo Scutari Lorenzo Lampariello 《Mathematical Programming》2014,145(1-2):59-96
We consider centralized and distributed algorithms for the numerical solution of a hemivariational inequality (HVI) where the feasible set is given by the intersection of a closed convex set with the solution set of a lower-level monotone variational inequality (VI). The algorithms consist of a main loop wherein a sequence of one-level, strongly monotone HVIs are solved that involve the penalization of the non-VI constraint and a combination of proximal and Tikhonov regularization to handle the lower-level VI constraints. Minimization problems, possibly with nonconvex objective functions, over implicitly defined VI constraints are discussed in detail. The methods developed in the paper are then used to successfully solve a new power control problem in ad-hoc networks. 相似文献
54.
Gómez GE Mundo MR Craig PO Delfino JM 《Journal of the American Society for Mass Spectrometry》2012,23(1):30-42
Much knowledge into protein folding, ligand binding, and complex formation can be derived from the examination of the nature
and size of the accessible surface area (SASA) of the polypeptide chain, a key parameter in protein science not directly measurable
in an experimental fashion. To this end, an ideal chemical approach should aim at exerting solvent mimicry and achieving minimal
selectivity to probe the protein surface regardless of its chemical nature. The choice of the photoreagent diazirine to fulfill
these goals arises from its size comparable to water and from being a convenient source of the extremely reactive methylene
carbene (:CH2). The ensuing methylation depends primarily on the solvent accessibility of the polypeptide chain, turning it into a valuable
signal to address experimentally the measurement of SASA in proteins. The superb sensitivity and high resolution of modern
mass spectrometry techniques allows us to derive a quantitative signal proportional to the extent of modification (EM) of
the sample. Thus, diazirine labeling coupled to electrospray mass spectrometry (ESI-MS) detection can shed light on conformational
features of the native as well as non-native states, not easily addressable by other methods. Enzymatic fragmentation of the
polypeptide chain at the level of small peptides allows us to locate the covalent tag along the amino acid sequence, therefore
enabling the construction of a map of solvent accessibility. Moreover, by subsequent MS/MS analysis of peptides, we demonstrate
here the feasibility of attaining amino acid resolution in defining the target sites. 相似文献
55.
Scicchitano P Carbonara S Ricci G Mandurino C Locorotondo M Bulzis G Gesualdo M Zito A Carbonara R Dentamaro I Riccioni G Ciccone MM 《Molecules (Basel, Switzerland)》2012,17(4):4225-4235
Hyperpolarization and Cyclic Nucleotide (HCN) -gated channels represent the molecular correlates of the "funny" pacemaker current (I(f)), a current activated by hyperpolarization and considered able to influence the sinus node function in generating cardiac impulses. HCN channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. This channel family comprises four members: HCN1-4, but there is a general agreement to consider HCN4 as the main isoform able to control heart rate. This review aims to summarize advanced insights into the structure, function and cellular regulation of HCN channels in order to better understand the role of such channels in regulating heart rate and heart function in normal and pathological conditions. Therefore, we evaluated the possible therapeutic application of the selective HCN channels blockers in heart rate control. 相似文献
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Lauro Tomio A. Delfino T. Frederico M. R. Hadizadeh M. T. Yamashita 《Few-Body Systems》2013,54(1-4):213-216
The fixed-slope correlation between tetramer and trimer binding energies, observed by Tjon in the context of nuclear physics, is mainly a manifestation of the dominance of the two-nucleon force in the nuclear potential, which makes the four-body scale on the order of the three-body one. In a more general four-boson case, the correlation between tetramer and trimer binding energies has a non-fixed slope, which expresses the dependence on the new scale. The associated scaling function generates a family of Tjon lines. This conclusion relies on a recent study with weakly-bound four identical bosons, within a renormalized zero-range Faddeev-Yakubovsky formalism. 相似文献
60.
Casoli T Stefano GD Fattoretti P Solazzi M Delfino A Biagini G Bertoni-Freddari C 《Micron (Oxford, England : 1993)》2003,34(8):415-422
The growth-associated protein GAP-43 is a presynaptic membrane phosphoprotein that is expressed at high levels during development and axonal growth. To evaluate the cellular distribution of GAP-43 mRNA in the hippocampus and cerebellum of adult rats we applied in situ hybridization (ISH) as well as direct and indirect in situ RT-PCR using biotin as a reporter molecule. ISH resulted in a positive signal in most cerebellar granular cells and in 30% of hippocampal CA3 neurons. Direct in situ RT-PCR yielded cells with strong signals in every region investigated, with elevated background levels most likely related to incorporation of labeled nucleotides into non-specific amplicons through internal priming and DNA repair activity. Indirect in situ RT-PCR turned out to be the best approach for detecting GAP-43 mRNA positive cells. Cerebellar cells exhibiting a positive signal for GAP-43 mRNA were of the granular cell type (98%). Hippocampal neurons with a positive reaction for GAP-43 mRNA included all the neuron groups analyzed, namely CA1 (99%) and CA3 pyramidal cells (94%) and dentate gyrus granule cells (92%). Dentate gyrus granule cells have not tested positive for GAP-43 mRNA detection by molecular morphology analysis. These data show that in normal rats GAP-43 mRNA is present in different cell populations of hippocampal formation, supporting the role of this protein in the ongoing processes of synaptic plasticity. 相似文献