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91.
Moore DT Oomens J Eyler JR von Helden G Meijer G Dunbar RC 《Journal of the American Chemical Society》2005,127(19):7243-7254
Infrared spectra were recorded for a series of gas-phase Cr+ complexes using infrared multiphoton dissociation (IRMPD) in a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The functionalized aromatic ligands (acetophenone, anisole, aniline, and dimethyl aniline) offer a choice of either aromatic ring-pi or n-donor-base binding sites. Use of the FELIX free electron laser light source allowed convenient, rapid scanning of the chemically informative wavelength range from approximately 500 to 1800 cm(-1), which in many cases characterized the preferred site of metal binding, as well as the electronic spin state of the complex. Mono-complex ions, Cr+(ligand), for anisole, aniline, and dimethyl aniline and bis-complex ions, Cr+(ligand)(2), for anisole, aniline, and acetophenone were produced by ligand attachment to laser-desorbed Cr+ ions in the FT-ICR cell. The photodissociation yields plotted as a function of wavelength were interpreted as approximations to the infrared absorption spectra and were compared with computed spectra of different possible geometries and spin states. Clear-cut diagnostic features in the spectra of the acetophenone, anisole, and aniline complexes showed the sites of Cr+ attachment to be the carbonyl oxygen site for acetophenone (bis-complex) and the ring-pi site for anisole and aniline (both mono- and bis-complexes). The bis-complexes of aniline and anisole are low-spin (probably doublet) states, while the mono-complexes of these same ligands are high-spin (sextet) states. The dimethyl aniline complex gave a cluttered spectrum in poor agreement with calculations, which may reflect a mixture of binding-site isomers in this case. 相似文献
92.
Fingering instabilities in films moving along wetted surfaces, dimpling in horizontal liquid films, and the drainage of vertical soap films by marginal regeneration are caused by surface tension gradients along the perimeter of the thin film. These gradients lead to a mechanical instability which involves Marangoni type liquid flow. It is possible to describe the conditions for the onset of marginal regeneration with a critical number of the ratio between the driving force for the Marangoni flow and the friction of film elements that move relative to their surroundings. This ratio is called the Mysels number. A linear stability analysis leads to a scaling relation lambda approximately h(Ca)(-1/3) between the wavelength lambda of the instability and the capillary number Ca (Ca=/etaV(s)/gamma. In experiments with several Marangoni-driven instabilities this scaling relation has been found; it illustrates the general applicability in the understanding of flow phenomena of this type. Copyright 2001 Academic Press. 相似文献
93.
The gas-phase infrared absorption spectra of neutral benzyl and tropyl, isomers of formula C7H7, have been measured in the 400-1800 cm-1 spectral region. In addition, a quantum chemical calculation has been performed to model the infrared spectra. For the benzyl radical, the theory shows satisfactory overlap with the experiment, although vibrations involving the CH2 group might be anharmonic. The tropyl radical, which is subject to the Jahn-Teller effect, seems well modeled for the out-of-plane vibrational modes, but less so for the in-plane vibrational modes. 相似文献
94.
József Medve Jerry Ståhlberg Folke Tjerneld 《Applied biochemistry and biotechnology》1997,66(1):39-56
Adsorption to microcrystalline cellulose (Avicel) of pure cellobiohydrolase I and II (CBH I and CBH II) fromTrichoderma reesei has been studied. Adsorption isotherms of the enzymes were measured at 4‡C using CBH I and CBH II alone and in reconstituted
equimolar mixtures. Several models (Langmuir, Freundlich, Temkin, Jovanovic) were tested to describe the experimental adsorption
isotherms. The isotherms did not follow the basic (one site) Langmuir equation that has often been used to describe adsorption
isotherms of cellulases; correlation coefficients (R2) were only 0.926 and 0.947, for CBH I and II, respectively. The experimental isotherms were best described by a model of
Langmuir type with two adsorption sites and by a combined Langmuir-Freundlich model (analogous to the Hill equation); using
these models the correlation coefficients were in most cases higher than 0.995. Apparent binding parameters derived from the
two sites Langmuir model indicated stronger binding of CBH II compared to CBH I; the distribution coefficients were 20.7 and
3.7 L/g for the two enzymes, respectively. The binding capacity, on the other hand, was higher for CBH I, 1.0 Μmol (67 mg)
per gram Avicel, compared to 0.57 Μmol/g (30 mg/g) for CBH II. The isotherms when analyzed with the combined Langmuir-Freundlich
model indicated presence of unequal binding sites on cellulose and/or negative cooperativity in the binding of the enzyme
molecules. 相似文献
95.
A very selective method is described for the determination of doxorubicin in rat plasma. Doxorubicin is extracted from the plasma on a pretreated octadecyl silane column and eluted with phosphate buffer pH 2.6/methanol (25/75, v/v) containing sodium 1-heptanesulfonate as ion-pairing agent. The extraction procedure is suitable for samples which contain doxorubicin encapsulated in liposomes if Triton X-100 is added. A portion of the evaporated eluate is used for high-performance reversed-phase chromatography with the same eluent and a fluorescence detector. Daunorubicin is used as internal standard. Extraction of doxorubicin from plasma is quantitative. The calibration graph is linear for 0.2-100 μg l?1 doxorubicin with a limit of detection of 0.2 μg l?1 for 0.5 ml of plasma. The relative standard error of estimate of the calibration was typically 3%. 相似文献
96.
The determination of residual amounts of bromide in a local anaesthetic hydrochloride by capillary electrophoresis was developed. Direct UV detection at 200 nm was used for the determination of the bromide content. The separation capacity of the system must be sufficient when bromide is determined in the presence of a large excess of chloride since electromigration dispersion of the highly concentrated chloride peak may impair the resolution. The background electrolyte (BGE) contained both acetonitrile and methanesulphonic acid in order to improve the selectivity and minimise the electromigration dispersion. The system was optimised with respect to resolution of the chloride and the bromide peaks by statistical experimental design using a multivariate optimisation program. The developed method was validated in accordance with the ICH guidelines and proved to be suitable for its intended use. 相似文献
97.
Johansson A Abrahamsson M Magnuson A Huang P Mårtensson J Styring S Hammarström L Sun L Akermark B 《Inorganic chemistry》2003,42(23):7502-7511
The preparation of donor (D)-photosensitizer (S) arrays, consisting of a manganese complex as D and a ruthenium tris(bipyridyl) complex as S has been pursued. Two new ruthenium complexes containing coordinating sites for one (2a) and two manganese ions (3a) were prepared in order to provide models for the donor side of photosystem II in green plants. The manganese coordinating site consists of bridging and terminal phenolate as well as terminal pyridyl ligands. The corresponding ruthenium-manganese complexes, a manganese monomer 2b and dimer 3b, were obtained. For the dimer 3b, our data suggest that intramolecular electron transfer from manganese to photogenerated ruthenium(III) is fast, k(ET) > 5 x 10(7) s(-)(1). 相似文献
98.
The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T, which is shown to be approximated by a chi(2) distribution. Application of this test to the results of determinations of manganese in human serum by a method of established precision, led to the detection of airborne pollution of the serum during the sampling process. The subsequent improvement in sampling conditions was shown to give not only increased precision, but also improved accuracy of the results. 相似文献
99.
Buijs J Håkansson K Hagman C Håkansson P Oscarsson S 《Rapid communications in mass spectrometry : RCM》2000,14(19):1751-1756
A new method is presented to accurately determine the probability of having a deuterium or hydrogen atom on a specific amide position within a peptide after deuterium/hydrogen (D/H) exchange in solution. Amide hydrogen exchange has been proven to be a sensitive probe for studying protein structures and structural dynamics. At the same time, mass spectrometry in combination with physical fragmentation methods is commonly used to sequence proteins based on an amino acid residue specific mass analysis. In the present study it is demonstrated that the isotopic patterns of a series of peptide fragment ions obtained with capillary-skimmer dissociation, as observed with a 9.4 T Fourier transform ion cyclotron resonance (FTICR) mass spectrometer, can be used to calculate the isotopic state of specific amide hydrogens. This calculation is based on the experimentally observed isotopic patterns of two consecutive fragments and on the isotopic binomial distributions of the atoms in the residue constituting the difference between these two consecutive fragments. The applicability of the method is demonstrated by following the sequence-specific D/H exchange rate in solution of single amide hydrogens within some peptides. 相似文献
100.
Application of the JKR Method to the Measurement of Adhesion to Langmuir-Blodgett Cellulose Surfaces
Rundlöf M Karlsson M Wågberg L Poptoshev E Rutland M Claesson P 《Journal of colloid and interface science》2000,230(2):441-447
The JKR method has been applied for studying adhesion between poly(dimethylsiloxane) (PDMS) caps and Langmuir–Blodgett cellulose surfaces including the substrate, hydrophobized mica, and two flat mineral surfaces, bare mica and glass. The self-adhesion of PDMS caps and oxidized PDMS caps are included as a reference to compare with literature data. The results of the measurements have been compared with previous studies using the surface force apparatus and similar systems. A satisfactory agreement is obtained for simple systems showing no, or very limited, hysteresis between loading and unloading curves. In several cases, however, a large hysteresis is found between loading and unloading curves, with a larger adhesion measured from the pull-off force than from the JKR-curve determined on loading. This is, for instance, the case for PDMS against cellulose. The situation is analogous to that found in wetting studies showing a large hysteresis between advancing and receding contact angles. 相似文献